Fluoride Exposure and Blood Pressure: a Systematic Review and Meta-Analysis

Li, Meng; Zhao, Yannan; Tian, Xiaolin; Liu, Penghui; Xie, Jiaxin; Dong, Nisha; Feng, Jing; Gao, Yi; Yu, Fan; Qiu, Yulan; Tian, Fengjie; Yan, Xiaoyan

doi:10.1007/s12011-020-02232-6

Cited by 14 publications

(6 citation statements)

References 39 publications

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“…Thus, further studies are needed to provide more clarity on potential associations between fluoride status and blood pressure among children and adolescents. Among adults, fluoride exposure has been associated with increased blood pressure in fluoride endemic areas [ 5 , 12 ], while biomarker studies from other areas are lacking and are needed before conclusions on a potential blood pressure increasing effect of moderate fluoride exposure can be drawn.…”

Section: Discussionmentioning

confidence: 99%

“…With respect to blood pressure, a recent systematic review of epidemiological studies indicated a positive association between fluoride exposure and elevated blood pressure among individuals from endemic fluorosis areas in Iran, Turkey and China [ 5 ], but not in other study populations. Again, the quality of the included study was graded as low because objective biomarkers measurements of fluoride status were lacking and potential confounders were not accounted for in the majority of studies [ 5 ]. The only identified study among children was a biomarker study in a well-characterised cross-sectional sample of children aged 10 to 18 years from Mexico City, a non-fluoride endemic area.…”

Section: Introductionmentioning

confidence: 99%

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Fluoride Status and Cardiometabolic Health: Findings from a Representative Survey among Children and Adolescents

et al. 2022

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There is preliminary evidence to suggest a positive association between fluoride exposure and higher blood pressure among children, but population-based biomarker studies are lacking. Thus, data from the 2013/2014 and 2015/2016 cycles of the US-based National Health and Nutrition Examination Survey (NHANES) were analysed to evaluate the association between plasma fluoride concentrations and blood pressure among children and adolescents aged 8 to 19 years. Secondary analyses were carried out on fluoride status in relation to further markers of cardio-metabolic health, i.e., anthropometric indices, biomarkers of lipid and sugar metabolism, and C-reactive protein levels. There was a positive correlation between water fluoride content and plasma fluoride concentrations (Spearman’s r = 0.41, p < 0.01). However, multivariable linear regression models did not show significant differences in adjusted mean values of systolic and diastolic blood pressure across increasing quartiles of fluoride concentrations. Further markers of cardio-metabolic health were not associated with fluoride status, with the exception of a weak inverse association between plasma fluoride and HbA1c levels. Higher plasma fluoride may not be a risk factor for increased blood pressure or impaired cardio-metabolic health among children in the USA, a non-fluoride endemic country, with wide-spread water fluoridation.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Fluoride Status and Cardiometabolic Health: Findings from a Representative Survey among Children and Adolescents

et al. 2022

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“…Neuronal damage from high fluoride exposure correlates with cellular oxidative stress and inflammation . Moreover, increased ROS levels have been noted in conditions like skeletal fluorosis, liver damage, and cardiovascular diseases caused by excessive intake of F – . − Some studies imply there is a potential link and the physiological relevance between F – and HClO. The increase in the levels of reactive oxygen species (ROS) was reported under the stimulation of F – in cells and organisms. , Among the ROS, hypochlorous acid (HClO) is a useful biomolecule synthesized from H 2 O 2 and Cl – , which is catalyzed by myeloperoxidase (MPO) .…”

Section: Introductionmentioning

confidence: 99%

Dual-Responsive Near-Infrared BODIPY-Based Fluorescent Probe for the Detection of F^– and HClO in Organisms

Mei,

Hai,

et al. 2024

Anal. Chem.

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Fluoride anions (F − ) play a crucial role in human physiological processes. However, excessive intake of F − would affect oxygen metabolism and promote the generation of oxygenfree radicals. Hence, it is essential to develop a precise and efficient fluorescent probe for visualizing F − -induced oxidative stress. In this work, we developed the first bifunctional BODIPY-based fluorescent probe dfBDP with p-tert-butyldimethylsilanolate benzyl thioether as the sensing site for the detection of F − and HClO via two distinct reactions, the self-immolative removal and the thioether oxidation, which generate the sensing products with two nonoverlap fluorescence bands: 800−1200 and 500−750 nm, respectively. The probe dfBDP displays rapid response, high specificity, and sensitivity for the detection of F − (LOD, 316.2 nM) and HClO (LOD, 33.9 nM) in vitro. Cellular imaging reveals a correlation between F − -induced oxidative stress and the upregulation of HClO. Finally, probe dfBDP was employed to detect F − and HClO in mice under the stimulation of F − . The experimental results display that the level of HClO elevates in the liver of mice.

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“…While many concerns regarding fluorination such as neurotoxicity, 24 bone fragility, and increased risk of bone cancer 25 – 27 have been largely disproven at the recommended levels of water fluoride concentration, there is little research exploring a possible link between fluoride and hypertension. A Chinese-based study 28 raised the possibility of a positive correlation between fluoride exposure and blood pressure (BP) while others did not find similar associations. A recent systematic review 29 also found that the evidence is suggestive but insufficient to establish a correlation between fluoride exposure and BP.…”

Section: Introductionmentioning

confidence: 99%

Association between fluoride exposure and blood pressure

Hung,

Mohajeri,

et al. 2023

Journal of Public Health Research

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Objectives: This study investigated whether fluoride was associated with an increased prevalence of high blood pressure (BP) among adolescents in the United States. Methods: The study sample consisted of 2015–2016 National Health and Nutrition Examination Survey participants aged 13–17 years. Independent-samples t-tests, Chi-square tests, and regression models were used to analyze the data. Results: A total of 814 participants met the study criteria. The findings showed that the proportion of patients with high levels of water or plasma fluoride in the high BP group was higher than that in the normal BP group. However, after adjusting for sociodemographic covariates, neither water nor plasma fluoride levels were significantly associated with a high BP. Conclusions: This study did not find an association between either water or plasma fluoride levels and high BP. Further study is needed to exclude a dose dependent effect at higher levels of fluoride.

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Fluoride Exposure and Blood Pressure: a Systematic Review and Meta-Analysis

Cited by 14 publications

References 39 publications

Fluoride Status and Cardiometabolic Health: Findings from a Representative Survey among Children and Adolescents

Fluoride Status and Cardiometabolic Health: Findings from a Representative Survey among Children and Adolescents

Dual-Responsive Near-Infrared BODIPY-Based Fluorescent Probe for the Detection of F^– and HClO in Organisms

Association between fluoride exposure and blood pressure

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Fluoride Exposure and Blood Pressure: a Systematic Review and Meta-Analysis

Cited by 14 publications

References 39 publications

Fluoride Status and Cardiometabolic Health: Findings from a Representative Survey among Children and Adolescents

Fluoride Status and Cardiometabolic Health: Findings from a Representative Survey among Children and Adolescents

Dual-Responsive Near-Infrared BODIPY-Based Fluorescent Probe for the Detection of F– and HClO in Organisms

Association between fluoride exposure and blood pressure

Contact Info

Product

Resources

About

Dual-Responsive Near-Infrared BODIPY-Based Fluorescent Probe for the Detection of F^– and HClO in Organisms