Fluorescence of Photo-degraded Tyrosine Solutions

Weyl, D.A.; Murfin, D.

doi:10.1038/212921a0

Cited by 6 publications

(1 citation statement)

References 4 publications

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“…Moreover, Phe residues are not excited due to low quantum yield. In contrast, Tyr residues have the strongest fluorescence intensity at the maximum emission wavelength of 303 nm and are most sensitive to microenvironment changes, which indicate conformational changes upon compound binding [41]. In our experimental conditions, Tau quenching was monitored between 280 and 500 nm, with an excitation at 275 nm.…”

Section: Kinetics and Mechanism Of Thiazoloflavonoids Binding To Tau ...mentioning

confidence: 99%

2-Aminothiazole-Flavonoid Hybrid Derivatives Binding to Tau Protein and Responsible for Antitumor Activity in Glioblastoma

Hedna,

DiMaio,

Robin

et al. 2023

IJMS

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Tau protein has been described for several decades as a promoter of tubulin assembly into microtubules. Dysregulation or alterations in Tau expression have been related to various brain cancers, including the highly aggressive and lethal brain tumor glioblastoma multiform (GBM). In this respect, Tau holds significant promise as a target for the development of novel therapies. Here, we examined the structure–activity relationship of a new series of seventeen 2-aminothiazole-fused to flavonoid hybrid compounds (TZF) on Tau binding, Tau fibrillation, and cellular effects on Tau-expressing cancer cells. By spectrofluorometric approach, we found that two compounds, 2 and 9, demonstrated high affinity for Tau and exhibited a strong propensity to inhibit Tau fibrillation. Then, the biological activity of these compounds was evaluated on several Tau-expressing cells derived from glioblastoma. The two lead compounds displayed a high anti-metabolic activity on cells related to an increased fission of the mitochondria network. Moreover, we showed that both compounds induced microtubule bundling within newly formed neurite-like protrusions, as well as with defection of cell migration. Taken together, our results provide a strong experimental basis to develop new potent molecules targeting Tau-expressing cancer cells, such as GBM.

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Section: Kinetics and Mechanism Of Thiazoloflavonoids Binding To Tau ...mentioning

confidence: 99%

2-Aminothiazole-Flavonoid Hybrid Derivatives Binding to Tau Protein and Responsible for Antitumor Activity in Glioblastoma

Hedna,

DiMaio,

Robin

et al. 2023

IJMS

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Melt‐processed polymer multilayer distributed feedback lasers: Progress and prospects

Andrews

Crescimanno

Singer

et al. 2013

J Polym Sci B Polym Phys

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Reflecting recent progress in the functionalization of roll-to-roll processed polymer multilayers, this review describes the development and characterization of versatile large-area multilayer distributed feedback (DFB) lasers. These developments are reviewed in the broader context of microresonator lasers, with a brief tutorial on the theory and experiment needed to understand their unique features. Of particular interest is the broad tunability of these DFB lasers by simple modification of their structure, mechanical stretching, and temperature. Prospects for commercialization of polymer multilayer DFB lasers are also discussed.

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One-pot green preparation of deep-ultraviolet and dual-emission carbon nanodots for dual-channel ratiometric determination of polyphenol in tea sample

Wang

et al. 2022

Microchim Acta

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Fluorescence of Photo-degraded Tyrosine Solutions

Cited by 6 publications

References 4 publications

2-Aminothiazole-Flavonoid Hybrid Derivatives Binding to Tau Protein and Responsible for Antitumor Activity in Glioblastoma

2-Aminothiazole-Flavonoid Hybrid Derivatives Binding to Tau Protein and Responsible for Antitumor Activity in Glioblastoma

Melt‐processed polymer multilayer distributed feedback lasers: Progress and prospects

One-pot green preparation of deep-ultraviolet and dual-emission carbon nanodots for dual-channel ratiometric determination of polyphenol in tea sample

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