Fluorescent activatable gadofullerene nanoprobes as NIR-MR dual-modal in vivo imaging contrast agent

Li, Cheng; Huang, Huan; Cui, Rongli; Li, Juan; Guo, Xihong; Yao, Huanli; Liu, Bing; Xu, Bo; Liu, Ying; Liu, Shuaichao; Dong, Jinquan; Xing, Gengmei; Sun, Baoyun

doi:10.1016/j.colsurfb.2018.07.026

Cited by 2 publications

(1 citation statement)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…To date, various hybrid contrast agents that can simultaneously improve the contrast enhancement of both FL and MR images have been developed. Most approaches used for the fabrication of these contrast agents are based on superparamagnetic iron oxide nanoparticles (SPIONs)/near-infrared (NIR) dyes, gadolinium (Gd)-integrated nanoparticles/NIR dyes, and manganese-based nanoparticles/NIR dyes [17][18][19]. Although these multimodal contrast agents have shown promising performance by enabling complementary imaging of various tumors, they could not perform as dual activatable probes that can switch the FL/MR dual contrast from an "OFF" state to an "ON" state by sensing specific signals in tumor tissues.…”

Section: Ivyspring International Publishermentioning

confidence: 99%

MnCO₃-mineralized polydopamine nanoparticles as an activatable theranostic agent for dual-modality imaging-guided photothermal therapy of cancers

Lee¹,

Lee²,

Lee³

et al. 2022

Theranostics

View full text Add to dashboard Cite

Background: Single imaging modality is still insufficient to evaluate the biological and anatomical structures of tumors with high accuracy and reliability. Generation of non-specific contrast, leading to a low target-to-background signal ratio, results in low imaging resolution and accuracy. Tumor environment-specific activatable multifunctional contrast agents need to maximize the contrast signals, representing a dual imaging-guided photothermal therapy (PTT) at target tumor sites. Methods: Cellular uptake, cytotoxicity assay, and in vitro photothermal conversion efficiency of MnCO3-mineralized fluorescent polydopamine nanoparticles (MnCO3-FPNPs) were evaluated using 4T1 breast cancer cells. In vivo dual-modality imaging was performed using IVIS imaging and a 4.7 T animal MRI systems after injection into 4T1 tumor-bearing nude mice. The effects of photothermal therapeutic through PTT were measured after irradiation with an 808 nm laser (1.5 W/cm 2 ) for 10 min, measuring the size of the tumors every 2 days. Results: At physiological pH (7.4), MnCO3-FPNP is efficiently quenched. Conversely, at acidic pH (5.4), the strong fluorescence (FL) is recovered due to the dissociation of Mn 2+ from the FPNPs. At pH 7.4, MnCO3-FPNP activity is silenced to enhance water proton relaxation due to unionized MnCO3 maintenance; conversely, at acidic pH (5.4), MnCO3-FPNPs efficiently release Mn 2+ ions, thereby resulting in T1-weighted magnetic resonance (MR) contrast enhancement. MnCO3-FPNPs display a promising diagnostic ability for 4T1 breast cancer xenograft models, as well as exhibit a high photothermal conversion efficiency. A successful tumor treatment via their photothermal activity is accomplished within 14 days. Conclusions: Our studies exhibited unique "OFF-ON" activation abilities in FL/MR dual imaging and PTT functions. This approach suggests that the MnCO3-FPNPs may serve as a useful platform for various mineralization-based multimodal imaging-guided PTT models for many cancer theranostic applications.

show abstract

Section: Ivyspring International Publishermentioning

confidence: 99%

MnCO₃-mineralized polydopamine nanoparticles as an activatable theranostic agent for dual-modality imaging-guided photothermal therapy of cancers

Lee¹,

Lee²,

Lee³

et al. 2022

Theranostics

View full text Add to dashboard Cite

show abstract

Large-scale one-pot synthesis of water-soluble and biocompatible upconversion nanoparticles for dual-modal imaging

Wang

Zhang

et al. 2021

Colloids and Surfaces B: Biointerfaces

View full text Add to dashboard Cite

Fluorescent activatable gadofullerene nanoprobes as NIR-MR dual-modal in vivo imaging contrast agent

Cited by 2 publications

References 40 publications

MnCO₃-mineralized polydopamine nanoparticles as an activatable theranostic agent for dual-modality imaging-guided photothermal therapy of cancers

MnCO₃-mineralized polydopamine nanoparticles as an activatable theranostic agent for dual-modality imaging-guided photothermal therapy of cancers

Large-scale one-pot synthesis of water-soluble and biocompatible upconversion nanoparticles for dual-modal imaging

Contact Info

Product

Resources

About

Fluorescent activatable gadofullerene nanoprobes as NIR-MR dual-modal in vivo imaging contrast agent

Cited by 2 publications

References 40 publications

MnCO3-mineralized polydopamine nanoparticles as an activatable theranostic agent for dual-modality imaging-guided photothermal therapy of cancers

MnCO3-mineralized polydopamine nanoparticles as an activatable theranostic agent for dual-modality imaging-guided photothermal therapy of cancers

Large-scale one-pot synthesis of water-soluble and biocompatible upconversion nanoparticles for dual-modal imaging

Contact Info

Product

Resources

About

MnCO₃-mineralized polydopamine nanoparticles as an activatable theranostic agent for dual-modality imaging-guided photothermal therapy of cancers

MnCO₃-mineralized polydopamine nanoparticles as an activatable theranostic agent for dual-modality imaging-guided photothermal therapy of cancers