Fluorescent Dendrimers As Sensors for Biologically Important Metal Cations

Abstract

The review presents fluorescence spectroscopic studies on the capacities of newly synthesized polypropyleneamine and polyamidoamine fluorescent dendrimers to detect biologically important metal ions. It has been shown that those fluorescent dendrimers whose periphery comprises 1,8-napthalimide fragments are highly sensitive to metal ions which are of great importance to the living organisms.

Surface Functionalization of Cotton Fabric with Fluorescent Dendrimers, Spectral Characterization, Cytotoxicity, Antimicrobial and Antitumor Activity

“…In our laboratory, we have started studies aimed at combining the properties of dendrimer molecules with those of 1,8-naphthalimide fluorophores. For this purpose, various dendrimer structures have been peripherally modified with 1,8-naphthalimide units [13]. The incorporation of a larger number of biologically active 1,8-naphthalimide units into one dendrimer molecule results in an increase in their activity.…”

Synthesis and spectral characterization of a new blue fluorescent tripod for detecting metal cations and protons

“…[21]. In our previous studies the photophysical properties of PAMAM and PPA type dendrimers modified with 1,8-naphthalimide fluorescence units have been investigated with regard for their sensor application for detection of metal ions and protons [22][23][24][25][26][27][28][29][30][31]. On the other hand dual emission fluorescent sensors for pH or metal ions are of great importance [21,[32][33][34][35].…”

Synthesis, spectral properties and antimicrobial activity of a new cationic water‐soluble pH‐dependent poly(propylene imine) dendrimer modified with 1,8‐naphthalimides

“…Dendrimers are a relatively new class of polymer material and have been studied extensively over recent years for their use in biomedicine [1][2][3] or to design sensor systems. [4,5] They are nanosized compounds with a well defined chemical structure and monodispersed three-dimensional globular forms, characterized by their combining of the properties of low-and high-molecular-weight compounds. The large number of functional groups in the dendrimer molecules allows them to be modified with antimicrobial compounds and, as a result, their microbial resistance was reduced compared with standard antibiotics.…”

“…[10][11] Derivatives of 1,8-naphthalimide with different substituents on the C-4 atom have been used for peripheral modification of poly(propylene imine) (PPI) or polyamidoamine (PAMAM) dendrimers as high-performance metal ion detection sensors. [5] These dendrimers react to a change in fluorescence intensity when the pH of the medium changes, making them highly sensitive pH sensors. [12][13][14][15] Because the monomeric 1,8-naphthalimide compounds also exhibit biological activity, we have studied the antimicrobial and anticancer activity of PAMAM and PPI dendrimers and their metal complexes modified with 1,8-naphthalimides.…”