Fluorescent nanoparticles from PEGylated polyfluorenes

Behrendt, Jonathan M.; Wang, Yun; Willcock, Helen; Wall, Laura; McCairn, Mark C.; O’Reilly, Rachel K.; Turner, Michael L.

doi:10.1039/c3py21068e

Cited by 11 publications

(12 citation statements)

References 15 publications

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“…We have recently reported that the bphase conformation of mixed phase poly(9,9-dioctyluorene) (PFO) nanoparticles, formed via nanoprecipitation, can be suppressed in a controllable fashion through use of PFO copolymers in which a proportion of the octyl side-chains have been substituted with hydrophilic poly(ethylene glycol) chains. 37 The absorption spectra of nanoparticles NP1-4 is shown in Fig. 5 (above).…”

Section: Spectral and Photophysical Characterisationmentioning

confidence: 99%

Hybrid inorganic–organic composite nanoparticles from crosslinkable polyfluorenes

et al. 2013

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Polyfluorenes with pendant alkoxysilyl groups have been used to prepare inorganic-organic composite nanoparticles (diameter ¼ 80-220 nm) in which the conjugated polymer is dispersed within a silica matrix. Preparation of these nanoparticles is achieved by simultaneous nanoprecipitation of the conjugated polymer and hydrolysis/crosslinking of the alkoxysilyl groups under basic conditions. The composition of the nanocomposites is controlled by addition of an alkoxysilane monomer, tetramethylorthosilicate. The hybrid nanoparticles form highly stable dispersions in water and buffer (pH 9.2). The size of the nanoparticles can be tuned by varying the amount of the alkoxysilane monomer added during the nanoprecipitation process. Increasing the relative amount of alkoxysilane monomer also increases the proportion of polyfluorene chains that adopt the higher energy b-phase conformation within the resultant nanoparticles. Nanoparticles with the highest silica content were found to have increased photoluminescence quantum yields. This work provides a controllable method for optimisation of the photophysical properties of light-emitting conjugated polymer nanoparticles via a simple aqueous processing technique.

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Section: Spectral and Photophysical Characterisationmentioning

confidence: 99%

Hybrid inorganic–organic composite nanoparticles from crosslinkable polyfluorenes

et al. 2013

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“…In recent years, water-soluble fluorescent -conjugated nanoparticles (WCPNs) have received much attention in bioimaging [1][2][3][4], drug-delivery, and sensing applications due to their high fluorescent brightness, excellent biocompatibility, and photostability [5][6][7]. The preparation of WCPNs was mainly focused on self-assembly method, because this method could retain the physical properties of the polymers.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of Water-Soluble Iridium (III)-Containing Nanoparticles for Biological Applications

Hou

Sun

Fan

et al. 2015

Journal of Chemistry

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Water-soluble nanoparticles (Ir/PGlc-NP, Ir/β-1,3-glucan-NP) based on water-soluble glycopolymers (PGlc),β-1,3-glucan polysaccharide, and conjugated phosphorescent Ir (III) complexes were successfully synthesized by self-assembly. The obtained nanoparticles have good spherical morphological characterization with a mean diameter of 50 nm measured by TEM. Ir/PGlc-NP and Ir/β-1,3-glucan-NP showed the same emission maxima at 565 nm in aqueous solution and both caused effective apoptosis and death of HepG2 and Hela cells after being irradiated at 445 nm for 30 min in vitro. Fluorescence cellular imaging was conducted by confocal laser scanning microscopy (CLSM) using HepG2 cells as the model cell in which the nanoparticles had successfully entered into the cytoplasm with high brightness. Furthermore, after injecting the nanoparticles into live mice in vivo, the real-time fluorescence imaging as well as the nanoparticles distribution in organs at 24 hours after administration indicated that these nanoparticles can serve as fluorescent imaging contrast for further biological applications.

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“…Several methodologies have been developed for the fabrication of conjugated polymer nanoparticles (CPNs) . Precipitation or emulsion techniques have been used for the synthesis of CPNs using as prepared polymers . Direct fabrication of nanoparticles can also be achieved by polymerization in dispersing heterophase systems .…”

Section: Introductionmentioning

confidence: 99%

Conjugated Polymer Nanoparticle‐Triplet Emitter Hybrids in Aqueous Dispersion: Fabrication and Fluorescence Quenching Behavior

Bandyopadhyay

Métivier

Pallavi

et al. 2015

Macromol. Rapid Commun.

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Conjugated polymer nanoparticles based on poly[9,9-bis(2-ethylhexyl)fluorene] and poly[N-(2,4,6-trimethylphenyl)-N,N-diphenylamine)-4,4'-diyl] are fabricated using anionic surfactant sodium dodecylsulphate in water by miniemulsion technique. Average diameters of polyfluorene and polytriarylamine nanoparticles range from 70 to 100 and 100 to 140 nm, respectively. The surface of the nanoparticles is decorated with triplet emitting dye, tris(2,2'-bipyridyl)ruthenium(II) chloride. Intriguing photophysics of aqueous dispersions of these hybrid nanoparticles is investigated. Nearly 50% quenching of fluorescence is observed in the case of dye-coated polyfluorene nanoparticles; excitation energy transfer is found to be the dominant quenching mechanism. On the other hand, nearly complete quenching of emission is noticed in polytriarylamine nanoparticle-dye hybrids. It is proposed that the excited state electron transfer from the electron-rich polytriarylamine donor polymer to Ru complex leads to the complete quenching of emission of polytriarylamine nanoparticles. The current study offers promising avenues for developing aqueous solution processed-electroluminescent devices involving a conjugated polymer nanoparticle host and Ru or Ir-based triplet emitting dye as the guest.

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Fluorescent nanoparticles from PEGylated polyfluorenes

Cited by 11 publications

References 15 publications

Hybrid inorganic–organic composite nanoparticles from crosslinkable polyfluorenes

Hybrid inorganic–organic composite nanoparticles from crosslinkable polyfluorenes

Synthesis of Water-Soluble Iridium (III)-Containing Nanoparticles for Biological Applications

Conjugated Polymer Nanoparticle‐Triplet Emitter Hybrids in Aqueous Dispersion: Fabrication and Fluorescence Quenching Behavior

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