Fluorescence microscopic and histologic analysis of photosensitizer uptake in human atherosclerotic lesions

Gonschior, P.; Erdemci, A.; Gerheuser, Florian; Mack, Brigitte; Gonschior, G. M.; Groh, J; Leunig, Michael; Goetz, Alwin E.; Höfling, B.

doi:10.1007/bf02547853

Cited by 2 publications

(1 citation statement)

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“…It accumulates in cells and its uptake increased in hypercellular or low-density lipoprotein receptor-rich areas (2.19). When incubated a transmural gradient of Photofrin exists within atherosclerotic intimal plaque, with higher concentrations near the lumen (20).…”

Section: Discussionmentioning

confidence: 99%

Local Photodynamic Therapy Reduces Tissue Hyperplasia in an Experimental Restenosis Model

Gonschior¹,

Gerheuser²,

Fleuchaus³

et al. 1996

Photochem & Photobiology

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Local photodynamic therapy may have potential in preventing myointimal hyperplasia after angioplasty. In this study, the effect of photodynamic therapy was evaluated in an experimental model of restenosis. Standardized unidirectional arterial injury with a directional atherectomy catheter was performed in porcine arteries. Animals were randomly allocated to four groups: group 1, unidirectional injury only; group 2, injury followed by local delivery of photosensitizer; group 3, injury followed by local exposure to monochromatic light; and group 4, where injury was followed by local drug delivery of photosensitizer and subsequent exposure to light (photodynamic therapy). Seven, 14 or 21 days after treatment, all experimental vessels were excised, fixed and processed for histology. An inflammatory and myoproliferative response was observed after injury in vessels from groups 1, 2 and 3. In group 4, after injury followed by photodynamic therapy, the myoproliferative response was significantly reduced. Thus, in this study, tissue hyperplasia after unidirectional injury was effectively suppressed by photodynamic therapy.

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Section: Discussionmentioning

confidence: 99%