Fluorescence Lifetime Spectroscopy in Cardioand Neuroimaging

Marcu, Laura; Jo, Javier A.; Butte, Pramod

doi:10.1002/9780470767061.ch9

Cited by 3 publications

(3 citation statements)

References 93 publications

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“…Numerous time-resolved fluorescence studies were conducted in excised tissue specimens, 2,5,6,16,17,23 however the outcome of these studies cannot be fully extrapolated to in vivo measurements. 23,86,94 This is due to changes in tissue biochemical composition related to functional properties (e.g. metabolism, hypoxia, etc) as well as changes in tissue morphology generated by shrinkage or other factors that affects tissue geometry post-excision.…”

Section: Fluorescence In Tissue Characterization and Diagnosismentioning

confidence: 99%

Fluorescence Lifetime Techniques in Medical Applications

2012

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This article presents an overview of time-resolved (lifetime) fluorescence techniques used in biomedical diagnostics. In particular, we review the development of time-resolved fluorescence spectroscopy (TRFS) and fluorescence lifetime imaging (FLIM) instrumentation and associated methodologies which allows for in vivo characterization and diagnosis of biological tissues. Emphasis is placed on the translational research potential of these techniques and on evaluating whether intrinsic fluorescence signals provide useful contrast for the diagnosis of human diseases including cancer (gastrointestinal tract, lung, head and neck, and brain), skin and eye diseases, and atherosclerotic cardiovascular disease.

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Section: Fluorescence In Tissue Characterization and Diagnosismentioning

confidence: 99%

Fluorescence Lifetime Techniques in Medical Applications

2012

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“…Fluorescence lifetime, on the other hand, is independent of all these experimental conditions . Fig.…”

Section: Resultsmentioning

confidence: 84%

“…Fluorescence lifetime, on the other hand, is independent of all these experimental conditions. [23][24][25] Fig. 2c illustrates the lifetime spectra from normal and OLP tissues, as derived from the time-resolved fluorescence measurements.…”

Section: Resultsmentioning

confidence: 99%