Fluorescent sensing of monofunctional platinum species

Shen, Clara; Harris, Benjamin; Dawson, Lucy J.; Charles, Kellie A.; Hambley, Trevor W.; New, Elizabeth J.

doi:10.1039/c4cc08077g

Cited by 29 publications

(23 citation statements)

References 25 publications

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“…platinum with one labile ligand. [45] The complementarity of the two probes allows different platinum species to be detected, potentially allowing events such as aquation and DNA binding to be monitored in real time. While this approach has only been applied to platinumbased drugs so far, the potential to adapt fluo rescent probes to sense specific metal ions and coordination environments may allow the realtime detection of many metal based drugs without the need to alter their structure.…”

Section: Fluorescent Probes To Detect Metal Ionsmentioning

confidence: 99%

Spectroscopic Approaches to Tracking Metal-based Drugs in Cells and Tissue

Renfrew

2017

Chimia

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Metal-based drugs with novel targets and modes of action are increasingly being developed as alternatives to classical platinum(ii) chemotherapeutics. Imaging methods in tumour cells and tissues offer valuable insights into the behaviour of these novel complexes; however, mapping the distribution of metal ions and complexes within cellular environments remains challenging. The advantages and limitations of three modes of imaging: synchrotron radiation-induced X-ray fluorescence, mass spectrometry, and fluorescence microscopy are discussed in this review, with particular emphasis on their use in imaging ruthenium-based drugs.

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Section: Fluorescent Probes To Detect Metal Ionsmentioning

confidence: 99%

Spectroscopic Approaches to Tracking Metal-based Drugs in Cells and Tissue

Renfrew

2017

Chimia

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“…Mass spectrometry methods, for example, can pinpoint exactly a single isotope, but cannot report on the oxidation state or speciation of that isotope. On the other hand, fluorescent probes can be selective for individual oxidation states of metal ions, 60,61 or metal coordination environments, 62,63 but in some cases distinction of different analytes of similar properties is less straightforward. 64,65 Persistent incorrect interpretation of specificity can severely hamper research in a field.…”

Section: A Potential Difference: Integrating Analytical Chemistry Int...mentioning

confidence: 99%

On the outside looking in: redefining the role of analytical chemistry in the biosciences

Hare

New

2016

Chem. Commun.

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Biomedical research has moved on from the study of the structure of organs, cells and organelles. Today, the key questions that must be addressed to understand the body in health and disease are related to fundamental biochemistry: the distribution and speciation of chemicals, the regulation of chemical reactions, and the control of chemical environments. To see advances in this field, it is essential for analytical chemists to actively engage in this process, from beginning to end. In this Feature Article, we review the progress that has been made towards gaining an understanding of the chemistry of the body, while commenting on the intrinsic disconnect between new innovations in the field of analytical chemistry and practical application within the biosciences. We identify the challenges that prevent chemists from making a greater impact in this field, and highlight key steps for moving forward.

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“…New and co-workers reported a fluorescein-based probe linked to a dithiocarbamic acid moiety and a rhodamine-based probe incorporating phenyl isothiocyanate to study the metabolism of Pt II drugs. [11] Our group developed a rhodamine-based fluorescent turn-on probe as well as a FRETbased ratiometric derivative utilising dithiocarbamates as recog-nition motifs to study the intracellular activation of Pt IV carboxylate prodrug complexes in cells. [12] To date, these aforementioned small-molecule probes are the only reported fluorescent probes applied intracellularly to study Pt anticancer compounds.…”

Section: Introductionmentioning

confidence: 99%

Development of a Pre‐assembled Through‐Bond Energy Transfer (TBET) Fluorescent Probe for Ratiometric Sensing of Anticancer Platinum(ll) Complexes

Ong

Ang

2020

Chemistry An Asian Journal

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Fluorescence microscopy has emerged as an attractive technique to probe the intracellular processing of Pt-based anticancer compounds. Herein, we reported the first through-bond energy transfer (TBET) fluorescent probe NPR1 designed for sensitive detection and quantitation of Pt II complexes. The novel TBET probe was successfully applied for ratiometric fluorescence imaging of anticancer Pt II com-plexes such as cisplatin and JM118 in cells. Capitalizing on the ability of the probe to discriminate between Pt II complexes and their Pt IV derivatives, the probe was further applied to study the activation of Pt IV prodrug complexes that are known to release active Pt II species after intracellular reduction.[a] Dr.

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Fluorescent sensing of monofunctional platinum species

Cited by 29 publications

References 25 publications

Spectroscopic Approaches to Tracking Metal-based Drugs in Cells and Tissue

Spectroscopic Approaches to Tracking Metal-based Drugs in Cells and Tissue

On the outside looking in: redefining the role of analytical chemistry in the biosciences

Development of a Pre‐assembled Through‐Bond Energy Transfer (TBET) Fluorescent Probe for Ratiometric Sensing of Anticancer Platinum(ll) Complexes

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