Fluoreszenzbildgebung mit chemischen Sensoren

Schäferling, Michael

doi:10.1002/ange.201105459

Cited by 71 publications

(8 citation statements)

References 260 publications

(296 reference statements)

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“…The distance from the metal center to the equatorial water molecule is markedly larger (2.5581 (7) in Nd1, 2.5274 (6) in Eu1, and 2.5163 (5) in Tb1) than to the axial one (2.4643(5), 2.4210(4), and 2.3922(3) , respectively). This variation in the LnÀO bond lengths is in accordance with the differences in the interionic interactions linking the corresponding water molecules with the outer-sphere anions.…”

Section: Resultsmentioning

confidence: 96%

“…Indeed, the luminescence spectrum of Eu1 displays 5 D 0 ! 7 F J (J = 0-4) and 5 D 0 ! 7 F J (J = 0-2) transitions, with the magnetic dipole 5 D 0 !…”

Section: Resultsmentioning

confidence: 99%

“…Lanthanide (Ln) complexes are of special interest as perspective emissive components for new optical materials. [1][2][3][4][5] In the case of Eu 3 + and Tb 3 + ions, the presence of water molecules in their first coordination sphere, an occurrence that is sometimes inevitable, results in a quenching of luminescence owing to multiphonon nonradiative relaxation by OÀH oscillators. [6][7][8] This effect becomes more pronounced as a water molecule approaches the metal center.…”

Section: Introductionmentioning

confidence: 99%

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The Dark Side of Hydrogen Bonds in the Design of Optical Materials: A Charge‐Density Perspective

Nelyubina

Puntus

2014

Chemistry A European J

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A combined investigation of the structural, electronic, and optical properties of three crystalline nonaaqualanthanoid(III) triflates, [Ln(H2 O)9 (CF3 SO3 )3 ], has provided unambiguous experimental evidence for charge redistribution in the first coordination sphere of a lanthanide ion as a result of hydrogen bonds with outer-sphere anions. As well as resulting in charge transfer from the noncoordinated anions to the coordinated water molecules, these hydrogen bonds give rise to a new excited state, an hydrogen-bond-induced charge-transfer state, which is observed experimentally for the first time. This state was shown to be responsible for the previously unknown negative aspect of hydrogen bonds with a lanthanide-bound water molecule: rather than increasing the luminescence efficiency of the complex, they can lead to additional quenching that is unfavorable for the task-specific design of optical materials.

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Section: Resultsmentioning

confidence: 96%

“…Indeed, the luminescence spectrum of Eu1 displays 5 D 0 ! 7 F J (J = 0-4) and 5 D 0 ! 7 F J (J = 0-2) transitions, with the magnetic dipole 5 D 0 !…”

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The Dark Side of Hydrogen Bonds in the Design of Optical Materials: A Charge‐Density Perspective

Nelyubina

Puntus

2014

Chemistry A European J

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“…Außer der Zellmarkierung ist es auch mçglich, spezifische molekulare Sonden ("Sensoren") zu entwickeln, die ihre Lumineszenz in Gegenwart eines intrazellulären Analyten, wie Sauerstoff, ändern. [191] Wie kürzlich in einem Aufsatz dargelegt, [192] gibt es zahlreiche organische Fluorophore, die auf die Gegenwart unterschiedlicher Analyte reagieren. Die Entwicklung solcher von UCNPs abgeleiteten Sonden ist jedoch eine besonders anspruchsvolle Aufgabe, da sie normalerweise nicht auf ihre chemische Umgebung ansprechen.…”

Section: H H Gorris Und O S Wolfbeisunclassified

Photonen aufkonvertierende Nanopartikel zur optischen Codierung und zum Multiplexing von Zellen, Biomolekülen und Mikrosphären

Gorris

Wolfbeis

2013

Angewandte Chemie

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Photonen aufkonvertierende Nanopartikel (photon upconverting nanoparticles, UCNPs) sind Lanthanoid‐dotierte Nanokristalle, die unter Nahinfrarotanregung sichtbares Licht emittieren (Anti‐Stokes‐Emission). Diese einzigartige optische Eigenschaft schließt Hintergrundfluoreszenz und Lichtstreuung durch biologisches Material aus. Ein weiteres Kennzeichen der UCNPs ist die Emission von mehreren schmalen Emissionslinien, was neue Wege für die optische Codierung bereitet. Eindeutige Emissionssignaturen können erzielt werden, indem man die Mehrfachemission der UCNPs durch die Zusammensetzung der Dotanden oder durch eine Oberflächenmodifikation mit Farbstoffen einstellt. Wenn nur die Intensität einer Emissionslinie justiert wird, während eine weitere Emissionslinie als konstantes Referenzsignal fungiert, können ratiometrische Codes entwickelt werden, die unabhängig von Schwankungen der absoluten Signalintensitäten sind. Die Kombination mehrerer UCNPs, die jeweils durch ihre Kennung aus Emissionslinien eindeutig identifizierbar sind, erhöht den Umfang der Codierungen exponentiell und schafft so die Voraussetzungen zur Steigerung der Mehrfachdetektion von Analyten. Dieser Aufsatz zeigt das Potenzial der UCNPs zur Markierung und Codierung von Biomolekülen, Mikrosphären und sogar ganzen Zellen auf.

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“…[1][2][3] When compared to visible-light-emitting dyes, NIR fluorescent dyes are superior as imaging reagents as NIR light has minimum photodamage to biological samples, deep tissue penetration, and minimum interference from background autofluorescence by biomolecules in the biological samples. [4][5] The majority of NIR fluorescent dyes used for in vivo optical imaging belong to the cyanine dye family. Indocyanine green (ICG) is the first NIR fluorescent agent approved by the Food and Drug Administration (FDA) of the United States for clinical use.…”

Section: Introductionmentioning

confidence: 99%

Development of Unique Xanthene–Cyanine Fused Near‐Infrared Fluorescent Fluorophores with Superior Chemical Stability for Biological Fluorescence Imaging

Chen

Lin

Cui

et al. 2014

Chemistry A European J

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The development of near-infrared (NIR) functional fluorescent dyes has gained increasing attention over the last few decades. Herein, we describe the development of a unique type of xanthene-cyanine fused NIR fluorophores, XC dyes, formed by reacting chloro-substituted cyanine with resorcin or its analogues under anhydrous conditions. XC dyes are a hybrid of cyanine and xanthene. The preliminary mechanistic studies indicate that the formation of XC compounds likely includes a sequence of cyclization and oxidation. XC dyes have absorption and emission in the NIR region, and their fluorescence properties can be controlled by modifications of the key hydroxyl and amine groups. The novel XC NIR dyes are advantageous over previously developed merocyanine dyes NIR dyes in their chemical stability against strong nucleophiles. Quantum chemical calculations reveal that the distinct properties of XC and HD dyes can be attributed to their structural differences. By taking advantage of the superior properties of XC dyes, we have further constructed a new NIR fluorescent probe, XC-H2 S, which is capable of monitoring both the concentration- and time-dependent variations of H2 S in living animals, highlighting the value of XC NIR dyes. We expect that the unique XC NIR dyes developed herein will find broader applications than HD NIR dyes as fluorescent platforms for the development of a wide variety of NIR fluorescent probes, in particular, those suitable for targets of interest that have strong nucleophilic character.

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Fluoreszenzbildgebung mit chemischen Sensoren

Cited by 71 publications

References 260 publications

The Dark Side of Hydrogen Bonds in the Design of Optical Materials: A Charge‐Density Perspective

The Dark Side of Hydrogen Bonds in the Design of Optical Materials: A Charge‐Density Perspective

Photonen aufkonvertierende Nanopartikel zur optischen Codierung und zum Multiplexing von Zellen, Biomolekülen und Mikrosphären

Development of Unique Xanthene–Cyanine Fused Near‐Infrared Fluorescent Fluorophores with Superior Chemical Stability for Biological Fluorescence Imaging

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