Fluorescence Spectra of Blood Components for Breast Cancer Diagnosis

Kalaivani, R.; Masilamani, V.; Sivaji, K.; Elangovan, M.; Selvaraj, Vinodh Kumar; Balamurugan, Subramani; Al-Salhi, M.S.

doi:10.1089/pho.2007.2162

Cited by 64 publications

(50 citation statements)

References 22 publications

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“…It indicates that porphyrins accumulate more in tumor parts. The knowledge about the mechanisms of precursor 5-ALA lead to PpIX accumulation was demonstrated in many tumor diseases [48][49][50]. Our results showed that for the majority of the patients (80.0%), I 630 nm /I 590 nm of each individual patient's tumor sample was higher than that of normal sample.…”

Section: Discussionmentioning

confidence: 63%

Autofluorescence Imaging and Spectroscopy of Human Lung Cancer

et al. 2016

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Lung cancer is one of the most common cancers, with high mortality rate worldwide. Autofluorescence imaging and spectroscopy is a non-invasive, label-free, real-time technique for cancer detection. In this study, lung tissue sections excised from patients were detected by laser scan confocal microscopy and spectroscopy. The autofluorescence images demonstrated the cellular morphology and tissue structure, as well as the pathology of stained images. Based on the spectra study, it was found that the majority of the patients showed discriminating fluorescence in tumor tissues from normal tissues. Therefore, autofluorescence imaging and spectroscopy may be a potential method for aiding the diagnosis of lung cancer.

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Section: Discussionmentioning

confidence: 63%

Autofluorescence Imaging and Spectroscopy of Human Lung Cancer

et al. 2016

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“…As the steady-state fluorescence spectra for blood samples of cancer patients have been studied extensively, [8][9][10][11][12] the discussion will focus only on one pertinent observation. In the field of fluorescence spectroscopy, the relative intensities of different peaks are more important than the actual, absolute intensities.…”

Section: Discussionmentioning

confidence: 99%

“…We reported in our previous papers [8][9][10] on the results of steady-state measurements of blood components for cancer diagnosis using porphyrin as a biomarker. The results showed a significant discrimination accuracy to classify the diseased blood from normal blood.…”

Section: -6mentioning

confidence: 99%

Cervical cancer detection by time-resolved spectra of blood components

et al. 2014

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Abstract. Fluorescence spectral techniques are very sensitive, and hence they are gaining importance in cancer detection. The biomarkers indicative of cancer could be identified and quantified by spectral or time domain fluorescence spectroscopy. The results of an investigation of time-resolved spectra of cellular components of blood obtained from cervical cancer patients and normal controls are given. The cancer indicative biomarker in this paper is porphyrin; it has a fluorescence decay time of 60% more in samples of cancer patients than those of normal controls. Based on such measurements, a randomized set comprising samples from cancer patients and controls (N ¼ 27 in total) could be classified with sensitivity (92%) and specificity (86%).

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“…The instrumentation and techniques employed in this study are similar to those previously described in the literature [8][9][10][11] . In order to highlight the major differences in spectral features of blood components in pregnant women, blood plasma and RBC samples were obtained from normal control and patients with thalassaemia.…”

mentioning

confidence: 99%

“…Further, haematoporphyrin is a mixture of many derivatives with protoporphyrin IX as the principal fluorescing component. The 585 nm band is attributed to the basic and 632 nm to the neutral form of haematoporphyrin [10][11][12] . The intensity of the band at 632 nm was twofold higher for the pregnant women, but only 50% for Thal patients when compared to the normal control group.…”

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confidence: 99%

Fluorescence Spectral Features of Blood Components of Pregnant Women

Devanesan¹,

Alshebly²,

Kalaivani³

et al. 2017

Current Science

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End-to-end research evaluation needs to separate out the bibliometric part of the chain from the econometric part. Both size-dependent and size-independent terms play a crucial role to combine quantity and quality (impact) in a meaningful way. Output or outcome at the bibliometric level can be measured using zeroth, first or secondorder composite indicators, and the productivity terms follow accordingly using the input to output or outcome factors.

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Fluorescence Spectra of Blood Components for Breast Cancer Diagnosis

Abstract: Our statistical evaluation indicates that porphyrin in blood can be used as a reliable tumor marker. Fluorescence emission spectroscopy of blood components and statistical evaluations should be further investigated for a variety of tumors.

Cited by 64 publications

References 22 publications

Autofluorescence Imaging and Spectroscopy of Human Lung Cancer

Autofluorescence Imaging and Spectroscopy of Human Lung Cancer

Cervical cancer detection by time-resolved spectra of blood components

Fluorescence Spectral Features of Blood Components of Pregnant Women

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