Fluorescent copper(II) complexes: The electron transfer mechanism, interaction with bovine serum albumin (BSA) and antibacterial activity

Hazra, Madhumita; Dolai, Tanushree; Pandey, Akhil; Dey, Subrata Kumar; Patra, Animesh

doi:10.1016/j.jscs.2014.02.009

Cited by 23 publications

(12 citation statements)

References 37 publications

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“…BSA at a concentration of 1.00 × 10 −6 M was prepared by dissolving the protein in CP buffer solution at pH 7.4. Using a molar absorption of 44 720 M −1 cm −1 at 280 nm, its concentration was determined spectrophotometrically on a Cary‐50 UV–visible spectrophotometer (Varian) . The stock solutions of the synthesized compounds (1.00 × 10 −3 M) were prepared by dissolving the compounds in dimethyl sulphoxide (DMSO).…”

Section: Methodsmentioning

confidence: 99%

Explication of bovine serum albumin binding with naphthyl hydroxamic acids using a multispectroscopic and molecular docking approach along with its antioxidant activity

et al. 2019

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In the present investigation, the protein-binding properties of naphthyl-based hydroxamic acids (HAs), N-1-naphthyllaurohydroxamic acid (1) and N-1-naphthyl-pmethylbenzohydroxamic acid (2) were studied using bovine serum albumin (BSA) and UV-visible spectroscopy, fluorescence spectroscopy, diffuse reflectance spectroscopy-Fourier transform infrared (DRS-FTIR), circular dichroism (CD), and cyclic voltammetry along with computational approaches, i.e. molecular docking.Alteration in the antioxidant activities of compound 1 and compound 2 during interaction with BSA was also studied. From the fluorescence studies, thermodynamic parameters such as Gibb's free energy (ΔG), entropy change (ΔS) and enthalpy change (ΔH) were calculated at five different temperatures (viz., 298, 303, 308, 313 or 318 K) for the HAs-BSA interaction. The results suggested that the binding process was enthalpy driven with dominating hydrogen bonds and van der Waals' interactions for both compounds. Warfarin (WF) and ibuprofen (IB) were used for competitive site-specific marker binding interaction and revealed that compound 1 and compound 2 were located in subdomain IIA (Sudlow's site I) on the BSA molecule. Conclusions based on above-applied techniques signify that various non-covalent forces were involved during the HAs-BSA interaction. Therefore the resulted HAs-BSA interaction manifested its effect in transportation, distribution and metabolism for the drug in the blood circulation system, therefore establishing HAs as a drug-like molecule. KEYWORDS bovine serum albumin (BSA), circular dichroism, fluorescence spectroscopy, molecular docking, naphthylhydroxamic acids

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Section: Methodsmentioning

confidence: 99%

Explication of bovine serum albumin binding with naphthyl hydroxamic acids using a multispectroscopic and molecular docking approach along with its antioxidant activity

et al. 2019

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“…It can be inferred that free radical scavenging activities of synthesized compound are concentration dependent. Correspondingly, Hazra et al . have indicated that all the metal complexes showed comparable or slightly less activity compared to that of standard.…”

Section: Resultsmentioning

confidence: 92%

Catalytic and biological valorization of a supramolecular mononuclear copper complex based 4‐aminopyridine

Hfidhi

Bkhairia

Atoui

et al. 2019

Applied Organom Chemis

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Hydrothermal reaction of copper bromide with 4‐aminopyridine in DMF solution yields a new mononuclear copper complex [Cu(C5H6N2)4]2Br.2(C3H7NO) abbreviated Cu‐4AP‐Br. The product was characterized, structurally, by single‐crystal X‐ray diffraction analysis and, thermally, by DSC‐ATG measurement. The inorganic–organic hybrid compound Cu‐4AP‐Br crystallizes in the centrosymmetric space group Pbcn, exhibiting a supramolecular network. Simultaneous DSC‐ATG analysis shows that this compound remains stable up to 100 °C and then performs a successive decompositions accompanied with endothermic peaks. The complex Cu‐4AP‐Br was applied as a catalyst in the Heck coupling reaction under ultrasonic irradiation in various reaction conditions. The yields, obtained for a short period of time, allow us to consider this complex, generating selectivity on the external position of styrene with a preference of the trans form over cis, as an excellent catalyst for this type of reaction. Interestingly, Cu‐4AP‐Br displayed important antibacterial (Gram‐positive and Gram‐negative) and antioxidant activities (β‐carotene bleaching inhibition, scavenging effect on DPPH free radical, and reducing power).

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“…However, emission intensity decreases upon addition of Cu 2+ ions, probably because of the formation a non-uorescent copper(II) complex or dynamic quenching. 28 The same competition experiments have been carried out for complexing with Fe 3+ ions (Fig. 6).…”

Section: Resultsmentioning

confidence: 99%

“…However, emission intensity decreases upon addition of Cu 2+ ions, probably because of the formation a non-fluorescent copper( ii ) complex or dynamic quenching. 28 …”

Section: Resultsmentioning

confidence: 99%

Meso-functionalization of calix[4]arene with 1,3,7-triazapyrene in the design of novel fluorophores with the dual target detection of Al³⁺ and Fe³⁺ cations

et al. 2021

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Fluorescent copper(II) complexes: The electron transfer mechanism, interaction with bovine serum albumin (BSA) and antibacterial activity

Cited by 23 publications

References 37 publications

Explication of bovine serum albumin binding with naphthyl hydroxamic acids using a multispectroscopic and molecular docking approach along with its antioxidant activity

Explication of bovine serum albumin binding with naphthyl hydroxamic acids using a multispectroscopic and molecular docking approach along with its antioxidant activity

Catalytic and biological valorization of a supramolecular mononuclear copper complex based 4‐aminopyridine

Meso-functionalization of calix[4]arene with 1,3,7-triazapyrene in the design of novel fluorophores with the dual target detection of Al³⁺ and Fe³⁺ cations

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Fluorescent copper(II) complexes: The electron transfer mechanism, interaction with bovine serum albumin (BSA) and antibacterial activity

Cited by 23 publications

References 37 publications

Explication of bovine serum albumin binding with naphthyl hydroxamic acids using a multispectroscopic and molecular docking approach along with its antioxidant activity

Explication of bovine serum albumin binding with naphthyl hydroxamic acids using a multispectroscopic and molecular docking approach along with its antioxidant activity

Catalytic and biological valorization of a supramolecular mononuclear copper complex based 4‐aminopyridine

Meso-functionalization of calix[4]arene with 1,3,7-triazapyrene in the design of novel fluorophores with the dual target detection of Al3+ and Fe3+ cations

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Meso-functionalization of calix[4]arene with 1,3,7-triazapyrene in the design of novel fluorophores with the dual target detection of Al³⁺ and Fe³⁺ cations