Fluorescent nanodiamonds as enzyme mimics for protecting astrocytes from oxidative stress in a mouse model of epilepsy

Wang, Na; Zhang, Minru; Ma, Yanping; Liu, Shaoyan; Liu, Qianqian; Liao, Yonghua; Ding, Feng; Tian, Xiumei

doi:10.1007/s11051-021-05381-4

Cited by 3 publications

(2 citation statements)

References 50 publications

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“…Our findings are in agreement with the literature. [41][42][43] In previous studies, it has been reported that PTZ application triggers seizure formation by increasing oxidative stress and may cause damage to peripheral tissues. [23,44] To our knowledge, no studies were found investigating the effect of ARS on GSH, GSH-Px enzymes.…”

Section: Discussionmentioning

confidence: 99%

Deneysel Epileptik Nöbet Modelinde, Artemisinin'in Fare Kalp ve Akciğer Dokularında Oksidatif Stress Belirteçleri Üzerine Etkisi.

KOÇAK

Huyut

Türkan

et al. 2022

Journal of Contemporary Medicine

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Aim: The current study investigated the effects of artemisinin on the heart and lung tissue against pentylenetetrazol-induced seizures in mice. For this purpose, malondialdehyde (MDA), advanced oxidation protein products (AOPP), Catalase (CAT), glutathione (GSH), and glutathione peroxidase (GSH-Px) levels were evaluated in both tissue homogenates.Material and Method: Swiss albino male mice (n=42) were used in the experiment. Animals were divided into six groups; Control (C), pentylenetetrazol (PTZ), valproate 100 mg/kg (VPA), artemisinin 30 mg/kg (ARS)+PTZ, ARS 60 mg/kg+PTZ, ARS 120 mg/kg+PTZ. On the 26th day of the experiment, the mice were sacrificed and the samples were kept at -80 0C for biochemical analysis.Results: There were significant differences in the five biochemical parameters analyzed in heart and lung tissues. Heart and lung MDA levels of the PTZ group were found to be significantly higher than the C and ARS-60 groups (p<0.05). Heart and lung MDA levels of the PTZ group were found to be significantly higher than the C and ARS-60 groups. Likewise, heart AOPP levels decreased significantly in the VPA and ARS-60 groups compared to the PTZ group (p<0.05). There was no significant difference between the groups in terms of lung AOPP levels (p>0.05). Heart CAT and GSH levels were decreased in the PTZ group compared to the other groups. However, in terms of Lung CAT levels, the PTZ group had the highest value compared to the other groups, while it had the lowest value in terms of GSH level. The GSH-Px level did not differ significantly between the groups in heart tissue (p>0.05). The lung GSH-Px level was significantly increased in the ARS-30 group when compared to the PTZ group (p<0.05).Conclusion: Consequently ARS treatment can inhibit PTZ-induced oxidative stress in peripheral tissues. In addition, ARS may provide improvements in decreased antioxidant enzymes. ARS may contribute to the antioxidant defense system.

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Section: Discussionmentioning

confidence: 99%

Deneysel Epileptik Nöbet Modelinde, Artemisinin'in Fare Kalp ve Akciğer Dokularında Oksidatif Stress Belirteçleri Üzerine Etkisi.

KOÇAK

Huyut

Türkan

et al. 2022

Journal of Contemporary Medicine

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“…In addition to naturally occurring rhodopsin, radicicicin, and cyanophyllum fruit extract, irisin, fluorescent nanodiamond, and other materials with anti-oxidative stress demonstrated anti-epileptic effect. [99][100][101][102][103] Metal oxides like MgO and ZnO have shown potential antiepileptic abilities, although their mechanisms of action are not yet clear.…”

Section: Novel Pharmaceutical Bioinorganic Materials For Epilepsy The...mentioning

confidence: 99%

Bioinorganic Materials for Imaging, Diagnosis and Therapy of Neurological Disease

Zhao,

Ngai,

Wang

et al. 2024

Small Structures

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The treatment of neurological disease, such as epilepsy is rather complicated. Emerging therapies such as surgery, gene therapy, stem cell transplantation, and neurostimulation have been developed to replace traditional drug therapy. However, great challenges such as the difficult localization of epileptic foci (EF), incomplete excision of lesioned nerves, high drug resistance, and severe side effects limit their clinical applications. As an alternative, bioinorganic materials have been emerged and show great potentials for epilepsy theranostics. Their unique physical properties, including fluorescence, magnetic resonance effect, and surface‐enhanced Raman scattering effect (SERS), give them the ability to image the localization of EF. In addition, the fluorescence and conductivity of bioinorganic materials could be further used for studying pathogenesis. Moreover, bioinorganic materials could serve as intelligent systems to deliver drugs and cooperative therapy for epilepsy. Herein, this review highlights the design and application of bioinorganic materials in the imaging, diagnosis, and therapy of epilepsy. Furthermore, light is shown on the potential bottlenecks and future perspectives of bioinorganic materials in epilepsy theranostics.

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Nanozyme enabled protective therapy for neurological diseases

Cheng,

Kotha,

et al. 2024

Nano Today

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Fluorescent nanodiamonds as enzyme mimics for protecting astrocytes from oxidative stress in a mouse model of epilepsy

Cited by 3 publications

References 50 publications

Deneysel Epileptik Nöbet Modelinde, Artemisinin'in Fare Kalp ve Akciğer Dokularında Oksidatif Stress Belirteçleri Üzerine Etkisi.

Deneysel Epileptik Nöbet Modelinde, Artemisinin'in Fare Kalp ve Akciğer Dokularında Oksidatif Stress Belirteçleri Üzerine Etkisi.

Bioinorganic Materials for Imaging, Diagnosis and Therapy of Neurological Disease

Nanozyme enabled protective therapy for neurological diseases

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