Fluorometric Determination of Salicylic Acid in Buffered Aspirin Products

Spectrofluorometric Determination of Acetylsalicylic Acid, Salicylamide, and Salicylic Acid as an Impurity in Pharmaceutical Preparations

“…The second type utilizes an existing tablet dissolution apparatus that provides a wire mesh basket for holding the sample (16)(17)(18)(19)(20)(21)(22). The third and fourth types employ a membrane; the third consists of a sample chamber separated from a reservoir by a membrane (23-33), whereas the fourth employs dialysis tubing or a natural membrane (33-46).…”

“…Other automated methods use ferric chloride reagent directly (17). Although this method works well for pure acetylsalicylic acid preparations, salicylamide also undergoes the same reaction with ferric reagents used for colorimetric determination (18). The salicylamide content of newer preparations often is as high as 40% of the total salicylate content.…”

Changing student attitudes about quantitative analysis laboratory

“…Current work centers around the determination of salicyclic acid and/or aspirin in alkaline solution (16) but no student results are presently available. This work is being Figure 1.…”

Tableting Research and Technology

“…By measuring the fluorescence intensity of a formic acid-chloroform-treated, powdered, buffered aspirin tablet, Shane and Stillman (457) claimed to have reduced assay time, aside from calibration, to less than 10 min. The authors emphasized that only a monochromatic spectrofluorometer with a solid-state photomultiplier, carefully maintained and periodically calibrated, should be used.…”