Fluorescence of human lymphatic and cancer tissues following high doses of intravenous hematoporphyrin

Rassmussen-Taxdal, D. S.; Ward, Grant E.; Figge, Frank

doi:10.1002/1097-0142(1955)8:1<78::aid-cncr2820080109>3.0.co;2-l

Cited by 180 publications

(43 citation statements)

References 2 publications

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“…The field of optical imaging emerged in the early 20th century with the observation of porphyrin fluorescence in certain tumors, but a lack of fundamental knowledge and suitable optical equipment prevented further development at the time (4). The finding that photons in the NIR range (650-900 nm) travel through tissue much deeper than photons in the visible light range (5) was essential for the advancement of optical imaging toward clinical practice, and further development gained momentum over the past decade (1,6).…”

Section: Introductionmentioning

confidence: 99%

Optical Image-Guided Cancer Surgery: Challenges and Limitations

Keereweer

Driel

Snoeks

et al. 2013

Clinical Cancer Research

229

209

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Optical image-guided cancer surgery is a promising technique to adequately determine tumor margins by tumor-specific targeting, potentially resulting in complete resection of tumor tissue with improved survival. However, identification of the photons coming from the fluorescent contrast agent is complicated by autofluorescence, optical tissue properties, and accurate fluorescent targeting agents and imaging systems. All these factors have an important influence on the image that is presented to the surgeon. Considering the clinical consequences at stake, it is a prerequisite to answer the questions that are essential for the surgeon. What is optical image-guided surgery and how can it improve patient care? What should the oncologic surgeon know about the fundamental principles of optical imaging to understand which conclusions can be drawn from the images? And how do the limitations influence clinical decision making? This article discusses these questions and provides a clear overview of the basic principles and practical applications. Although there are limitations to the intrinsic capacity of the technique, when practical and technical surgical possibilities are considered, optical imaging can be a very powerful intraoperative tool in guiding the future oncologic surgeon toward radical resection and optimal clinical results.

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Section: Introductionmentioning

confidence: 99%

Optical Image-Guided Cancer Surgery: Challenges and Limitations

Keereweer

Driel

Snoeks

et al. 2013

Clinical Cancer Research

229

209

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“…Although several porphyrins have been shown, by fluorescence as well as by radiolabeling and chemical assay, to accumulate in nonneoplastic tissues (13)(14)(15)(16), the affinity of other diseased tissues for HPD has received little attention. However, it has been suggested that rapidly proliferating tissues, in general, may preferentially concentrate HPD (17).…”

Section: Introductionmentioning

confidence: 99%

Fluorescence of experimental atheromatous plaques with hematoporphyrin derivative.

Spears¹,

Serur²,

Shropshire³

et al. 1983

J. Clin. Invest.

148

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“…It was observed that the fluorescence in tumors increased proportionally with the applied dose of porphyrin. The authors even managed to locate a breast carcinoma through intact skin and an adenocarcinoma through the abdominal wall [12]. Currently, the main use of fluorescence diagnosis in practice is the exact detection and localization of poorly demarcated neoplasms.…”

Section: History Of Fluorescence Detectionmentioning

confidence: 99%

New developments in fluorescence diagnostics

Hegyi

Ruzicka

et al. 2011

J Deutsche Derma Gesell

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SummaryIn the last decade, significant advances have been achieved in the direct viewing of the skin. Non-invasive analysis of various skin diseases in vivo has become possible by special skin display devices, allowing the physician to view the structure and properties of the skin in greater detail than can be achieved by simple visual examination. We review the last 100 years of fluorescence imaging development from clinical observation to advanced spectral imaging, addressing the role of fluorescence diagnostics (FD) in modern dermatology as well as the detection of autofluorescence.

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Fluorescence of human lymphatic and cancer tissues following high doses of intravenous hematoporphyrin

Cited by 180 publications

References 2 publications

Optical Image-Guided Cancer Surgery: Challenges and Limitations

Optical Image-Guided Cancer Surgery: Challenges and Limitations

Fluorescence of experimental atheromatous plaques with hematoporphyrin derivative.

New developments in fluorescence diagnostics

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