“…Based on studies of several species, including hu mans, daily fluoride doses of about 0.1 mg/kg during tooth development are suf ficient to cause marginal dental fluorosis [Sum'eet al, 1972;Kruger, 1970;AngmarMansson et al, 1976;Forsman , 1977], It is, however, questionable whether a single value for fluoride intake can reliably pre dict dental fluorosis for all populations. Several studies have reported endemic in volvement in the apparent absence of ex cessive fluoride intake [Leatherwood et al, 1965;Nanda et al, 1974;Grahnen et al, 1974], Further, found developing enamel fluoride levels and the degree of rat incisor fluoro sis to be independent of or inversely relat ed to fluoride intake depending on acidbase status. They suggested that fluoride balance among individuals or populations could vary sufficiently to render intake da ta invalid as predictors of dental fluorosis.…”