Fluorine in Heterocyclic Chemistry Volume 2 2014
DOI: 10.1007/978-3-319-04435-4_5
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Fluorinated Pyrones, Chromones and Coumarins

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Cited by 11 publications
(2 citation statements)
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“…The ease of 4-CF 3 -2 H -chromene oxidation at the methylene group has led us to the idea of developing a new approach to the synthesis of practically important 4-CF 3 -coumarins. 20 The oxidation of the methylene group in compounds 2 to the keto group was carried out using CrO 3 in pyridine. 21 As a result, a whole series of 4-CF 3 -coumarins 4 with both donor and acceptor groups on the benzene ring was obtained (Scheme 5).…”
Section: Resultsmentioning
confidence: 99%
“…The ease of 4-CF 3 -2 H -chromene oxidation at the methylene group has led us to the idea of developing a new approach to the synthesis of practically important 4-CF 3 -coumarins. 20 The oxidation of the methylene group in compounds 2 to the keto group was carried out using CrO 3 in pyridine. 21 As a result, a whole series of 4-CF 3 -coumarins 4 with both donor and acceptor groups on the benzene ring was obtained (Scheme 5).…”
Section: Resultsmentioning
confidence: 99%
“…The main basic structure of chromones serves as a scaffold for novel compounds with biological importance, improving their solubility and pharmacokinetic properties [20][21][22]. In addition, the presence of electron-withdrawing polyfluoroalkyl groups attached to the C-2 carbon of chromones crucially modifies the reactivity and electron-density distribution around the α,β-unsaturated carbonyl portion of the pyrone ring [23]. These changes expand the synthetic potential of 3-substituted-2-polyfluoroalkylchromones, their structural study being our area of interest in this research.…”
Section: Introductionmentioning
confidence: 99%