Fluorescent Molecular Logic Gates Using Microfluidic Devices

Kou, Songzi; Lee, Han Na; Noort, Danny van; Swamy, K. M.K.; Kim, So Hyun; Soh, Jung Hyun; Lee, Kang-Mu; Nam, Soonkeon; Yoon, Juyoung; Park, Sungsu

doi:10.1002/anie.200703813

Cited by 173 publications

(29 citation statements)

References 46 publications

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“…In fact, in these areas there are problems that can be solved by simple computations that are at hand for current molecular processors, and need to be addressed in places where a silicon-based computer cannot go (e.g., inside a cell or in a membrane) [57]. Examples include the encoding [58] and networking [59] of microscopic objects, parallel chemical analyses in microfluidic systems [60], control of the function of biomolecules [61], screening of receptors [62] and diagnostic markers [63], and intelligent drug delivery in vitro [64] and in vivo [65].…”

Section: Discussionmentioning

confidence: 99%

Binary Logic with Synthetic Molecular and Supramolecular Species

Semeraro

Baroncini

2012

Molecular and Supramolecular Information Processing

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Section: Discussionmentioning

confidence: 99%

Binary Logic with Synthetic Molecular and Supramolecular Species

Semeraro

Baroncini

2012

Molecular and Supramolecular Information Processing

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“…In addition, gate-togate communication with Fe II /Fe III as redox mediator could be shown. Other groups reported the implementation of logic gates in microfluidic devices [70] and their attachment to nanowires. [71] The compartmentalization of logic gates by attaching them to solid supports can also be achieved by integration in supramolecular membrane-like structures.…”

Section: Challenges Towards Molecular Computingmentioning

confidence: 99%

Digital Operations with Molecules - Advances, Challenges, and Perspectives

Pischel

2010

Aust. J. Chem.

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This Review gives a short introduction into molecular logic and focusses then on the latest advances in the field. With regard to complex logic circuits and functions, molecular devices for arithmetic processing (adders and subtractors), multiplexers/demultiplexers, and encoders/decoders are discussed. Further on, the concept of memory for data storage and sequential logic is considered together with the latest results on molecular keypad locks. Molecular logic has been often connected to the future aim of molecular computing. However, albeit the herein described approaches constitute a starting point, major challenges like concatenation of gates, solid state devices and compartmentalization, and alternative concepts (reversible logic, multivalued logic) are waiting ahead. These points are included, as well as a view on alternative applications of molecular logic in bio-inspired approaches, combinatorial chemistry, and materials science. Logic with Molecular Switches -IntroductionModern information technology is based on two simple numbers: 0 and 1. Electrical signals, which are processed in any computer, can take one of both states. In practice a threshold is defined, such that a very low signal value corresponds to 0 and a signal above this limit translates into a 1. This is also known as positive logic convention, while negative logic holds for the opposite scenario. Albeit we are generally biased to connect logic with computers and, therefore, electrical signals, the concept of logic is valid for any system that can distinguish between two or more discrete states for input and output signals. In the case of binary logic a simple bistable system is sufficient, no matter what type of signal is processed (inputs) and what type of answer (output) is generated. Thus, it is absolutely legitimate to consider, for example, photonic and chemical signals.Since early works on molecular chemosensors that change their fluorescence upon pH changes or addition of metal cations, [1][2][3][4][5][6][7][8][9][10] the design of photoionic molecular systems has become extremely popular. [11] Molecular architectures, which integrate a fluorophore signalling unit and a receptor for analyte (chemical input) recognition, have enjoyed preference because of their modular design and the rather straightforward prediction of their photophysical behaviour. With relatively few excited state communication mechanisms like photoinduced electron Uwe Pischel studied Chemistry at the Technical University Dresden and the Humboldt University Berlin, where he graduated in 1998. In 2001, he obtained his Ph.D. from the University of Basel under supervision of Professor Werner M. Nau. After a short postdoctoral stay at the Polytechnical University Valencia with Professor Miguel A. Miranda, he started his independent career as a group leader in 2003. Currently he holds a permanent position as Profesor Contratado Doctor of Organic Chemistry at the University of Huelva in the south of Spain. His main research interests are fluorescent molecular switches a...

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“…that employ fluorescence changes have been studied intensively using various inputs, such as pH, metal ions, and anions. The previous results on fluorescent chemosensors for sensing of ions have provided important tools for the development of molecular logic gates …”

Section: Introductionmentioning

confidence: 99%

Fluorescence‐based logic gate for sensing of Ca²⁺ and F⁻ ions using PVP crowned chrysene nanoparticles in aqueous medium

2017

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Polyvinyl pyrrolidone (PVP) crowned chrysene nanoparticles (CHYNPs) were prepared by using a reprecipitation method. Dynamic light scattering (DLS) and scanning electron microscope (SEM) studies indicate that the monodispersed spherical nanoparticles bear a negative charge on their surfaces. The bathochromic spectral shift in the UV-visible and fluorescence spectrum of CHYNPs from chrysene (CHY) in acetone solution supports the J- type aggregation of nanoparticles. The aggregation-induced enhanced emission of CHYNPs at 486 and 522 nm decreases by increasing the concentration of the Ca ion solution. It can display an ON-OFF type fluorescence response with high selectivity towards Ca ions aqueous medium. Furthermore, the in situ generated PVP-CHYNPs-Ca ensemble could recover the quenched fluorescence upon the addition of fluoride anions resulting in an OFF-ON type sensor. The present method has a correlation coefficient R = 0.988 with a detection limit of 1.22 μg/mL for Ca in the aqueous medium. The fluorescence changes of PVP crowned CHYNPs upon the addition of Ca and F can be utilized as an INHIBIT logic gate at the molecular level, using Ca and F chemical inputs and the fluorescence intensity signal as output.

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Fluorescent Molecular Logic Gates Using Microfluidic Devices

Cited by 173 publications

References 46 publications

Binary Logic with Synthetic Molecular and Supramolecular Species

Binary Logic with Synthetic Molecular and Supramolecular Species

Digital Operations with Molecules - Advances, Challenges, and Perspectives

Fluorescence‐based logic gate for sensing of Ca²⁺ and F⁻ ions using PVP crowned chrysene nanoparticles in aqueous medium

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Fluorescent Molecular Logic Gates Using Microfluidic Devices

Cited by 173 publications

References 46 publications

Binary Logic with Synthetic Molecular and Supramolecular Species

Binary Logic with Synthetic Molecular and Supramolecular Species

Digital Operations with Molecules - Advances, Challenges, and Perspectives

Fluorescence‐based logic gate for sensing of Ca2+ and F− ions using PVP crowned chrysene nanoparticles in aqueous medium

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Fluorescence‐based logic gate for sensing of Ca²⁺ and F⁻ ions using PVP crowned chrysene nanoparticles in aqueous medium