Fluorescent molecularly imprinted membranes as biosensor for the detection of target protein

Zhang, Xin; Yang, Shu; Jiang, Rui; Sun, Liquan; Pang, Siping; Luo, Aiqin

doi:10.1016/j.snb.2017.07.205

Cited by 68 publications

(20 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…They mentioned that the fluorescent quantum dots embedded membrane, which enables the optical readout characteristic and high selectivity within a membrane. They first optimized the experiment conditions and calculated the detection limit as 10.2 nM with a range from 1.0 × 10 −7 to 1.0 × 10 −6 M. They also calculated the recoveries of the imprinted membrane for lysozyme determination in real samples as 93–103% [108]. Göçenoğlu et al published a study about imprinted nanoparticle based SPR sensor system for uric acid recognition.…”

Section: Recent Advances In Molecularly Imprinted Polymer Based Sementioning

confidence: 99%

“…( a ) Synthesis of quantum dots embedded imprinted membranes and ( b ) scanning electron microscope images of paper and quantum dots based ion-imprinted polymers: (A) the bare, (B) quantum dots grafted on the glass fiber, (C) quantum dots; (D) ion-imprinted polymer; (E) ion-imprinted polymer bonded with the quantum dots; (F) ion-imprinted polymer and quantum dots bound on the glass fiber. Republished with permission from [108,110]; permission conveyed through the Copyright Clearance Center, Inc.…”

Section: Figurementioning

confidence: 99%

See 1 more Smart Citation

Molecularly Imprinted Polymer Based Sensors for Medical Applications

Saylan

Akgönüllü

Yavuz

et al. 2019

Sensors

233

106

View full text Add to dashboard Cite

Sensors have been extensively used owing to multiple advantages, including exceptional sensing performance, user-friendly operation, fast response, high sensitivity and specificity, portability, and real-time analysis. In recent years, efforts in sensor realm have expanded promptly, and it has already presented a broad range of applications in the fields of medical, pharmaceutical and environmental applications, food safety, and homeland security. In particular, molecularly imprinted polymer based sensors have created a fascinating horizon for surface modification techniques by forming specific recognition cavities for template molecules in the polymeric matrix. This method ensures a broad range of versatility to imprint a variety of biomolecules with different size, three dimensional structure, physical and chemical features. In contrast to complex and time-consuming laboratory surface modification methods, molecular imprinting offers a rapid, sensitive, inexpensive, easy-to-use, and highly selective approaches for sensing, and especially for the applications of diagnosis, screening, and theranostics. Due to its physical and chemical robustness, high stability, low-cost, and reusability features, molecularly imprinted polymer based sensors have become very attractive modalities for such applications with a sensitivity of minute structural changes in the structure of biomolecules. This review aims at discussing the principle of molecular imprinting method, the integration of molecularly imprinted polymers with sensing tools, the recent advances and strategies in molecular imprinting methodologies, their applications in medical, and future outlook on this concept.

show abstract

Section: Recent Advances In Molecularly Imprinted Polymer Based Sementioning

confidence: 99%

Section: Figurementioning

confidence: 99%

Molecularly Imprinted Polymer Based Sensors for Medical Applications

Saylan

Akgönüllü

Yavuz

et al. 2019

Sensors

233

106

View full text Add to dashboard Cite

show abstract

“…Compared with organic fluorescent dye, QDs are more photostable and can exhibit strong luminescence, wide excitation but sharp emission profile, which are size-dependent (Silvi and Credi, 2015). The most well-known QDs embedded in MI-FL sensors are cadmium (Cd) (Huy et al, 2014;Liu et al, 2014b) and zinc (Zn) based (Chantada-Vázquez et al, 2016;Chen et al, 2017a;Li et al, 2017a;Zhang et al, 2018), and as we know, QDs synthesized using hydrophobic ligands such as trioctyl phosphine oxide (TOPO) can endow QDs with excellent quantum yield and chemical stability, but limit their hydrophilic applications. Using a reverse microemulsion polymerization, Liu et al (2014b) embedded the hydrophobic TOPO-modified CdSe QDs into the MI-FL sensor using cyclohexane as a continuous phase and Triton X-100 as a surfactant, obtaining both high quantum yield and hydrophilic applicability for ractopamine detection.…”

Section: Embedding Of Fluorescence Substancesmentioning

confidence: 99%

Strategies of molecular imprinting-based fluorescence sensors for chemical and biological analysis

Yang

Wang

et al. 2018

Biosensors and Bioelectronics

327

126

View full text Add to dashboard Cite

One pressing concern today is to construct sensors that can withstand various disturbances for highly selective and sensitive detecting trace analytes in complicated samples. Molecularly imprinted polymers (MIPs) with tailor-made binding sites are preferred to be recognition elements in sensors for effective targets detection, and fluorescence measurement assists in highly sensitive detection and user-friendly control. Accordingly, molecular imprinting-based fluorescence sensors (MI-FL sensors) have attracted great research interest in many fields such as chemical and biological analysis. Herein, we comprehensively review the recent advances in MI-FL sensors construction and applications, giving insights on sensing principles and signal transduction mechanisms, focusing on general construction strategies for intrinsically fluorescent or nonfluorescent analytes and improvement strategies in sensing performance, particularly in sensitivity. Construction strategies are well overviewed, mainly including the traditional indirect methods of competitive binding against pre-bound fluorescent indicators, employment of fluorescent functional monomers and embedding of fluorescence substances, and novel rational designs of hierarchical architecture (core-shell/hollow and mesoporous structures), post-imprinting modification, and ratiometric fluorescence detection. Furthermore, MI-FL sensor based microdevices are discussed, involving micromotors, test strips and microfluidics, which are more portable for rapid point-of-care detection and in-field diagnosing. Finally, the current challenges and future perspectives of MI-FL sensors are proposed.

show abstract

“…Those molecularly imprinted synthetic receptors have exhibited integrated properties, including high affinity, robustness, low production cost, and great specificity. As a result, they may serve as the promising candidate natural receptors [50] , [51] , [52] . Great advances have been attained in the fields of nanotechnology and polymer science, which have strengthened the performances of molecularly imprinted polymer (MIP) sensors.…”

Section: Introductionmentioning

confidence: 99%