Fluoride and Casein Phosphopeptide-Amorphous Calcium Phosphate

Reynolds, Eric C.; Cai, Fan; Cochrane, N.J.; Shen, Peiyan; Walker, G.; Morgan, Michael; Reynolds, Coralie

doi:10.1177/154405910808700420

Cited by 359 publications

(350 citation statements)

References 17 publications

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“…The crystal growth during remineralization has the same pattern as crystal growth during amelogenesis 27,28) . Microradiography has shown that CPP-ACP tends to remineralize throughout the lesion even in the presence of fluoride 29) .…”

Section: Discussionmentioning

confidence: 99%

Casein phosphopeptide-amorphous calcium phosphate and glass ionomer show distinct effects in the remineralization of proximal artificial caries lesion in situ

et al. 2013

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This study aimed to compare the ability of casein-phosphopeptide amorphous-calcium-phosphate (CPP-ACP) and glass-ionomer (GI) in remineralizing proximal artificial caries lesions (ACLs). Molar enamel-slabs were divided into: original-lesion control, intra-oral controls, and experimental (CPP-ACP or GI) groups. Specimens received ACLs and were bonded on subject maxillary first molars. After 4-weeks, mineral density (MD) was analyzed by μCT. Compared to control, CPP-ACP increased MD at 0-38/68-84 microns and the GI group had an increase at 0-68 microns, with a greater increase in MD compared to the CPP-ACP group from 0-53 microns. The mean percent remineralization (%R) showed differences between the GI, CPP-ACP groups and their paired controls. GI tended to increase remineralization more than CPP-ACP. In conclusion, CPP-ACP and GI demonstrated distinct remineralizing ability. GI induced greater remineralization in the superficial lesion, while CPP-ACP remineralized the lesion body. Their effects on percent remineralization and reducing lesion depth of proximal ACLs were similar.

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Section: Discussionmentioning

confidence: 99%

Casein phosphopeptide-amorphous calcium phosphate and glass ionomer show distinct effects in the remineralization of proximal artificial caries lesion in situ

et al. 2013

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“…6 If adequate amounts of salivary or plaque calcium and phosphate ions are available, the remineralization of previously demineralized enamel can be promoted by fluoride ions. 7 CPP-ACP, which is derived from milk casein, can also be used for remineralization. It has been shown that CPP-ACP increases the levels of calcium and phosphate ions significantly in supragingival plaque and promotes the remineralization of enamel subsurface lesions in situ.…”

Section: Introductionmentioning

confidence: 99%

Effects of remineralization procedures on shear bond strengths of brackets bonded to demineralized enamel surfaces with self-etch systems

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et al. 2015

The Angle Orthodontist

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Objective: To compare the effects of different remineralization procedures on the surface roughness of teeth, shear bond strengths (SBSs), and Adhesive Remnant Index scores of selfetching primer (SEP) used to bond orthodontic brackets to previously treated demineralized enamel surfaces. Materials and Methods: A total of 140 extracted human premolar teeth were randomly divided into seven equal groups. Group I was the control group. A demineralization procedure was performed in the other six groups. A remineralization procedure was performed before bonding by using casein phosphopeptide-amorphous calcium phosphate, fluoride, a microabrasion mixture (18% hydrochloric acid-fine pumice), a microabrasion agent, and resin infiltration in groups III to VII. Brackets were bonded using a self-etching primer/adhesive system. The specimens were tested for SBS. The roughness and morphology of the enamel surfaces were analyzed using profilometer and scanning electron microscopy. Data were analyzed with analysis of variance, Tukey, and G-tests at the a 5 .05 level. Results: Significant differences were found in the SBS values among the seven groups (F 5 32.69, P 5 .003). The lowest SBS value was found in group II (2.62 6 1.46 MPa). No significant differences were found between groups I, III, and VII, between groups III and IV, or between groups V and VI. The differences in the roughness values were statistically significant among the groups (P 5 .002). Conclusions: Remineralization procedures restore the decreased SBS of orthodontic brackets and decrease surface roughness caused by enamel demineralization. SEPs provide clinically acceptable SBS values for bonding orthodontic brackets to previously treated demineralized enamel surfaces. (Angle Orthod. 2016;86:661-667.)

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“…Como não há veículos para utilização do xilitol em mamadeiras ou para crianças pré-escolares e muito jovens 7 , as gomas de mascar e balas contendo xilitol podem ser utilizadas seguramente por mulheres grávidas e mulheres que estão amamentando 22 . O complexo fosfopeptídeo de caseína -fosfato de cálcio amorfo (CPP-ACP) tem sido amplamente estudado e considerado por diversos autores como um meio eficaz de prevenção da doença cárie e da erosão dental 12,[23][24][25][26] , visto a possibilidade de utilização de produtos à base de cálcio e fosfato na tentativa de aumentar a supersaturação destes elementos na saliva e biofilme. Constatou-se que as soluções ácidas tornam-se menos erosivas quando adicionadas de maior concentração destes dois componentes 27 .…”

Section: Figura 2 Distribuição Das Médias Do Ph Salivar Utilizando Ounclassified

“…Outros agentes modificadores também vêm sendo incorporados às gomas de mascar pelos seus fabricantes com o objetivo de minimizar o potencial erosivo da estrutura dentária, como o complexo fosfopeptídeo de caseína -fosfato de cálcio amorfo (CPP-ACP) 11 . Esses compostos à base de CPP-ACP foram lançados recentemente no mercado, com promissor potencial anticariogênico e cariostático pela liberação de íons cálcio e fosfato 12 .…”

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