Fluorescent Antibodies in the Fluid of the Conjunctival Sac of Trachoma Patients

Bernkopf, H.; Orfila, J; Maythar, B.

doi:10.1038/209725a0

Cited by 11 publications

(2 citation statements)

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“…Similar results have been obtained with C. trachornatis in the owl monkey (Aotus trivirgatus) [6]. The presence of chlamydia-specific antibody in the ocular secretions of humans with trachoma was first demonstrated by Bernkopf and colleagues [7]. Nichols and colleagues showed that tears from children with trachoma would partly neutralize homologous strains of chlamydia inoculated into the owl monkey eye [8], but since chlamydia were present in conjunctival scrapings from these children it was clear that they themselves were not protected from infection.…”

Section: Introductionsupporting

confidence: 71%

The influence of local antichlamydial antibody on the acquisition and persistence of human ocular chlamydial infection: IgG antibodies are not protective

et al. 1993

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SUMMARYIn order to study the effect of antichlamydial antibodies in ocular secretions on resistance to ocular chlamydial infection and clearance of this infection, we have performed linked longitudinal studies in a Gambian village in which trachoma is endemic. We have measured IgG and IgA antibody levels to a local serotype B isolate of Chlamydia trachomatis by amplified enzyme immunoassay, and chlamydial antigen levels in conjunctival swabs using a commercially available immunoassav which detects chlamydial glycolipid. Having previously demonstrated that sharing a bedroom with a case of active trachoma is a risk factor for acquisition of the disease, we have analysed the effect of IgG and IgA antibody on the acquisition and persistance of clinical trachoma after controlling for age, sex, exposure to infection and for the presence of chlamydial antigen using a Poisson regression model. We have found that the presence of antichlamydial IgG in ocular secretions of disease-free subjects is associated with an increased incidence of trachoma. IgA antibody shows an opposite trend, but this is not statistically significant. One possible explanation of these findings is that antichlamydial IgG antibodies enhance the infectivity of C. trachomatis for the human eye; this could have major implications for the development of a chlamydial vaccine.

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Section: Introductionsupporting

confidence: 71%

The influence of local antichlamydial antibody on the acquisition and persistence of human ocular chlamydial infection: IgG antibodies are not protective

et al. 1993

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“…Locally produced antibodies against C. trachomatis were first described by Bernkopf et al [16] in 1966 in fluid from the conjunctival sac of infected individuals. The detection of local antibodies against C. trachomatis in cervical secretions has by some investigators been claimed to be of diagnostic values and a possible indica tor of current infection [1.2], while others have found the sensitivity and predictive values of the test too low for conclusions [3][4][5].…”

Section: Discussionmentioning

confidence: 99%

Immunoglobulin Contents in Cervical Secretions of Women with Chlamydial Cervicitis

Persson

Eneroth

Grillner

1990

Gynecol Obstet Invest

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Contents of albumin, IgG, IgA and secretory IgA (S-IgA) were determined in secretions of 16 women with chlamydial cervicitis (study group) and 13 women with vulvovaginal candidiasis (control group). The amounts of respective protein in cervical secretions were higher among the women with chlamydial infection representing both an increased transudation and an increased local production of antibodies in the infected cervix. Specific chlamydial antibodies of IgG, IgA and S-IgA class were found significantly more often in the study group. Comparing the IgG/IgA ratios in serum and secretions gave indications for an active local secretion of specific IgA antibodies. This was also supported by the demonstration of specific S-IgA.

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The immunopathology of trachoma: Some facts and fancies

Collier

1967

Archiv f Virusforschung

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Fluorescent Antibodies in the Fluid of the Conjunctival Sac of Trachoma Patients

Cited by 11 publications

References 3 publications

The influence of local antichlamydial antibody on the acquisition and persistence of human ocular chlamydial infection: IgG antibodies are not protective

The influence of local antichlamydial antibody on the acquisition and persistence of human ocular chlamydial infection: IgG antibodies are not protective

Immunoglobulin Contents in Cervical Secretions of Women with Chlamydial Cervicitis

The immunopathology of trachoma: Some facts and fancies

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