Fluorometric Determination of Methyldopa in Biological Fluids

Analysis of methyldopa in the presence of phenylephrine using electrocatalytic effect of a ferrocene derivative at a surface of feather like La3+/ZnO nano‐flowers modified carbon paste electrode

“…The methyldopa and phenylephrine can be detected in biological solutions using some existing methods, including spectrofluorimetric, chromatographic and electrochemical techniques. High performance liquid chromatography (HPLC) using electrochemical detector, fluorescence or UV detections are able to measure the drug concentration in urine and plasma samples . However, it may be boring and time consuming the sample preparation in most of these approaches.…”

Liquid phase analysis of methyldopa in the presence of tyrosine using electrocatalytic effect of a catechol derivative at a surface of NiO nanoparticle modified carbon paste electrode

“…Coadministration of methyldopa and alcohol is not recommended due to increasing methyldopa side-effects, such as feeling sleepy or dizzy. Several different analytical methods have been suggested for the analysis of methyldopa that include spectrophotometry [3,4], fluorometry [5], high performance liquid chromatography (HPLC) [6,7], and electrochemical methods [8][9][10]. In between, electrochemical methods can be useful for fast and safe analysis of biological and pharmaceutical samples due to low time analysis and application of water as a usual solvent [11][12][13][14][15][16][17][18][19][20][21][22][23][24].…”

Toward the Understanding of the Metabolism of Levodopa I. DFT Investigation of the Equilibrium Geometries, Acid-Base Properties and Levodopa-Water Complexes

“…Numerous experimental methods have been used to analyze and determine the products of LD metabolism such as radioenzyme [11,12], and chromatographic [13] liquid chromatography (HPLC), UV [14], mass [15,16], electrochemical [17–20] and fluorescence [21–28]. The literature does not seem to contain any theoretical investigation of LD metabolism and as a consequence there is no systematic study of the metabolic reaction pathways, its energetics and transition state.…”