Fluorescent advanced glycation end products in type 2 diabetes and its association with diabetes duration, hemoglobin A1c, and diabetic complications

Li, Rui; Zhang, Mengyao; Xu, Lizhen; Liu, Jingjin; Yang, Pingan; Li, Min; Qin, Jie

doi:10.3389/fnut.2022.1083872

Cited by 7 publications

(3 citation statements)

References 56 publications

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“…The correspondence between dietary AGEs levels and AGEs levels in serum and tissue has been investigated earlier (Chen & Guo, 2021; Peppa & Mavroeidi, 2021; Scheijen et al, 2018). Studies suggest that, in patients with diabetes and renal failure, a significant correlation between dietary and circulating AGEs levels are observed (Liu et al, 2022; Rigalleau et al, 2015). In addition, after exogenous AGEs are ingested, these AGE‐modified proteins can interfere with normal cell‐matrix contacts or inhibit physiological cellular growth and intercellular contact that are necessary to maintain tissue integrity and normal function.…”

Section: Discussionmentioning

confidence: 99%

Effects of exogenous advanced glycation end products on oxidative stress and renal injury in healthy mice

Wen

Zhang

Xia

et al. 2023

eFood

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This study evaluated the biological effects of exogenous advanced glycation end products (AGEs) on the induction of chronic kidney disease and the dose‐effect relationship. Male C57BL/6 mice were placed on four diets, including saline and three other diets differing only in AGEs content (low‐AGEs [LA], medium‐AGEs [MA], and high‐AGEs [HA] ratio, 1:3:5) for 4 weeks. With the increasing intake of AGEs, mice developed a significant increase in blood glucose and lipid levels, the fluorescence intensity of AGEs, Nε‐(carboxymethyl)‐lysine, Nε‐(carboxyethyl)‐lysine, and malondialdehyde levels, whereas their superoxide dismutase activity and glutathione levels were decreased significantly. HA had the highest urinary protein levels and the lowest creatinine clearance compared to the other groups. These suggested that AGEs are an essential contributor to increasing oxidative stress levels and intake of high‐level AGEs induces more severe kidney function impairment. Meanwhile, the AGEs intake damaged the kidney structure in a dose‐dependent manner, as evidenced by granular degeneration of kidney tubular epithelial cells and inflammatory cell infiltration. These findings shed light on the detrimental impacts of AGEs on human kidneys, which also will help reveal a dose‐effect relationship of AGEs.

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Section: Discussionmentioning

confidence: 99%

Effects of exogenous advanced glycation end products on oxidative stress and renal injury in healthy mice

Wen

Zhang

Xia

et al. 2023

eFood

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“…Their accumulation from dietary and endogenous sources is in strong relationship with human diseases like cardiovascular, insulin resistance, etc. [22]. Not all AGEs are fluorescent, but the levels of fluorescent AGEs are indicators of diabetes complications [10,22].…”

Section: The Effect Of S Marianum Extract On Fructosamine Formationmentioning

confidence: 99%

The Inhibitory Effect of Silybum Marianum (Milk Thistle) Seeds Extract on Serum Albumin Glycation by Glucose, Fructose and Galactose

AL-SAEDI,

MERNEA,

ANGHELESCU

et al. 2023

Romanian J. Biophys.

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Protein glycation consists of the non-enzymatic attachment of monosaccharides to proteins. This leads to the formation of advanced glycation end products (AGEs) that are held responsible for diabetes complications. There are some drugs that inhibit AGEs, but their usage is limited by side effects. Plant-based therapeutic strategies could be useful in overcoming this limitation. Silybum marianum (Milk thistle), a plant used to treat liver problems, was also proved useful in the treatment of type 2 diabetes. Here we investigated the ability of S. marianum extract to inhibit the in vitro glycation of bovine serum albumin (BSA) by three physiologically relevant monosaccharides, namely glucose, fructose and galactose. BSA was glycated in the absence and in the presence of 0.1 %, 1 % and 5 % S. marianum seeds hydroalcoholic extract. Measurements on fructosamine, AGEs and amyloid cross-β structures formation showed that the plant extract inhibited these processes in the case of the three monosaccharides, especially in the case of glucose and galactose. The inhibition was dose- dependent and time-dependent. Our results demonstrate the ability of the plant extract to inhibit the in vitro glycation of BSA.

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“…[22]. Not all AGEs are fluorescent, but the levels of fluorescent AGEs are indicators of diabetes complications [10,22].…”

Section: The Effect Of S Marianum Extract On Fructosamine Formationmentioning

confidence: 99%

Untitled

2023

Romanian J. Biophys.

View full text Add to dashboard Cite

Protein glycation consists of the non-enzymatic attachment of monosaccharides to proteins. This leads to the formation of advanced glycation end products (AGEs) that are held responsible for diabetes complications. There are some drugs that inhibit AGEs, but their usage is limited by side effects. Plant-based therapeutic strategies could be useful in overcoming this limitation. Silybum marianum (Milk thistle), a plant used to treat liver problems, was also proved useful in the treatment of type 2 diabetes. Here we investigated the ability of S. marianum extract to inhibit the in vitro glycation of bovine serum albumin (BSA) by three physiologically relevant monosaccharides, namely glucose, fructose and galactose. BSA was glycated in the absence and in the presence of 0.1 %, 1 % and 5 % S. marianum seeds hydroalcoholic extract. Measurements on fructosamine, AGEs and amyloid cross-β structures formation showed that the plant extract inhibited these processes in the case of the three monosaccharides, especially in the case of glucose and galactose. The inhibition was dosedependent and time-dependent. Our results demonstrate the ability of the plant extract to inhibit the in vitro glycation of BSA.

show abstract

Fluorescent advanced glycation end products in type 2 diabetes and its association with diabetes duration, hemoglobin A1c, and diabetic complications

Cited by 7 publications

References 56 publications

Effects of exogenous advanced glycation end products on oxidative stress and renal injury in healthy mice

Effects of exogenous advanced glycation end products on oxidative stress and renal injury in healthy mice

The Inhibitory Effect of Silybum Marianum (Milk Thistle) Seeds Extract on Serum Albumin Glycation by Glucose, Fructose and Galactose

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