Fluorescent nanorods based on 9,10-distyrylanthracene (DSA) derivatives for efficient and long-term bioimaging

Han, Wei; Du, Yangyang; Song, Mingming; Sun, Kaiju; Xu, Bin; Yan, Fei; Tian, Wenjing

doi:10.1039/c9tb02883h

Cited by 10 publications

(2 citation statements)

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“…Recently, scientists have successfully developed a number of specific recognition fluorescent probes using different strategies, for example, through binding different identifying groups or changing the molecular structure by reaction with the target [ 18 , 19 ]. The organic semiconductor with high biocompatibility is widely used in biosensors [ 20 , 21 ], such as AIE (aggregation-induced emission) based probes.…”

Section: Introductionmentioning

confidence: 99%

Organic Semiconducting Nanoparticles for Biosensor: A Review

et al. 2023

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Highly bio-compatible organic semiconductors are widely used as biosensors, but their long-term stability can be compromised due to photo-degradation and structural instability. To address this issue, scientists have developed organic semiconductor nanoparticles (OSNs) by incorporating organic semiconductors into a stable framework or self-assembled structure. OSNs have shown excellent performance and can be used as high-resolution biosensors in modern medical and biological research. They have been used for a wide range of applications, such as detecting small biological molecules, nucleic acids, and enzyme levels, as well as vascular imaging, tumor localization, and more. In particular, OSNs can simulate fine particulate matters (PM2.5, indicating particulate matter with an aerodynamic diameter less than or equal to 2.5 μm) and can be used to study the biodistribution, clearance pathways, and health effects of such particles. However, there are still some problems that need to be solved, such as toxicity, metabolic mechanism, and fluorescence intensity. In this review, based on the structure and design strategies of OSNs, we introduce various types of OSNs-based biosensors with functional groups used as biosensors and discuss their applications in both in vitro and in vivo tracking. Finally, we also discuss the design strategies and potential future trends of OSNs-based biosensors. This review provides a theoretical scaffold for the design of high-performance OSNs-based biosensors and highlights important trends and future directions for their development and application.

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Section: Introductionmentioning

confidence: 99%

Organic Semiconducting Nanoparticles for Biosensor: A Review

et al. 2023

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“…Before responding to hydrogen peroxide, the dyad is weakly emissive, while in the presence of intrahepatic/intrarenal hydrogen peroxide, the dyad can simultaneously release the active drug DA for treating type II diabetes via SGLT2 inhibition as well as the NIR fluorophore for imaging the diabetic liver/kidney damages. Compared to visible light, NIR light has less absorption by hemoglobin and water as well as less autofluorescence by tissues; thus, NIR fluorescence imaging can achieve higher performance as opposed to visible-light fluorescence imaging. − In this study, the dyad was employed in the mouse model of type II diabetes, and both the NIR imaging and high efficacy against diabetes were realized.…”

Section: Introductionmentioning

confidence: 99%

Fluorophore-Dapagliflozin Dyad for Detecting Diabetic Liver/Kidney Damages via Fluorescent Imaging and Treating Diabetes via Inhibiting SGLT2

Huang

Lin

et al. 2021

Anal. Chem.

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Type II diabetes is a prevalent disease; if left untreated, it could cause serious complications including liver and kidney damages. Hence, early diagnosis for these damages and effective treatment of diabetes are of high importance. Herein, a fluorophore-dapagliflozin dyad (DX-B-DA) has been developed as a theranostic system that can be triggered by intrahepatic/intrarenal reactive oxygen species (ROS) to concomitantly release a near-infrared (NIR) fluorescent dye (DX) and a SGLT2 inhibitor dapagliflozin (DA). In this dyad (DX-B-DA), the NIR fluorophore (DX) and the drug DA were covalently linked through a boronate ester bond which serves as the fluorescence quencher as well as the ROS-responsive moiety that can be cleaved by pathological levels of ROS in diabetics. The in vitro experiments indicate that, in the absence of hydrogen peroxide, the dyad is weakly emissive and keeps its drug moiety in an inactive state, while upon responding to hydrogen peroxide, the dyad simultaneously releases the NIR dye and the drug DA, suggesting that it can serve as an activatable probe for detecting and imaging diabetic liver/kidney damages as well as a prodrug for diabetes treatment upon being triggered by ROS. The dyad was then injected in mouse model of type II diabetes, and it is found that the dyad can not only offer visualized diagnosis for diabetes-induced liver/kidney damages but also exhibit high efficacy in treating type II diabetes and consequently ameliorating diabetic liver/kidney damages.

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