Fluorescent Phthalocyanine–Graphene Conjugate with Enhanced NIR Absorbance for Imaging and Multi-Modality Therapy

Pan, Jiabao; Yang, Yang; Fang, Wenjuan; Liu, Wei; Le, Kai; Xu, Dongmei; Li, Xiangzhi

doi:10.1021/acsanm.8b00449

Cited by 28 publications

(23 citation statements)

References 43 publications

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“…2 However, these therapies are associated with a number of disadvantages, such as damaging of healthy tissues, attacking of immune system, invasive, toxic side effects, poor tumor-selectivity, and limited efficacy. 2 Therefore, advanced therapies having high efficiency and precision are critically needed for cancer. One of the promising therapies is hyperthermia in which cancer cells are selectively targeted and destroyed by exposing to near-infrared (NIR)-mediated high temperature.…”

Section: Introductionmentioning

confidence: 99%

Cobalt Phthalocyanine-Sensitized Graphene–ZnO Composite: An Efficient Near-Infrared-Active Photothermal Agent

Neelgund

Oki

2019

ACS Omega

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Herein, a promising near-infrared-responsive photothermal agent was designed by anchoring of rice grain-shaped ZnO particles over graphene (GR) nanosheets and subsequent sensitization with cobalt phthalocyanine (CoPc). Thus, produced GR–ZnO–CoPc was able to attain the temperature of 68 °C by irradiating to 980 nm laser for 7 min, which is extremely higher than the endurance temperature of cancer cells. The linear fashioned progression in the photothermal effect of GR nanosheets was conquered by immobilization of ZnO particles and successive sensitization with CoPc. The excellence found in the photothermal effect of GR–ZnO–CoPc was verified by estimation of its photothermal conversion efficiency. The photothermal conversion efficiency assessed for GR–ZnO–CoPc was higher than those for the popular gold- and CuS-based photothermal agents. In addition, it possessed significant stability against photobleaching and structural rupture. It was found that the photothermal effect of GR–ZnO–CoPc is proportional to its concentration. However, by replacement of a 980 nm laser system with 808 nm, the photothermal effect of GR–ZnO–CoPc was reduced, which could be due to lower absorption of GR–ZnO–CoPc at 808 nm compared to 980 nm. On account of its significance and important properties, GR–ZnO–CoPc could be an interesting photothermal agent to employ in future photothermal therapy for cancer.

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Section: Introductionmentioning

confidence: 99%

Cobalt Phthalocyanine-Sensitized Graphene–ZnO Composite: An Efficient Near-Infrared-Active Photothermal Agent

Neelgund

Oki

2019

ACS Omega

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“…We measured 1 O 2 photogeneration to quantify the relative photodynamic effects of all compounds in the absence of tumour cells, by using 1,3‐diphenylisobenzofuran (DPBF) as a selective 1 O 2 acceptor (Figure ). All WSONs showed a slightly increased amount (4–13%) of 1 O 2 photogeneration compared to the corresponding free PS.…”

Section: Resultsmentioning

confidence: 99%

Mitochondria‐Targeted Water‐Soluble Organic Nanoparticles of Chlorin Derivatives for Biocompatible Photodynamic Therapy

Liu

Lee

et al. 2020

ChemNanoMat

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Photodynamic therapy (PDT) is a promising non‐invasive cancer therapy without any side‐effects. The photosensitizers (PSs) used in PDT are usually hydrophobic and not soluble in water. Water‐soluble PSs have been rarely studied in PDT research. Therefore, preparing water‐soluble PSs for clinical trials in PDT remains challenging. Here, we prepared water‐soluble organic nanoparticles (WSONs) using the following three chlorin derivatives: methyl pyropheophorbide a (MPPa), zinc metal‐introduced MPPa, and purpurin‐18 methyl ester. We used a very simple co‐precipitation method to develop WSONs through nanoprecipitation (solvent‐exchange) from THF to water. In this method, WSONs were developed in 87–112 nm sizes, based on TEM, with good water solubility and high water stability for more than a month. We evaluated intracellular accumulation and cell viability of these WSONs, exhibiting PDT results comparable to that of free PSs using HeLa cells. All WSONs were accumulated in mitochondria to induce mitochondria‐mediated apoptosis via effective PDT activity. This result is important not only for preparing WSONs with hydrophobic PSs to form highly water‐soluble PSs having good water stability in nanometre size, but also for retaining PDT activity with reduced dark toxicity, enabling potential applications for biocompatible PDT.

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“…Finally, purpurin-18- N -ethylamine (P18NEA, PS 1 ) was formed after removal of the Boc ( tert -butyloxycarbonyl) group from Boc-protected purpurinimide (P18NEAB). GO was prepared by a modified Hummer’s method [40], and was conjugated to PS 1 using amide formation with the terminal amine unit of the PS for covalent bonding [36,41,42,43,44] and supramolecular hydrophobic/π-π stacking interactions on the surface of sp 2 -bonded nanocarbons in GO for noncovalent bonding [29,37,39,45,46], resulting in two GO complexes: GO–PS 2 and GO–PS 3 , respectively (Scheme 1b).…”

Section: Resultsmentioning

confidence: 99%

“…To quantify the relative photodynamic effects of all compounds in the absence of tumor cells, 1 O 2 photogeneration was measured by 1,3-diphenylisobenzofuran (DPBF) as a selective 1 O 2 acceptor (Figure 6b) [43,52]. GO complex 2 exhibited higher 1 O 2 photogeneration compared with that of the free PS 1 .…”

Section: Resultsmentioning

confidence: 99%

Graphene Oxide Nanoparticles Having Long Wavelength Absorbing Chlorins for Highly-Enhanced Photodynamic Therapy with Reduced Dark Toxicity

Kang

Lee

Liu

et al. 2019

IJMS

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The long wavelength absorbing photosensitizer (PS) is important in allowing deeper penetration of near-infrared light into tumor tissue for photodynamic therapy (PDT). A suitable drug delivery vehicle is important to attain a sufficient concentration of PS at the tumor site. Presently, we developed graphene oxide (GO) nanoparticles containing long wavelength absorbing PS in the form of the chlorin derivative purpurin-18-N-ethylamine (maximum absorption wavelength [λmax] 707 nm). The GO–PS complexes comprised a delivery system in which PS was loaded by covalent and noncovalent bonding on the GO nanosheet. The two GO–PS complexes were fully characterized and compared concerning their synthesis, stability, cell viability, and dark toxicity. The GO–PS complexes produced significantly-enhanced PDT activity based on excellent drug delivery effect of GO compared with PS alone. In addition, the noncovalent GO–PS complex displayed higher photoactivity, corresponding with the pH-induced release of noncovalently-bound PS from the GO complex in the acidic environment of the cells. Furthermore, the noncovalently bound GO‒PS complex had no dark toxicity, as their highly organized structure prevented GO toxicity. We describe an excellent GO complex-based delivery system with significantly enhanced PDT with long wavelength absorbing PS, as well as reduced dark toxicity as a promising cancer treatment.

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Fluorescent Phthalocyanine–Graphene Conjugate with Enhanced NIR Absorbance for Imaging and Multi-Modality Therapy

Cited by 28 publications

References 43 publications

Cobalt Phthalocyanine-Sensitized Graphene–ZnO Composite: An Efficient Near-Infrared-Active Photothermal Agent

Cobalt Phthalocyanine-Sensitized Graphene–ZnO Composite: An Efficient Near-Infrared-Active Photothermal Agent

Mitochondria‐Targeted Water‐Soluble Organic Nanoparticles of Chlorin Derivatives for Biocompatible Photodynamic Therapy

Graphene Oxide Nanoparticles Having Long Wavelength Absorbing Chlorins for Highly-Enhanced Photodynamic Therapy with Reduced Dark Toxicity

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