1985
DOI: 10.1021/jo00223a030
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Fluorination of aromatic derivatives with fluoroxytrifluoromethane and bis(fluoroxy)difluoromethane

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Cited by 32 publications
(11 citation statements)
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“…These fluorinating agents must only be prepared and used by experienced and fully trained personnel. The fluorination agents were prepared by known literature methods: XeF 2 [7], (CF 3 SO 2 ) 2 NF [8], Selectfluor 1 [9], CF 2 (OF) 2 [10], CF 3 OF [10], CH 3 C(O)OF [11], and CF 3 C(O)OF [12].…”
Section: Starting Materialsmentioning
confidence: 99%
“…These fluorinating agents must only be prepared and used by experienced and fully trained personnel. The fluorination agents were prepared by known literature methods: XeF 2 [7], (CF 3 SO 2 ) 2 NF [8], Selectfluor 1 [9], CF 2 (OF) 2 [10], CF 3 OF [10], CH 3 C(O)OF [11], and CF 3 C(O)OF [12].…”
Section: Starting Materialsmentioning
confidence: 99%
“…7 As a result of these drawbacks, many alternative sources of electrophilic uorine were developed. Those are HF, 8 CF 3 OF, 9 BF 3 , 10 CsCoF 4 , 11 XeF 2 (ref. 12) and many more.…”
Section: Introductionmentioning
confidence: 99%
“…The ortho-fluorinated aniline was obtained as a main product in a moderate yield, and the para-fluorinated isomer was also detected (Scheme 2a from F 2 and CO or CO 2 in the presence of CsF, as the fluorinating reagent. 17 Since fluorine gas is highly toxic and difficult to handle, the development of methods for selective direct C−H fluorination of aromatic amines using safe and efficient fluorinating reagents is still highly desirable. In 2017, Liang and Gao developed an amide-assisted radical aromatic C−H fluorination with Selectfluor as an electrophilic fluorination reagent for the preparation of ortho-fluorinated anilides in good yields (Scheme 2b).…”
mentioning
confidence: 99%
“…The ortho -fluorinated aniline was obtained as a main product in a moderate yield, and the para -fluorinated isomer was also detected (Scheme a). A similar strategy was accomplished by Fifolt in 1985 using CF 3 OF or CF 2 (OF) 2 , which were prepared from F 2 and CO or CO 2 in the presence of CsF, as the fluorinating reagent . Since fluorine gas is highly toxic and difficult to handle, the development of methods for selective direct C–H fluorination of aromatic amines using safe and efficient fluorinating reagents is still highly desirable.…”
mentioning
confidence: 99%