Fluorescent periodic mesoporous organosilica nanoparticles dual-functionalized via click chemistry for two-photon photodynamic therapy in cells

Abstract

International audienc

Mesoporous Silica and Organosilica Nanoparticles: Physical Chemistry, Biosafety, Delivery Strategies, and Biomedical Applications

“…Synthetic and extracting processes involving harsh pH and temperature conditions should also be compatible with the chemical stability of the organic bridges. The 25 min long ion exchange process involved with the simple sonication of the nonextracted MONs or PMO NPs with an ethanolic solution of ammonium nitrate a 45 °C is an efficient way to extract the nanomaterials …”

“…A wide array of click chemistry couplings were applied to functionalize effectively mesoporous organosilica materials as recently reviewed by Cattoën and co‐workers Wong Chi Man and co‐workers fabricated a library of organosilanes for click chemistry purposes . Click chemistry reactions were also carried out on MONs and PMO nanomaterials . Mesoporous organosilica were prepared from the N , N ‐bis(propargyl)triethoxysilylpropylamine precursor and successfully clicked various functions such as the thymine nucleobase .…”

“…DNA strands were also attached to silica via the copper‐catalyzed azide–alkyne cycloaddition (CuAAC) coupling . Azidopropyl functions pending into the pores of MONs and PMO NPs enabled the coupling of the MacMillan catalyst, [Fe III (biuret–amide)] catalytic complexes, photosensitizers for FRET transfer for photodynamic therapy, to name a few . The thiol–ene “click chemistry” postmodification was also reported on PMO materials (SiCH(CH 2 CHCH 2 )Si) .…”

Biodegradable Magnetic Silica@Iron Oxide Nanovectors with Ultra-Large Mesopores for High Protein Loading, Magnetothermal Release, and Delivery

“…[37] Silica NPs are slowly degraded in water by dissolution into biocompatible and bioadsorbed silicic acid products, [38] and silica NPs are renally excreted. [39][40][41] The unique properties of MSN and silica hybrid NPs have been implemented in catalysis, [37,42] separation, [43][44][45] bio-imaging, [33,[46][47][48] and in cargo delivery applications, [34][35][36][37][49][50][51] to name a few. Large-pore silica and silica hybrid NPs have also been designed for biomedical applications.…”

Engineering Hydrophobic Organosilica Nanoparticle-Doped Nanofibers for Enhanced and Fouling Resistant Membrane Distillation

“…PMO NPs are hybrid nano-objects with very high organic content (~30-70 wt%) and have thus higher properties than organically-doped silica NPs which have lower organic content (~1-30 wt%). [47][48][49][50] Although scalable and relatively cheap to produce, PMO NPs differ from conventional mesoporous silica by their tunable hydrophilicity/hydrophobicity along with many other properties that are associated with the type of organic bridges chosen for the design.…”