Fluorescent magnetic nanoparticles for cell labeling: Flux synthesis of manganite particles and novel functionalization of silica shell

Kačenka, M.; Kaman, Ondřej; Kikerlová, Soňa; Pavlů, Barbora; Jirák, Z.; Jirák, Daniel; Herynek, Vı́t; Černý, Jan; Chaput, Frédéric; Laurent, Sophie; Lukeš, Ivan

doi:10.1016/j.jcis.2015.01.071

Cited by 21 publications

(13 citation statements)

References 45 publications

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“…Different dyes have been used in the construction of core–shell systems, such as near‐infrared dyes (NIR), fluorescein isothiocyanate, rhodamines, carbon quantum dots (C‐Dots), and fluorescent polymers . However, to the best of our knowledge, the use of dyes that fluoresce in the visible region by excited‐state intramolecular proton transfer (ESIPT) has not been reported so far.…”

Section: Methodsmentioning

confidence: 99%

Iron Oxide Nanoparticles Labeled with an Excited‐State Intramolecular Proton Transfer Dye

et al. 2016

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Excited-state intramolecular proton transfer (ESIPT) is a particularly well known reaction that has been very little studied in magnetic environments. In this work, we report on the photophysical behavior of a known ESIPT dye of the benzothiazole class, when in solution with uncoated superparamagnetic iron oxide nanoparticles, and when grafted to silica-coated iron oxide nanoparticles. Uncoated iron oxide nanoparticles promoted the fluorescence quenching of the ESIPT dye, resulting from collisions during the lifetime of the excited state. The assembly of iron oxide nanoparticles with a shell of silica provided recovery of the ESIPT emission, due to the isolation promoted by the silica shell. The silica network gives protection against the fluorescence quenching of the dye, allowing the nanoparticles to act as a bimodal (optical and magnetic) imaging contrast agent with a large Stokes shift.

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Section: Methodsmentioning

confidence: 99%

Iron Oxide Nanoparticles Labeled with an Excited‐State Intramolecular Proton Transfer Dye

et al. 2016

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“…Hu et al conjugated these QDs with 18 F radioisotope and therefore QDs can act as PET/NIRF probes to get a better insight 88. In multicomponent oxides like La1 xSrx MnO 3 (LSMO), magnetic properties can be better tuned than the binary version‐iron oxides and when Kacˇenka et al coated LSMO with the silica shell to which rhodamine molecules were linked, highly stabilized bimodal probes with increased florescence durability and improved magnetic properties were created through the silica shell covering 89. Zhang et al created multi modal probes by loading micelles with Au NPs, an excellent CA for CT imaging, and AIE red dye, such that the features of the dye are undisturbed 90.…”

Section: Functionalization To Enhance Multimodal Imagingmentioning

confidence: 99%

Nanoparticle Functionalization and Its Potentials for Molecular Imaging

et al. 2016

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Functionalization enhances the properties and characteristics of nanoparticles through surface modification, and enables them to play a major role in the field of medicine. In molecular imaging, quality functional images are required with proper differentiation which can be seen with high contrast to obtain viable information. This review article discusses how functionalization enhances molecular imaging and enables multimodal imaging by which images with combination of functions particular to each modality can be obtained. This also explains how nanoparticles interacting at molecular level, when functionalized with molecules can target the cells of interest or substances with high specificity, reducing background signal and allowing simultaneous therapies to be carried out while imaging. Functionalization allows imaging for a prolonged period and enables to track the cells over a period of time. Recent researches and progress in functionalizing the nanoparticles to specifically enhance bioimaging with different modalities and their applications are reviewed in this article.

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“…They produce nanoparticles with a high density of crystal defects that are detrimental to magnetotransport and complicate the interpretation of catalytic properties. Some teams reported the use of molten inorganic salts as high temperature liquid media where manganite nanoparticles were formed ,. The particles were nevertheless poorly faceted and still exhibited crystal defects.…”

Section: Introductionmentioning

confidence: 99%

Versatile Molten Salt Synthesis of Manganite Perovskite Oxide Nanocrystals and Their Magnetic Properties

et al. 2019

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Manganite perovskite oxides exhibit a wide range of properties relevant for catalysis, energy conversion and spintronics. Such behaviors can be deeply modified at the nanoscale where confinement and surface effects may prevail. Interesting properties could then emerge from manganite perovskite nanocrystals, although their synthesis remains a challenge. The present study reports a versatile synthesis of manganite perovskite nanocrystals by using molten salts as high temperature liquids in the 600–750 °C range. Through X‐ray diffraction, X‐ray photoelectron spectroscopy, scanning and transmission electron microscopies, we show that many substitutions on the A perovskite site are within reach by applying the approach to La2/3Sr1/3MnO3, La2/3Ca1/3MnO3 and La1/3Pr1/3Ca1/3MnO3 cubic‐shape nanocrystals with diameter of 20, 22 and 38 nm, respectively. The magnetic properties of these nanocrystals are then investigated at 5 K, highlighting the coexistence of a ferromagnetic phase typical of the bulk, with disordered and non‐magnetic domains, which presumably arise from the nanoscale and surface effects.

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Fluorescent magnetic nanoparticles for cell labeling: Flux synthesis of manganite particles and novel functionalization of silica shell

Cited by 21 publications

References 45 publications

Iron Oxide Nanoparticles Labeled with an Excited‐State Intramolecular Proton Transfer Dye

Iron Oxide Nanoparticles Labeled with an Excited‐State Intramolecular Proton Transfer Dye

Nanoparticle Functionalization and Its Potentials for Molecular Imaging

Versatile Molten Salt Synthesis of Manganite Perovskite Oxide Nanocrystals and Their Magnetic Properties

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