Fluoride modification effects on osteoblast behavior and bone formation at TiO grit-blasted c.p. titanium endosseous implants

Cooper, Lyndon F.; Zhou, Yongsheng; Takebe, Jun; Guo, Juanli; Abron, Armin; Holmén, Anders; Ellingsen, Jan Eirik

doi:10.1016/j.biomaterials.2005.07.009

Cited by 358 publications

(289 citation statements)

References 51 publications

Supporting

Mentioning

261

Contrasting

Unclassified

Order By: Relevance

“…According to the literature, this combination of micro-and nanoroughness should be favorable in terms of osseointegration [17][18][19]. Besides, the increase in the fluorine content of the surface ( Figure 5) could enhance osteoblastic differentiation and interfacial bone formation as it does for titanium [68]. Finally, the selectively etched surface might reduce bacterial adhesion (Figure 7-c,d).…”

Section: Discussionmentioning

confidence: 99%

Selective etching of injection molded zirconia-toughened alumina: Towards osseointegrated and antibacterial ceramic implants

et al. 2016

View full text Add to dashboard Cite

Due to their outstanding mechanical properties and excellent biocompatibility, zirconiatoughened alumina (ZTA) ceramics have become the gold standard in orthopedics for the fabrication of ceramic bearing components over the last decade. However, ZTA is bioinert, which hampers its implantation in direct contact with bone. Furthermore, periprosthetic joint infections are now the leading cause of failure for joint arthroplasty prostheses. To address both issues, an improved surface design is required: a controlled micro-and nano-roughness can promote osseointegration and limit bacterial adhesion whereas surface porosity allows loading and delivery of antibacterial compounds. In this work, we developed an integrated strategy aiming to provide both osseointegrative and antibacterial properties to ZTA surfaces. The microtopography was controlled by injection molding. Meanwhile a novel process involving the selective dissolution of zirconia (selective etching) was used to produce nano-roughness and interconnected nanoporosity. Potential utilization of the porosity for loading and delivery of antibiotic molecules was demonstrated, and the impact of selective etching on mechanical properties and hydrothermal stability was shown to be limited. The combination of injection molding and selective etching thus appears promising for fabricating a new generation of ZTA components implantable in direct contact with bone.3

show abstract

Section: Discussionmentioning

confidence: 99%

Selective etching of injection molded zirconia-toughened alumina: Towards osseointegrated and antibacterial ceramic implants

et al. 2016

View full text Add to dashboard Cite

show abstract

“…Additionally, the incorporation of fluoride at the surface could enhance osteoblastic differentiation and interfacial bone formation, as it does for titanium [16]. Finally, zirconia dental implants with acid etched surface are already commercialized (CeraRoot implants with ICE™ surface) and apparently have shown a similar or higher success rate as compared to titanium implants after five years of follow-up [17].…”

Section: Introductionmentioning

confidence: 99%

Hydrofluoric acid etching of dental zirconia. Part 1: etching mechanism and surface characterization

Flamant

Marro

Rovira

et al. 2016

Journal of the European Ceramic Society

View full text Add to dashboard Cite

Rough surfaces have been shown to promote osseointegration, which is one of the keys for a successful dental implantation. Among the diverse treatments proposed to roughen zirconia, hydrofluoric acid (HF) etching appears to be a good candidate, however little is known about this process. In this work, the effect of HF concentration and etching time on the surface topography and chemistry of yttria-stabilized zirconia was assessed.Besides, to understand the etching mechanism, the reaction products present in solution and on the surface were characterized. The results indicate suitable parameters for a fast and uniform roughening of zirconia. The formation of adhered fluoride precipitates on the surface is reported for the first time and highlights the importance of cleaning after etching. Finally, it is shown that monitoring the time allows controlling the surface roughness, smooth-rough transition and fractal dimension, which should make possible the fabrication of implants with an optimal topography.

show abstract

“…Besides, Cooper et al (Cooper et al, 2006) found that the incorporation of fluoride at the surface of titanium implants could enhance osteoblastic differentiation and interfacial bone formation. More recently, Ito et al (Ito et al, 2013) showed that the combination of sandblasting with HF etching leads to an increase in the proliferation rate and expression of ALP activity of osteoblast-like cells (MC3T3-E1).…”

Section: Introductionmentioning

confidence: 99%

Surface roughened zirconia: towards hydrothermal stability

Camposilvan

Flamant

Anglada

2015

Journal of the Mechanical Behavior of Biomedical Materials

View full text Add to dashboard Cite

Surface roughness is needed in several yttria-stabilized zirconia components used in restorative dentistry for osseointegration or adhesion purposes. This can be achieved by different treatments, which may also modify the microstructure of the surface. Among them, sandblasting and chemical etching are widely used, but their effect on hydrothermal aging of zirconia is not fully understood. In the present work, the zirconia long-term stability of rough surfaces prepared by these techniques is analyzed and a method is proposed for preventing hydrothermal aging while maintaining the original surface appearance and mechanical properties. The method involves pressure infiltration of a Cerium salt solution on the roughened surfaces followed by a thermal treatment. The solution, trapped by surface defects and small pores, is decomposed during thermal treatment into Cerium oxide, which is diffused at high temperature, obtaining Ce co-doping in the near-surface region.In addition, the microstructural changes induced in the near-surface by sandblasting or chemical etching are removed by the thermal treatment together with surface defects. No color modification was observed and the final roughness parameters were in the range of existing implants of proved good osseointegration. The aging resistance of Ce co-doped materials was strongly enhanced, showing the absence of aging after artificial degradation, increasing in this way the surface mechanical integrity.The proposed treatment is easily applicable to the current manufacturing procedures of zirconia dental posts, abutments, crowns and dentures, representing a solution to hydrothermal aging in these and other biomedical applications.

show abstract

Fluoride modification effects on osteoblast behavior and bone formation at TiO grit-blasted c.p. titanium endosseous implants

Cited by 358 publications

References 51 publications

Selective etching of injection molded zirconia-toughened alumina: Towards osseointegrated and antibacterial ceramic implants

Selective etching of injection molded zirconia-toughened alumina: Towards osseointegrated and antibacterial ceramic implants

Hydrofluoric acid etching of dental zirconia. Part 1: etching mechanism and surface characterization

Surface roughened zirconia: towards hydrothermal stability

Contact Info

Product

Resources

About