Fluorocholine PET imaging of parathyroid disease

Prabhu, Meghana; Damle, Nishikant

doi:10.4103/ijem.ijem_707_17

Cited by 21 publications

(29 citation statements)

References 32 publications

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“…17-20 99m Tc-sestamibi scan (complemented with neck ultrasound) is still the most commonly used method in many countries. 18 Sestamibi is a small protein la-belled with the radio-pharmaceutical technetium-99m. The scan is performed by injecting small amount of radioactive material, which is then absorbed by overactive parathyroid gland.…”

Section: Clinical Presentation and Diagnosticsmentioning

confidence: 99%

“…Different studies reported the sensitivity of 99m Tc-sestamibi between 77% and 89%, but up to one-third of patients with adenomas could be sestamibi negative. 18 PET/CT is a newer and promising tool for localization of parathyroid adenomas. Different PET tracers can be used ( 18 F-fluorodeoxyglucose, 18 F-fluorocholine (FCH) etc.).…”

Section: Clinical Presentation and Diagnosticsmentioning

confidence: 99%

“…18 PET/CT is a newer and promising tool for localization of parathyroid adenomas. Different PET tracers can be used ( 18 F-fluorodeoxyglucose, 18 F-fluorocholine (FCH) etc.). 19,21 Many studies are comparing FCH PET/CT with conventional imaging modalities.…”

Section: Clinical Presentation and Diagnosticsmentioning

confidence: 99%

“…Behera and Damle reported the incremental role of PET/CT over sestamibi scan in 2016 because of better spacial resolution, possible detection of smaller adenomas and reduced scanning time. 18,20 Retrospective study by Hočevar et al analysed the results of preoperative localization with FCH PET/CT in 151 patients with PHPT. 21 Choline is a precursor molecule for a major component of the cell membrane and is taken up by hyperfunctioning parathyroid cells and neoplastic cells.…”

Section: Clinical Presentation and Diagnosticsmentioning

confidence: 99%

“…It helps to determine the location and number of hyperfunctioning parathyroid glands and it is very important in the case of recurrent neck procedures. 18 In some western Europe countries conventional imaging with 99m Tc-sestamibi was successfully replaced by neck ultrasound and FCH PET-CT imaging ( Figure 1). 21 In some cases, additional imaging (e.g.…”

Section: Preoperative Management Of Patientsmentioning

confidence: 99%

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Surgical options in treating patients with primary hyperparathyroidism

Majcen

Hočevar

2020

Radiology and Oncology

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BackgroundPrimary hyperparathyroidism is the third most common endocrine disorder for which surgical procedure called parathyroidectomy is the most effective treatment. Since the early 20th century, parathyroid surgery has improved extensively. With the advances in preoperative imaging and with understanding the causes of disease, new and minimally invasive surgical approaches overrode the standard bilateral exploratory operations. Directed parathyroidectomy is currently the standard technique for treatment of primary hyperparathyroidism worldwide.ConclusionsSurgery is the only definitive treatment of primary hyperparathyroidism. The most appropriate type of surgical procedure depends on the number and localization of the hyperactive parathyroid glands, availability of modern imaging techniques, limitation of each type of procedure and expertise.

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Section: Clinical Presentation and Diagnosticsmentioning

confidence: 99%

Section: Clinical Presentation and Diagnosticsmentioning

confidence: 99%

Section: Clinical Presentation and Diagnosticsmentioning

confidence: 99%

Section: Clinical Presentation and Diagnosticsmentioning

confidence: 99%

Section: Preoperative Management Of Patientsmentioning

confidence: 99%

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Surgical options in treating patients with primary hyperparathyroidism

Majcen

Hočevar

2020

Radiology and Oncology

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A rare cause of persistent hyperparathyroidism

Iconaru

Spinato

Duttmann

et al. 2020

Clinical Case Reports

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Impact of Fluoro‐Choline PET/CT in Reduction in Failed Parathyroid Localization in Primary Hyperparathyroidism

Aphale

Damle²,

Chumber³

et al. 2023

World j. surg.

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Introduction Accurate localization of the pathological parathyroid gland is a prerequisite for minimally invasive surgical management of hyperparathyroidism (HPT). Poor imaging or discordance in odd situations like ectopic adenomas, parathyroid hyperplasia, syndromic HPT results in localization dilemma thus causing failed parathyroidectomy. We studied the impact of Fluoro‐Choline (FCH) PET/CT imaging in reduction in localization failure of parathyroid adenoma. Materials and methods We did a retrospective observational study (2018–2021) of HPT among which 97 patients underwent focused parathyroidectomy (FP). All patients had undergone ultrasound imaging and 99mTc‐sestaMIBI scan with early SPECT/CT (MIBI). When this preliminary imaging was doubtful or negative or multiple lesions were expected, FCH PET/CT was performed. We compared the localization accuracy of MIBI scan and FCH PET/CT with surgical outcomes as reference standard. Results MIBI scan showed overall lesion detection rate (LDR) of 88.65% in localization of pathological parathyroid gland in 97 patients. The addition of FCH PET/CT improved the overall lesion detection to 97.9%. The overall possible localization failure was reduced from 11.34 to 2.06% with the addition of FCH PET/CT (p < 0.05). Out of 97 patients of FP, 87 patients showed features of parathyroid adenoma. Single hyperplastic gland was seen in 7 patients, lipoadenoma was seen in 1 patient and 1 patient had features suggestive of parathyroiditis on histopathology. FCH PET/CT was a useful adjunct and showed significant reduction in localization failure of parathyroid adenoma.

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Fluorocholine PET imaging of parathyroid disease

Cited by 21 publications

References 32 publications

Surgical options in treating patients with primary hyperparathyroidism

Surgical options in treating patients with primary hyperparathyroidism

A rare cause of persistent hyperparathyroidism

Impact of Fluoro‐Choline PET/CT in Reduction in Failed Parathyroid Localization in Primary Hyperparathyroidism

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