Fluorescent determination of poly(hexamethylene guanidine) via the aggregates it forms with quantum dots and magnetic nanoparticles

Imaging-Guided Delivery of a Hydrophilic Drug to Eukaryotic Cells Based on Its Hydrophobic Ion Pairing with Poly(hexamethylene guanidine) in a Maleated Chitosan Carrier

“…This compound is prepared by polycondensation of hexamethylenediamine and guanidine hydrochloride that yields weakly branched oligomers of a low molecular weight (up to 2 kDa, or a polymerization degree of 10-15) with amino or guanidine as terminal groups [27]. The pKa of protonated PHMG is 12.5, which makes it a polycation over a wide pH range (up to 12) [28], which is suitable for obtaining hydrophobic ion pairs with the drug. PHMG is known to be a potent antimicrobial agent: its 1 ppm aqueous solution exhibits an antibacterial activity above 90% [27].…”

“…[27]. The pKa of protonated PHMG is 12.5, which makes it a polycation over a wide pH range (up to 12) [28], which is suitable for obtaining hydrophobic ion pairs with the drug. PHMG is known to be a potent antimicrobial agent: its 1 ppm aqueous solution exhibits an antibacterial activity above 90% [27].…”

“…In binary systems (dye-ceftriaxone and dye-PHMG), no emission enhancement is observed. Ceftriaxone is negatively charged (at physiological pH of 7.4 used in study, its charge is -1 [32]), while PHMG exists as a polycation over a wide pH range [28]. Ceftriaxone and PHMG form ionic aggregates containing hydrophobic domains due to PHMG alkyl chains and are capable of solubilizing the carbocyanine dye nanoparticles, similar to the ceftriaxone-cetyltrimethylammonium (CTAB) system studied in paper [21].…”

Detection of Hexavalent Chromium by Copper Sulfide Nanocomposites

“…It tends to strongly bind to negatively charged particles. 33 Herein, we prepared a novel solid phase adsorbent CuS nanocomposites. The strategy is built on the formation of hydrogen bonds between PHMG and SG, then self-assembly with nano-CuS, which forms a sandwich ternary composite by electrostatic attraction.…”

“…First, nano-CuS is one of the most important nanomaterials in transition metal sulfide and Cr­(VI) can be reduced to Cr­(III) by it. , Second, the silanol groups on the surface of SG behave like a weak acid, hence they can be wrapped by polar compounds through strong hydrogen bonds or dipole–dipole interactions. , Lastly, PHMG is a thermally stable cationic polymer with guanidyl and amidogen groups. It tends to strongly bind to negatively charged particles . Herein, we prepared a novel solid phase adsorbent CuS nanocomposites.…”