Fluorine-19 nuclear magnetic resonance (19F NMR) as a powerful technique for the assay of anti-HIV drug efavirenz in human serum and pharmaceutical formulations

Shamsipur, Mojtaba

doi:10.5897/ajpp11.275

Cited by 7 publications

(2 citation statements)

References 33 publications

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“…We observed that the strength of the fluorine signal in FM C. militaris gradually increased from 0.001 mM to 0.1 mM by comparing the peak value with that of 1,1,1,3,3,3-HFip. The deviation value between FM C. militaris (approximately 118 ppm) and the internal standard CFC-11 (0 ppm) was very close to the deviation value of KF [ 44 ]. Therefore, we assumed that the fluoride detected in FM C. militaris existed as inorganic ions.…”

Section: Resultsmentioning

confidence: 64%

Low Dose of Fluoride in the Culture Medium of Cordyceps militaris Promotes Its Growth and Enhances Bioactives with Antioxidant and Anticancer Properties

Wang

Zhang

et al. 2021

JoF

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Cordyceps militaris possesses several compounds with medicinal properties, and is commonly used in traditional Chinese functional food and medicine for a variety of health benefits. Because of its rare occurrence in nature, the market demand for artificial C. militaris is on the rise. Furthermore, efforts to increase its bioactive ingredients have also been considered in research. In this study, we aimed to investigate the effect of fluoride on the growth and enrichment of bioactive compounds in C. militaris. A wide range of potassium fluoride concentrations (0, 0.001, 0.01, 0.1, and 1 mM) were added to the culture media as a source of fluoride during the cultivation of C. militaris fruiting bodies. The contents of fluorine and bioactive substances of the fruiting bodies in normal (NM) and fluorine-supplemented (FM) media were measured and compared. C. militaris raised in the growth medium supplemented with 0.01 mM potassium fluoride led to a 44.86% (1.55 ± 0.14 g/bottle) increase in biomass and a 23.43% (3161.38 ± 35.71 µg/g) increase in total carotenoid content in the fruiting bodies. Furthermore, a remarkable increase in superoxide dismutase-like activity (84.75 U/mg) and 2,2-diphenyl-1-picrylhydrazyl radical scavenging activity (IC50 = 2.59 mg/mL) was recorded. In human cancer cell-based assays, C. militaris raised in FM caused stronger cytotoxicity, apoptosis, and cell cycle arrest in human osteosarcoma cells. These results demonstrated that a low dose of fluoride could stimulate the growth of C. militaris fruiting bodies and enhance the production of bioactive ingredients that possess useful antioxidant and anticancer activities.

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Section: Resultsmentioning

confidence: 64%

Low Dose of Fluoride in the Culture Medium of Cordyceps militaris Promotes Its Growth and Enhances Bioactives with Antioxidant and Anticancer Properties

Wang

Zhang

et al. 2021

JoF

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“…The complete disappearance of the uoride signal from water (in the NMR detection limit) and the change in the chemical shi values together with the splitting pattern of the precipitate also suggest complexation between Ce and PFOA. 22 It is interesting to see more prominent changes in the chemical shi values in the case of the Ce-PFOA complex than that of the Ce-PFOS complex. In the case of Ce-PFOA complex, initial deprotonation of PFOA is expected prior to complexation/interaction with Ce(IV).…”

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confidence: 98%

Removal of per- and polyfluoroalkyl substances (PFAS) from water by ceric(iv) ammonium nitrate

et al. 2021

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¹⁹ F NMR Spectroscopy: Applications in Pharmaceutical Studies

Lindon

Wilson

2015

eMagRes

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Fluorine-19 nuclear magnetic resonance (19F NMR) as a powerful technique for the assay of anti-HIV drug efavirenz in human serum and pharmaceutical formulations

Cited by 7 publications

References 33 publications

Low Dose of Fluoride in the Culture Medium of Cordyceps militaris Promotes Its Growth and Enhances Bioactives with Antioxidant and Anticancer Properties

Low Dose of Fluoride in the Culture Medium of Cordyceps militaris Promotes Its Growth and Enhances Bioactives with Antioxidant and Anticancer Properties

Removal of per- and polyfluoroalkyl substances (PFAS) from water by ceric(iv) ammonium nitrate

¹⁹ F NMR Spectroscopy: Applications in Pharmaceutical Studies

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Fluorine-19 nuclear magnetic resonance (19F NMR) as a powerful technique for the assay of anti-HIV drug efavirenz in human serum and pharmaceutical formulations

Cited by 7 publications

References 33 publications

Low Dose of Fluoride in the Culture Medium of Cordyceps militaris Promotes Its Growth and Enhances Bioactives with Antioxidant and Anticancer Properties

Low Dose of Fluoride in the Culture Medium of Cordyceps militaris Promotes Its Growth and Enhances Bioactives with Antioxidant and Anticancer Properties

Removal of per- and polyfluoroalkyl substances (PFAS) from water by ceric(iv) ammonium nitrate

19 F NMR Spectroscopy: Applications in Pharmaceutical Studies

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¹⁹ F NMR Spectroscopy: Applications in Pharmaceutical Studies