Fluorescent chemosensor for Al(III) based on chelation-induced fluorescence enhancement and its application in live cells imaging

Schiff Bases and Multidentate Organic Compounds as Fluorescent Sensors of Al3+: Photophysical, Fluorescent Bioimaging and the Mechanisms

“…A salicylidene-benzothiophen Schiff base (L44) also presented a significant fluorescence enhancement at 430 nm when Al 3 + was present, due to the chelation-induced fluorescence enhancement (CHEF) mechanism, without any interference from other tested metal ions. [114] The receptor was used for the detection of intracellular Al 3 + in A549 cell line, using confocal imaging microscpy, showing a significant intracellular fluorescence increase as the concentration of the metal increased and revealing the good cell membrane permeability of L44 (Figure 7).…”

“…L43 was applied for the detecting of trace Al 3+ in test strips, also, the low cytotoxicity and membrane‐permeable properties allowed to perform microscopy studies detecting low concertation Al 3+ in living HeLa cells, where an increase of intracellular fluorescence was observed. A salicylidene‐benzothiophen Schiff base ( L44 ) also presented a significant fluorescence enhancement at 430 nm when Al 3+ was present, due to the chelation‐induced fluorescence enhancement (CHEF) mechanism, without any interference from other tested metal ions [114] . The receptor was used for the detection of intracellular Al 3+ in A549 cell line, using confocal imaging microscpy, showing a significant intracellular fluorescence increase as the concentration of the metal increased and revealing the good cell membrane permeability of L44 (Figure 7).…”

The Colorimetric Sensor Based on Azobenzenes with Sulfonamide Group for Fluorine Ion and Moisture Detection in Organic Solvents

“…For the interaction of L1 , L2 and F − ion have occurred only in aprotic polar solvents, the protonation and deprotonation mechanism are recommended [42–43] . The sulfonamide groups act as anion binding sites with basic fluoride anion, and the apparent change in the color and UV‐vis spectra was observed along with the process of Bronsted acid‐base reaction.…”

“…For the interaction of L1, L2 and F À ion have occurred only in aprotic polar solvents, the protonation and deprotonation mechanism are recommended. [42][43] The sulfonamide groups act as anion binding sites with basic fluoride anion, and the apparent change in the color and UV-vis spectra was observed along with the process of Bronsted acid-base reaction. In order to prove the mechanism of proton transfer, the UV-vis spectra, 1 HNMR titration, DFT calculations and relative chemical reaction are used to give insight of the mechanism.…”

A pyridine‐dicarbohydrazide‐based chemosensor for detecting Al3+ by fluorescence turn‐on

“…Thus, fluorescent "turn-on" sensing would be due to chelation-enhanced fluorescence process. [55] In the complex form, nonradiative transitions like rotation and vibration diminished and radiative transition like fluorescence increased. Referring to diverse spectroscopic analyses and theoretical calculations, we present the plausible detection of TMC to Al 3+ (Scheme 2).…”