Fluorescent covalent organic framework as an ultrasensitive fluorescent probe for tyrosinase activity monitoring and inhibitor screening

Liu, Hongmei; Liu, Weiping; Li, Yue; Jiang, Xinxin; Wang, Sikai; Zhang, Guoqi; Luo, Xiaojun; Zhao, Yan

doi:10.1016/j.aca.2024.343026

Analytica Chimica Acta

2024

DOI: 10.1016/j.aca.2024.343026

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Fluorescent covalent organic framework as an ultrasensitive fluorescent probe for tyrosinase activity monitoring and inhibitor screening

Hongmei Liu,

Weiping Liu,

Yue Li

et al.

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2024

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Cited by 2 publications

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Synthesis and Biomedical Applications of Covalent Organic Frameworks for Disease Diagnosis and Therapy

Wang,

Liu,

Feng

et al. 2024

ChemBioChem

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Covalent organic frameworks (COFs) have emerged as a distinguished class of porous materials. Owing to their ability to be constructed through covalent bonds involving light elements, such as hydrogen, boron, carbon, nitrogen, and oxygen, COFs offer greater stability and lower cytotoxicity than metal organic frameworks do, addressing critical limitations in in vivo applications. Their unique attributes, such as high surface area, customizable pore sizes, and versatile surface functionalities, make them ideal for various biomedical applications. This review aims to provide an overview of the recent advancements in modern COFs for biomedical uses. First, a variety of methods for the synthesis of COFs are outlined, which ensures their suitability for medical use. Next, we delve into innovative biomedical applications, emphasizing their role in disease diagnostics and therapies. Finally, challenges, such as clinical translation, biocompatibility, and controlled drug release, are critically discussed, providing comprehensive insight into the potential of COFs in revolutionizing biomedical technologies. Overall, this review offers a comprehensive overview of COFs' capabilities and future prospects in enhancing biomedical technologies.

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Synthesis and Biomedical Applications of Covalent Organic Frameworks for Disease Diagnosis and Therapy

Wang,

Liu,

Feng

et al. 2024

ChemBioChem

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Tyrosinase Oxidative Cross-Linking in the Cell-Like Crowded Microenvironment for Visible Inhibitor Screening

Jiao,

Shang,

Wang

et al. 2024

ACS Appl. Mater. Interfaces

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Owing to many diseases and disorders being caused by dysfunctional or over/underexpressed enzymes, screening for inhibitors of pharmacologically relevant enzymes has emerged as a promising tool for drug discovery, clinical diagnostics, enzyme engineering, and other medical fields. However, despite the recent advances, most inhibitor screenings are still usually conducted in dilute media, at concentrations far from the media in which the enzymes are actually found, which may cause drugs to fail when translated to in vivo. Herein, we build a gel-like intracellular biological environment in vitro using a tyrosinase oxidative cross-linking hydrogel system that is closer to the real catalytic environment of enzymes. We report a straightforward and effective inhibitor evaluation strategy that can quickly compare the inhibitory strengths of inhibitors based on the principle that adding inhibitors causes color changes and mechanical changes in the system. Enabled by molecular docking, we further demonstrate the different performances of the inhibitors at different concentrations. By construction of the cell-like crowded environment in vitro, this system shows an appealing application prospect for new drug development.

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Fluorescent covalent organic framework as an ultrasensitive fluorescent probe for tyrosinase activity monitoring and inhibitor screening

Cited by 2 publications

References 40 publications

Synthesis and Biomedical Applications of Covalent Organic Frameworks for Disease Diagnosis and Therapy

Synthesis and Biomedical Applications of Covalent Organic Frameworks for Disease Diagnosis and Therapy

Tyrosinase Oxidative Cross-Linking in the Cell-Like Crowded Microenvironment for Visible Inhibitor Screening

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