Fluoride Release from Fluoride Varnishes under Acidic Conditions

Abstract

Objective: The aim was to investigate the in vitro fluoride release from fluoride varnishes under acidic conditions. Study design: Poly(methyl methacrylate) blocks (Perspex, n=3 per group) were painted with 80±5 mg fluoride varnish (n=10) and placed into artificial saliva for 30min. Then, blocks were placed into either 1% citric acid (pH 2.27) or 0.3% citric acid (pH 3.75) solutions (n=3 per solution and varnish) for 30min with the solutions being replaced every 5min. Saliva and acid solutions were analyzed for fluoride content. Data were analyzed using three-way ANOVA (varnish, solution, time). Results:The three-way interaction was significant (p<0.0001). Fluoride release and release patterns varied considerably between varnishes. Fluoride release in saliva varied by a factor of more than 10 between varnishes. Some varnishes (CavityShield, Nupro, ProFluorid, Vanish) showed higher fluoride release in saliva than during the first 5min of acid exposure, whereas other varnishes (Acclean, Enamel-Pro, MI Varnish, Vella) showed the opposite behavior. There was little difference between acidic solutions. Conclusions:Fluoride release from fluoride varnishes varies considerably and also depends on the dissolution medium. Bearing in mind the limitations of laboratory research, the consumption of acidic drinks after fluoride varnish application should be avoided to optimize the benefit/risk ratio.

Fluoride release from fluoride varnish under in vitro and in vivo conditions

“…Lippert observed that fluoride release from some fluoride varnishes varied considerably, and it was dependent on the pH of the dissolution medium. 23 Fluoride varnishes CavityShield, Nupro ® , ProFluorid ® and Vanish ® showed higher fluoride release to saliva than during the first 5 min of acid exposure, whereas other varnishes (Acclean ® , Enamel-Pro ® , MI Varnish, Vella ® ) revealed the opposite behavior. Our data also showed that the acidity of artificial saliva was associated with levels of fluoride release.…”

Fluoride Varnishes against Dental Erosion Caused by Soft Drink Combined with Pediatric Liquid Medicine

“…In the present study, the varnishes were applied once and removed after 6 h of application to simulate the clinical condition, since the emphasis was allowing the chemical effect of the varnish components, rather than the mechanical protection. Because of their common clinical use, high fluoride amount and slow components release, varnishes could be an ideal product to be used as a preventive product against dental erosion (21).…”

Substantive Fluoride Release from a New Fluoride Varnish Containing CXP

“…As tooth structure experiences fluoride reservoir dissolution with drops in pH, fluoride varnish performance at different pH may be of interest [12]. There are studies to indicate that some fluoride-containing products show an increase in release with a decrease in pH while others show a decrease in release with a decrease in pH [32,33]. Intuitively, a topical fluoride varnish with high initial fluoride release would allow for greater amounts of fluoride available for enamel uptake [30]; however, some studies have shown fluoride efficacy cannot be measured by the product's fluoride release rate [34].…”