Fluorescent and Antibacterial Aminobenzeneboronic Acid (ABA)-Modified Gold Nanoclusters for Self-Monitoring Residual Dosage and Smart Wound Care

Abstract

The replacement of dressings may cause secondary damage to the wounds; thus, the real-time monitoring of the state of wound dressings is crucial for evaluating wound care processes. Herein, we report a smart dressing to selfmonitor residue nanomedicine on it during the application. We load aminobenzeneboronic acid (ABA)-modified gold nanoclusters (A-GNCs) on bacterial cellulose (BC) membranes as an antibacterial wound dressing to display the amount of residual nanomedicine (A-GNCs) by in situ colorimetry during the application in remedying multi-drug-resistant (MDR) bacteriainfected wounds. A-GNCs emit bright orange fluorescence under UV light, whereas the BC membrane is transparent at a humidified state on the wounds. Thus, the BC-A-GNCs nanocomposite (BGN) shows decreasing intensity of orange fluorescence with the release of the A-GNCs, indicating the appropriate time points for the replacement of the dressing. The BGN, which can realize accurate self-monitoring in a simple, low-cost, and efficient way, thus holds great promise for broad clinical applications.

Nanobiotechnology: Applications in Chronic Wound Healing

“… 219 In order to avoid secondary wound damage caused by dressing changes, Jiang et al created bacterial cellulose-based membranes with aminobenzeneboronic acid-modified gold nanoclusters (A-GNCs), which could be used for treating wounds infected with multidrug-resistant bacteria. 220 A-GNCs emit bright orange fluorescence under UV light, and the intensity of this fluorescence decreases with the release of A-GNCs. This allows healthcare professionals to determine when the dressing needs to be replaced.…”

Antibacterial metal nanoclusters

“…The anti-biofilm activity of the coated AuNCs can be maintained for at least 3 months, even after repeated usage. In order to visually monitor nanotherapeutic-loaded wound dressings, a novel wound dressing by integrating the fluorescence of the nanotherapeutic and the transparency of the scaffold was developed [ 113 ]. During the bacteria-infected wound healing process, the fluorescence intensity of the therapeutic AuNCs in the transparent bacterial cellulose scaffolds decreases as the release of the nanotherapeutic into the wound, which indicates the replacement of the dressing when the residual concentration of the AuNCs is lower than the minimum inhibitory concentration (Fig.…”

“…Copyright (2020) American Chemical Society. f Schematic illustration of the bacterial cellulose scaffold loaded with aminobenzeneboronic acid (ABA)-modified AuNCs as antibacterial wound dressing to address the issue of MDR-infected skin wounds (Reprinted with permission from [ 113 ]. Copyright (2021) American Chemical Society) …”

Breathable and Stretchable Dressings for Accelerating Healing of Infected Wounds

“…[14] Moreover, BC has good mechanical properties under the condition of moisture and can be easily removed without secondary damage to wounds, which is conducive to the growth of new skin and is suitable for the rehabilitation of traumatized skin. [15] Thus, BC is a kind of ideal dressing materials for curing a wide range of wounds including deep burns, diabetic ulcers, bedsores, and full-thickness skin defects.…”