Fluoride in Dental Plaque and its Effects

Tatevossian, A.

doi:10.1177/00220345900690s126

Cited by 101 publications

(74 citation statements)

References 54 publications

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“…The baseline fluoride concentration in dental plaque was similar to that reported by Tatevossian [1990] for areas with suboptimal tap water fluoride levels. In the present study, a twofold increase was evident 2 h after the intake, which is comparable to results observed in plaque fluid immediately after the use of a fluoride rinsing solution [Ekstrand, 1997;Sjögren, 2001].…”

Section: Discussionsupporting

confidence: 83%

Fluoride Concentrations in Saliva and Dental Plaque in Young Children after Intake of Fluoridated Milk

Petersson

Arvidsson²,

Lynch³

et al. 2002

Caries Res

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This study determined fluoride (F) concentrations in whole saliva and dental plaque after intake of fluoridated milk using a randomised crossover experimental design. Eighteen healthy children (6–8 years) were subjected to each of four different 3-day drinking regimens: (a) 200 ml F-free tap water; (b) 200 ml tap water with 1.0 mg F; (c) 200 ml standard milk, and (d) 200 ml standard milk with 1.0 mg F. A washout period of 7 days was organised between the different drinking regimens. All children used F-free toothpaste prior to and during the trial and were instructed to avoid F-rich food and drinks. F concentration in unstimulated whole saliva was determined at baseline and after 15 and 120 min and in plaque samples at baseline and after 2 h. The mean baseline values ranged from 0.01 to 0.02 mg F/l in saliva and between 10.4 and 14.2 mg F/l in dental plaque. A statistically significant (p < 0.05) increase of F was disclosed in saliva 15 min after drinking F-containing milk and water (0.052 and 0.058 mg F/l, respectively). After 2 h, the salivary F^– concentrations were back to baseline values. In the plaque, however, a statistically significant (p < 0.01) twofold increase was found at 2 h after the intake of fluoridated milk and water, respectively. The results indicate that consumption of fluoridated milk contributes to a F storing process with significantly elevated F concentrations in dental plaque up to 2 h after intake. Further studies are required to determine the ‘therapeutic concentration’ of F in dental plaque after intake of fluoridated milk.

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Section: Discussionsupporting

confidence: 83%

Fluoride Concentrations in Saliva and Dental Plaque in Young Children after Intake of Fluoridated Milk

Petersson

Arvidsson²,

Lynch³

et al. 2002

Caries Res

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“…The exposure of structural materials to oral fluids, including acidic substances produced by bacterial metabolism, is associated to the corrosion of the implant fixture-abutment joint [16]. In addition, fluorides can be accumulated in biofilms depending on their structure and composition, physico-chemical properties of the solute, and biofilm thickness [96][97][98][99]. Due to the diffusion of F -ions through extracellular matrix, fluorides can also reach oral tissues and other micro-areas in the biofilm [96,97].…”

Section: Presence Of Oral Biofilmsmentioning

confidence: 99%

Wear and Corrosion Interactions on Titanium in Oral Environment: Literature Review

et al. 2015

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The oral cavity is a complex environment where corrosive substances from dietary, human saliva, and oral biofilms may accumulate in retentive areas of dental implant systems and prostheses promoting corrosion at their surfaces. Additionally, during mastication, micromovements may occur between prosthetic joints causing a relative motion between contacting surfaces, leading to wear. Both processes (wear and corrosion) result in a biotribocorrosion system once that occurs in contact with biological tissues and fluids. This review paper is focused on the aspects related to the corrosion and wear behavior of titanium-based structures in the oral environment. Furthermore, the clinical relevance of the oral environment is focused on the harmful effect that acidic substances and biofilms, formed in human saliva, may have on titanium surfaces. In fact, a progressive degradation of titanium by wear and corrosion (tribocorrosion) mechanisms can take place affecting the performance of titanium-based implant and prostheses. Also, the formation of wear debris and metallic ions due to the tribocorrosion phenomena can become toxic for human tissues. This review gathers knowledge from areas like materials sciences, microbiology, and dentistry contributing to a better understanding of bio-tribocorrosion processes in the oral environment.

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“…Fluoride inhibits demineralization and promotes remineralization of the tooth surface (ten Cate, 1999;Fejerskov, 2004). Fluoride is also known to inhibit bacterial acid production in vitro (Hamilton, 1990;Marquis, 1990;Jenkins, 1999) and plaque acid production in vivo (Tatevossian, 1990;Vogel et al, 2002). Competitive inhibition by fluoride of enolase, an enzyme in the Embden-Meyerhof-Parnas pathway (the EMP pathway) extracted from Streptococcus mutans and other plaque bacteria (Kaufmann and Bartholmes, 1992;Guha-Chowdhury et al, 1997), suggested that enolase is the target enzyme by fluoride inhibition.…”

Section: Introductionmentioning

confidence: 99%

Metabolomic Effects of Xylitol and Fluoride on Plaque Biofilm in Vivo

Takahashi

Washio

2011

J Dent Res

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Dental caries is initiated by demineralization of the tooth surface through acid production from sugar by plaque biofilm. Fluoride and xylitol have been used worldwide as caries-preventive reagents, based on in vitro-proven inhibitory mechanisms on bacterial acid production. We attempted to confirm the inhibitory mechanisms of fluoride and xylitol in vivo by performing metabolome analysis on the central carbon metabolism in supragingival plaque using the combination of capillary electrophoresis and a time-of-flight mass spectrometer. Fluoride (225 and 900 ppm F−) inhibited lactate production from 10% glucose by 34% and 46%, respectively, along with the increase in 3-phosphoglycerate and the decrease in phosphoenolpyruvate in the EMP pathway in supragingival plaque. These results confirmed that fluoride inhibited bacterial enolase in the EMP pathway and subsequently repressed acid production in vivo. In contrast, 10% xylitol had no effect on acid production and the metabolome profile in supragingival plaque, although xylitol 5-phosphate was produced. These results suggest that xylitol is not an inhibitor of plaque acid production but rather a non-fermentative sugar alcohol. Metabolome analyses of plaque biofilm can be applied for monitoring the efficacy of dietary components and medicines for plaque biofilm, leading to the development of effective plaque control.

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Fluoride in Dental Plaque and its Effects

Cited by 101 publications

References 54 publications

Fluoride Concentrations in Saliva and Dental Plaque in Young Children after Intake of Fluoridated Milk

Fluoride Concentrations in Saliva and Dental Plaque in Young Children after Intake of Fluoridated Milk

Wear and Corrosion Interactions on Titanium in Oral Environment: Literature Review

Metabolomic Effects of Xylitol and Fluoride on Plaque Biofilm in Vivo

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