Fluorescence, reflectance, and light-scattering spectroscopy for evaluating dysplasia in patients with Barrett's esophagus

Georgakoudi, Irene; Jacobson, Brian C.; Dam, Jacques Van; Backman, Vadim; Wallace, Michael B.; Müller, Markus; Zhang, Qingguo; Badizadegan, Kamran; Sun, Donglei; Thomas, G. A.; Perelman, Lev T.; Feld, Michael S.

doi:10.1053/gast.2001.24842

Cited by 418 publications

(303 citation statements)

References 43 publications

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“…Spectroscopic devices can analyze the light coming from the mucosa and assess its components to determine the degree of dysplasia that is present. Newer instruments that can assess optical properties such as reflectance, fluorescence, and light scattering have been combined to allow improved characterization of the mucosa (72). At the present time, commercial availability of these instruments is limited to laser confocal microscopy in an endoscope and probe systems.…”

Section: Imaging In Barrett's Esophagusmentioning

confidence: 99%

Updated Guidelines 2008 for the Diagnosis, Surveillance and Therapy of Barrett's Esophagus

Sampliner

2008

The American Journal of Gastroenterology

1,280

893

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PREAMBLEThe guidelines for the diagnosis, surveillance and therapy of Barrett's esophagus were originally published by the American College of Gastroenterology in 1998 and updated in 2002. These and other guidelines undergo periodic review. Significant advances have occurred in the area of Barrett's esophagus over the past four years leading to another revision of the prior guidelines. These advances include the potential use of esophageal capsule endoscopy for the diagnosis and screening of Barrett's esophagus, data regarding the outcome of low-grade dysplasia, the treatment of high-grade dysplasia using photodynamic therapy, and the development of new ablation techniques such as radiofrequency ablation. These guidelines are intended to be applied by physicians who see Barrett's esophagus patients and are intended to indicate a preferred, but certainly not the only, acceptable approach. Physicians need to choose the course best suited to the individual patient and to the variables that exist at the time of decision making. The guidelines are for adult patients with the diagnosis of Barrett's esophagus, as defined herein.Both these and the original guidelines were developed under auspices of the American College of Gastroenterology and the Practice Parameters Committee and approved by the Board of Trustees. The world literature was reviewed extensively for the original guidelines and once again reviewed using the National Library of Medicine database. Search terms used included Barrett's esophagus, esophageal neoplasm, esophagus, intestinal metaplasia, esophageal diseases, and adenocarcinoma, all appropriate studies and any additional ones found in reference to these papers were obtained and reviewed. Evidence was available from a hierarchy of trials and randomized controlled trials were given the greatest weight. Abstracts presented at national and international meetings were only used when unique data from ongoing trials were presented. When scientific data were lacking, recommendations are based on expert opinion. The recommendations made are based on the level of evidence found. Grade A recommendations imply that there is consistent level 1 evidence (randomized controlled trials), Grade B indicates that the evidence would be level 2 or 3 which are cohort studies or case control studies. Grade C recommendations are based on level 4 studies meaning case series or poor quality cohort studies, and Grade D recommendations are based on level 5 evidence meaning expert opinion.

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Section: Imaging In Barrett's Esophagusmentioning

confidence: 99%

Updated Guidelines 2008 for the Diagnosis, Surveillance and Therapy of Barrett's Esophagus

Sampliner

2008

The American Journal of Gastroenterology

1,280

893

View full text Add to dashboard Cite

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“…Three common spectroscopic techniques are Raman spectroscopy (RS), diffuse reflectance spectroscopy (DRS), and laser-induced fluorescence spectroscopy (LIFS). These techniques have been applied -either individually or in combinations -throughout the entire human body to investigate a wide range of pathologies including: atherosclerosis, 1, 2 osteoporosis, 3 brain edema, 4 cataract formation, 5 kidney stones, 6,7 and diabetes 8 and cancer of the breast, 9-11 cervix, 12 esophagus, 13,14 gastrointestinal tract, 15,16 brain, 17 lungs, 18,19 ovaries, 20 and bladder. 21 Here, we present a novel multimodal spectroscopy (MMS) device, combining RS, LIFS, and DRS, for the purpose of fast and non-invasive early detection of skin cancer which uses a variety of instrumentation and a custom contact probe capable of delivering and collecting light for all three modalities.…”

Section: Introductionmentioning

confidence: 99%

Design and characterization of a novel multimodal fiber-optic probe and spectroscopy system for skin cancer applications

Sharma

Marple²,

Reichenberg

et al. 2014

Review of Scientific Instruments

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The design and characterization of an instrument combining Raman, fluorescence, and reflectance spectroscopic modalities is presented. Instrument development has targeted skin cancer applications as a novel fiber-optic probe has been specially designed to interrogate cutaneous lesions. The instrument is modular and both its software and hardware components are described in depth. Characterization of the fiber-optic probe is also presented, which details the probe's ability to measure diagnostically important parameters such as intrinsic fluorescence and absorption and reduced scattering coefficients along with critical performance metrics such as high Raman signal-to-noise ratios at clinically practical exposure times. Validation results using liquid phantoms show that the probe and system can extract absorption and scattering coefficients with less than 10% error. As the goal is to use the instrument for the clinical early detection of skin cancer, preliminary clinical data are also presented, which indicates our system's ability to measure physiological quantities such as relative collagen and nicotinamide adenine dinucleotide concentration, oxygen saturation, blood volume fraction, and mean vessel diameter.

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“…Such distortions could be mathematically simulated and extracted -to reveal intrinsic autofluorescence of the tissue, unaffected by absorption and scattering events. For better processing of the autofluorescence spectra received, researchers measured reflectance spectra from the same tissue area and extract signal, related to hemoglobin re-absorption of the native fluorescence of the tissue (Georgakoudi, 2001;Filip, 2011). In the case of autofluorescence detection high sensitivity and specificity could be achieved if complex algorithms are applied for differentiation of the spectra (Ell, 2003).…”

Section: Light-induced Autofluorescence Detection Of Gastrointestinalmentioning

confidence: 99%

“…The new optical approaches are based on light-tissue interactions and differences occurred between normal and abnormal tissue sites. In gastroenterology several optical methods are applied recently, such as optical coherent tomography (Tumlinson, 2004), chromo-endoscopy, confocal fluorescent microscopy (DaCosta, 2003a;2003b), Raman spectroscopy (Yan, 2005), reflectance spectroscopy (Sun, 2001) and laser-and lightinduced fluorescence spectroscopy (Chissov, 2003). In general, photodiagnostic techniques may be very useful for the detection of pre-maliganant dysplasia and early malignant changes in gastrointestinal tract.…”

Section: Introductionmentioning

confidence: 99%

Light-Induced Fluorescence Techniques for Gastrointestinal Tumour Detection

Borisova¹,

Vladimirov²,

Ivanova³

et al. 2011

New Techniques in Gastrointestinal Endoscopy

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Fluorescence, reflectance, and light-scattering spectroscopy for evaluating dysplasia in patients with Barrett's esophagus

Cited by 418 publications

References 43 publications

Updated Guidelines 2008 for the Diagnosis, Surveillance and Therapy of Barrett's Esophagus

Updated Guidelines 2008 for the Diagnosis, Surveillance and Therapy of Barrett's Esophagus

Design and characterization of a novel multimodal fiber-optic probe and spectroscopy system for skin cancer applications

Light-Induced Fluorescence Techniques for Gastrointestinal Tumour Detection

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