Fluorescence induced with 5-aminolevulinic acid for the endoscopic detection and follow-up of esophageal lesions

Mayinger, Brigitte; Neidhardt, Sabine; H, Reh; Martus, Peter; Hahn, Eckhart G.

doi:10.1067/mge.2001.118642

Cited by 59 publications

(17 citation statements)

References 30 publications

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“…Potential contributing factors include recent biopsy and resulting re-epithelialization, which has been shown to contribute to false positives in another study evaluating a different fluorescent contrast agent. 48 While it is important to understand how such factors influence the VFI technique, a larger study is required to make such an assessment. Moreover, additional studies are needed to understand whether high-resolution microscopy or another secondary imaging technique would aid in reducing the number of false positives.…”

Section: Discussionmentioning

confidence: 99%

“…Ingestible agents such as 5-aminolevulinic acid have been shown to identify neoplastic lesions in vivo; 20,21 however, current research prioritizes its use with photodynamic therapy. 22,23 A variety of biomarkers have been identified to assess the presence of disease ex vivo through histologic staining; the cytosponge technique has been shown to aid in identifying those biomarkers postprocedure.…”

Section: Introductionmentioning

confidence: 99%

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Quantitative evaluation ofin vivovital-dye fluorescence endoscopic imaging for the detection of Barrett’s-associated neoplasia

et al. 2015

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Abstract. Current imaging tools are associated with inconsistent sensitivity and specificity for detection of Barrett's-associated neoplasia. Optical imaging has shown promise in improving the classification of neoplasia in vivo. The goal of this pilot study was to evaluate whether in vivo vital dye fluorescence imaging (VFI) has the potential to improve the accuracy of early-detection of Barrett's-associated neoplasia. In vivo endoscopic VFI images were collected from 65 sites in 14 patients with confirmed Barrett's esophagus (BE), dysplasia, or esophageal adenocarcinoma using a modular video endoscope and a high-resolution microendoscope (HRME). Qualitative image features were compared to histology; VFI and HRME images show changes in glandular structure associated with neoplastic progression. Quantitative image features in VFI images were identified for objective image classification of metaplasia and neoplasia, and a diagnostic algorithm was developed using leave-one-out cross validation. Three image features extracted from VFI images were used to classify tissue as neoplastic or not with a sensitivity of 87.8% and a specificity of 77.6% (AUC ¼ 0.878). A multimodal approach incorporating VFI and HRME imaging can delineate epithelial changes present in Barrett's-associated neoplasia. Quantitative analysis of VFI images may provide a means for objective interpretation of BE during surveillance. © The Authors. Published by SPIE under a Creative Commons Attribution 3.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Quantitative evaluation ofin vivovital-dye fluorescence endoscopic imaging for the detection of Barrett’s-associated neoplasia

et al. 2015

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“…Although CT imaging is the single most widely used procedure for cancer staging, several other techniques can enhance the accuracy of staging in esophageal malignancies (Table 2) [4]. These techniques include endoscopic ultrasound (EUS) [5,6,7••,8,9••], positron emission tomography (PET) [1,10,11], optical coherence tomography (OCT) [12•], chromoscopy [13•], high-resolution/magnification endoscopy [14], endoscopic magnetic resonance imaging (MRI) [15], fluorescent endoscopy [16][17][18], and ultrasonic tactile sensing [19]. Some of the techniques for staging can also be used for screening in high-risk populations for esophageal cancer.…”

Section: Endoscopic Diagnosis and Staging Of Esophageal Malignanciesmentioning

confidence: 99%

Nonsurgical approaches to esophageal malignancy

Sorbi

Fleischer

2003

Curr Gastroenterol Rep

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Esophageal cancer remains one of the leading causes of cancer death worldwide. Patients generally present with progressive dysphagia, malnutrition, and weight loss. The diagnosis commonly involves radiologic studies and conventional esophagogastroduodenoscopy. Advances in endoscopic evaluation have allowed early detection of premalignant and malignant lesions. These techniques include chromoscopy, which can be performed in conjunction with high-resolution/magnification endoscopy, and fluorescent endoscopy. Such techniques as endoscopic ultrasound with dedicated echoendoscopes or high-frequency probes, positron emission tomography, optical coherence tomography, endoscopic magnetic resonance imaging, and tactile sensing may complement conventional imaging by CT to enhance staging accuracy. Because the majority of patients present with incurable disease at the time of diagnosis, nonsurgical approaches to their management have evolved. These include endoscopic mucosal resection, stenting, tumor ablation, and palliative chemoradiotherapy. The ablative techniques include argon plasma coagulator therapy, laser, and photodynamic therapy. For patients with early malignancies of the esophagus who are not surgical candidates, such techniques may be used with curative intent.

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“…Ainsi, Mayinger et al ont rapporté une excellente sensibilité (98 %) et spécificité (89 %) de la spectroscopie de dispersion élastique pour différencier les lésions adénomateuses et non adénomateuses colorectales [21]. Comme pour l'imagerie endoscopique par fluorescence, l'intensité et la spécificité de la fluorescence peuvent être améliorées par l'administration de fluorophores exogènes.…”

Section: Spectroscopie De Dispersion éLastiqueunclassified

Nouvelles techniques de visualisation de la muqueuse digestive

Coron

2007

Côlon Rectum

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Les points essentiels -Récemment, plusieurs modalités d'imagerie endoscopique ont été développées dans le but de permettre une analyse de plus en plus détaillée de la muqueuse digestive. Dès lors, un enjeu majeur de la coloscopie est la détection des lésions néoplasiques à un stade très précoce et si possible leur résection dans un même temps ;-certaines de ces modalités font d'ores et déjà partie de notre arsenal endoscopique comme la haute résolution, les zooms et l'endoscopie à bandes spectrales étroites (systèmes NBI et FICE). Elles sont utiles en pratique clinique pour aider à mieux caractériser des lésions décelables en endoscopie « conventionnelle » (type macroscopique et examen des berges) ; -d'autres techniques d'imagerie plus pointues, en voie de développement ou très récemment commercialisées, visent à l'obtention d'une véritable « biopsie optique ». Il s'agit de l'endocytoscopie, l'endomicroscopie confocale (fibrée ou non), la spectroscopie de dispersion élastique, la tomographie par cohérence optique, et les techniques de fluorescence spontanée (autofluorescence) et induite ; -la plupart de ces dernières techniques sont utilisées uniquement en recherche endoscopique à l'heure actuelle, mais pourraient trouver une place importante dans l'endoscopie diagnostique dans un futur proche, notamment dans la prise en charge des lésions néoplasiques précoces : amélioration du dépis-tage de lésions cancéreuses précoces, obtention d'un diagnostic de nature en temps réel afin de guider le geste endoscopique ; -à côté de ces progrès optiques, les progrès mécaniques ont permis le développement d'autres modalités de visualisation de la muqueuse telles que la vidéocapsule colique ou l'Aer-O-Scope TM . Ces nouveaux endoscopes visent à proposer une alternative « mini-invasive » à la coloscopie standard. Ces techniques sont en cours d'évaluation. Les références essentiellesKiesslich R, Fritsch J, Holtmann M et al. (2003) Methylene blue-aided chromoendoscopy for the detection of intraepithelial neoplasia and colon cancer in ulcerative colitis. Gastroenterology 124: 880-8 Chiu HM, Chang CY, Chen CC et al. (2007) A prospective comparative study of narrow-band imaging, chromoendoscopy, and conventional colonoscopy in the diagnosis of colorectal neoplasia. Gut 56: 373-9 Dekker E, van den Broek FJ, Reitsma JB et al. (2007) Narrow-band imaging compared with conventional colonoscopy for the detection of dysplasia in patients with longstanding ulcerative colitis. Endoscopy 39: 216-21 Kiesslich R, Goetz M, Lammersdorf K et al. (2007) Chromoscopy-guided endomicroscopy increases the diagnostic yield of intraepithelial neoplasia in ulcerative colitis. Gastroenterology 132: 874-82 Roy HK, Kim YL, Liu Y et al. (2006) Risk stratification of colon carcinogenesis through enhanced backscattering spectroscopy analysis of the uninvolved colonic mucosa. Clin Cancer Res 12: 961-8Ce que dit l'EBM -Il existe peu d'études évaluant les nouvelles techniques de visualisation de la muqueuse. Il s'agit principalement d'études pilotes, plus rarement d...

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Fluorescence induced with 5-aminolevulinic acid for the endoscopic detection and follow-up of esophageal lesions

Cited by 59 publications

References 30 publications

Quantitative evaluation ofin vivovital-dye fluorescence endoscopic imaging for the detection of Barrett’s-associated neoplasia

Quantitative evaluation ofin vivovital-dye fluorescence endoscopic imaging for the detection of Barrett’s-associated neoplasia

Nonsurgical approaches to esophageal malignancy

Nouvelles techniques de visualisation de la muqueuse digestive

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