Abstract:Oxoanions such as carboxylates, phosphates, and sulfates
play important
roles in both chemistry and biology and are abundant on the cell surface.
We report on the synthesis and properties of a rationally designed
guanidinium-containing oxoanion binder, 1-guanidino-8-amino-2,7-diazacarbazole
(GADAC). GADAC binds to a carboxylate, phosphate, and sulfate in pure
water with affinities of 3.6 × 104, 1.1 × 103, and 4.2 × 103 M–1, respectively.
Like 2-azacarbazole, which is a natural product that enables scorpions
to… Show more
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