Fluorometric method for the determination of lapachol in serum

Finkel, Joe M.; Harrison, S. D.

doi:10.1021/ac60282a035

Cited by 10 publications

(4 citation statements)

References 3 publications

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“…The uptake of quinacrine by tumor tissue was measured by a fluorescence method (292). Blood levels of methotrexate were assayed fluorometrically after permanganate oxidation at pH 5.0 (151); for lapachol, the fluorophore was produced by reduction with sodium bisulfite (291). Daunomycin (NSC-82151) in tissues was also determined by a fluorescence method (47).…”

Section: Organic and Biologicalmentioning

confidence: 99%

Fluorometric analysis

White¹,

Weissler²

1972

Anal. Chem.

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Section: Organic and Biologicalmentioning

confidence: 99%

Fluorometric analysis

White¹,

Weissler²

1972

Anal. Chem.

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“…Reduction with sodium hydrosulfite to a fluorescent product was used for the determination in serum of lapachol, which is 2-hydroxyl-3-(3-methyl-2-butenvl)-l,4-naphthoquinone, an antitumor and antimalarial drug which prevents oxidative synthesis of ATP (196).…”

Section: Steroidsmentioning

confidence: 99%

Fluorometric analysis

White¹,

Weissler²

1970

Anal. Chem.

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“…Fluorometry, which affords the required sensitivity and specificity, has been used in this laboratory for such analytical determinations (1)(2)(3)(4)(5). Very sensitive and specific assays are needed to determine the anticipated low concentrations of anticancer drugs and their metabolites in various biological systems.…”

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confidence: 99%