Fluorescence turn-on detection of fluoride using HPQ-silyl ether reactive probes and its in vivo application

A novel fluorescent off–on probe for the sensitive and selective detection of fluoride ions

“…[11][12][13][14][15] To date, uorescent probes based on various sensing mechanisms have been reported for the detection of F À , including the uoride-hydrogen bonding interaction, 16,17 boron-uoride complexion 18,19 and uoride induced chemical reaction. [20][21][22][23][24][25][26][27][28][29][30][31][32] Among them the rst two types of probes could only work in non-aqueous media or media with high percentage of organic solvent because the detection signal would be largely hindered in aqueous environment. 23,24 So the third strategy, that is uoride induced chemical reaction, has attracted much attention.…”

“…[20][21][22][23][24][25][26][27][28][29][30][31][32] Among them the rst two types of probes could only work in non-aqueous media or media with high percentage of organic solvent because the detection signal would be largely hindered in aqueous environment. 23,24 So the third strategy, that is uoride induced chemical reaction, has attracted much attention. Owing to the high affinity of F À towards silicon, several probes have been developed relying on the uoride-triggered cleavage of Si-O bond.…”

“…Owing to the high affinity of F À towards silicon, several probes have been developed relying on the uoride-triggered cleavage of Si-O bond. [20][21][22][24][25][26][27][28][29][30]32 Besides, dimethyl-phosphinothionyl groups, which have been utilized as the protecting groups for side chain phenolic OH of tyrosine in peptide synthesis, could also be easily removed by F À . 33,34 Thus dimethylphosphinothionyl group would be a potential recognition moiety for F À .…”

Highly Sensitive Ratiometric Fluorescent Paper Sensors for the Detection of Fluoride Ions

“…This was linear with the concentration of F – (Figure 3b; R 2 = 0.9961) with a detection limit of 73 nM (S/N = 3). 18−20 The fluorescence emission ratio ( F 512nm / F 406nm ) of probe II gradually decreased as different concentrations of F – (0, 5, 10, 15, 20, 25, 30, and 35 μM) were added (Figure 3c). The fluorescence emission ratio ( F 512nm / F 406nm ) of probe I was linear with the concentration of F – (Figure 3d; R 2 = 0.9952).…”

A simple colorimetric and ratiometric fluoride ion probe with large color change

“…[19][20][21][22] The concept of molecular engineering of uoride ion probes was highly dependent on its unusual chemical properties involving small ionic radius, [23][24][25] high charge density and hard Lewis basic nature. 26 So far, the recognition mechanisms involving B-F complexation, 27 F À -induced deprotonation through H-bonding, [28][29][30][31][32] F À -mediated desilylation of Si-O/Si-C bonds, [33][34][35][36][37] and intramolecular charge transfer have been demonstrated. 38 For naked-eye detection, it is signicant to design chemical probes with large color change toward uoride ion sensing.…”