Fluorescent Materials with Excellent Biocompatibility and Their Application in Bio-Sensing, Bio-Imaging

Zheng, Meng; Wang, Yalong; Zhang, Deteng; Zhu, Mingqiang

doi:10.3390/bios13100906

Biosensors

2023

DOI: 10.3390/bios13100906

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Fluorescent Materials with Excellent Biocompatibility and Their Application in Bio-Sensing, Bio-Imaging

Meng Zheng,

Yalong Wang,

Deteng Zhang

et al.

Abstract: Fluorescent materials have great potential for use in biomedical applications due to their ease of functionalization and tunable fluorescence color [...]

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Cited by 5 publications

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3‐Ethoxysalicylaldimine‐based symmetrical azine‐linked luminogen exhibiting ESIPT and bright orange colour AIE behaviour with live cell bioimaging application

Mathivanan,

Shanmugaraj,

Ilanchelian

et al. 2024

Luminescence

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Herein, we describe the design and development of a new cell‐permeable aggregation‐induced emission (AIE) active 3‐ethoxysalicylaldimine‐based symmetrical azine molecule HDBE. The synthesized compound underwent comprehensive investigation of different spectroscopic methods, like NMR, mass and single crystal X‐ray diffraction analysis. The fluorophore HDBE exhibited the bright orange colour AIE behaviour in THF–H2O mixture. The drastic enhancement of emission was achieved upon adding the water to the THF solution of HDBE, with a concentration of 90%. Along with the dynamic light scattering (DLS) and quantum yield measurements, the formation of aggregates was also verified by scanning electron microscopy (SEM) and transmission electron microscopy (TEM) analysis. Further, HDBE demonstrated excited state intramolecular proton transfer (ESIPT) characteristics in different polarity of solvents, which was corroborated by absorption, emission and lifetime spectroscopical investigations. The detailed scrutiny of X‐ray structure of HDBE displayed the two strong intramolecular hydrogen bonding interactions, while solid‐state fluorescent spectra showed dual emission that corresponds to enol and keto form confirming the ESIPT feature. Further, the synthesized AIE molecule was non‐toxic and cell‐permeable, making it easy to label as a biomarker in live HeLa cells via fluorescent bioimaging. These studies offer a quick and easy way to develop both AIE and ESIPT‐coupled molecules for live cell bioimaging applications.

show abstract

3‐Ethoxysalicylaldimine‐based symmetrical azine‐linked luminogen exhibiting ESIPT and bright orange colour AIE behaviour with live cell bioimaging application

Mathivanan,

Shanmugaraj,

Ilanchelian

et al. 2024

Luminescence

View full text Add to dashboard Cite

show abstract

Ionic liquid-functionalized carbon dots for inhibiting amyloid aggregation and oxidative stress

Wang,

Shao,

Fan

et al. 2024

J Mater Sci

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Stability and photophysical study of bright day light fluorescent material and its fabrication in laser patterning and LED application

Manivannan,

Prabakaran,

Patra

et al. 2025

Dyes and Pigments

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Fluorescent Materials with Excellent Biocompatibility and Their Application in Bio-Sensing, Bio-Imaging

Abstract: Fluorescent materials have great potential for use in biomedical applications due to their ease of functionalization and tunable fluorescence color [...]

Cited by 5 publications

References 16 publications

3‐Ethoxysalicylaldimine‐based symmetrical azine‐linked luminogen exhibiting ESIPT and bright orange colour AIE behaviour with live cell bioimaging application

3‐Ethoxysalicylaldimine‐based symmetrical azine‐linked luminogen exhibiting ESIPT and bright orange colour AIE behaviour with live cell bioimaging application

Ionic liquid-functionalized carbon dots for inhibiting amyloid aggregation and oxidative stress

Stability and photophysical study of bright day light fluorescent material and its fabrication in laser patterning and LED application

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