Fluorophobic Effect Induces the Self-Assembly of Semifluorinated Tapered Monodendrons Containing Crown Ethers into Supramolecular Columnar Dendrimers Which Exhibit a Homeotropic Hexagonal Columnar Liquid Crystalline Phase

Abstract

The rational design, synthesis, and characterization of the building blocks obtained by the esterification of the first generation of tapered monodendrons 3,4,5-tris(p-dodecan-1-yloxy)benzoic acid (12-AG) and 3,4,5-tris[p-(n-dodecan-1-yloxy)benzyloxy]benzoic acid (12-ABG) containing semifluorinated dodecyl groups [i.e., 12Fn-AG-15C5 (n = 0, 4, 6, 8), 12Fn-AG-B15C5, 12Fn-ABG- 15C5, and 12Fn-ABG-B15C5 (n = 0 and 8) where n following the letter F represents the number of outer perfluorinated methylenic units of the dodecyl group] with 4‘-hydroxymethyl(benzo-15-crown-5) (B15C5) and 1-hydroxymethyl(15-crown-5) (15C5) are described. All building blocks self-assemble into supramolecular cylindrical or rod-like dendrimers via ion-mediated complexation processes. These rod-like supermolecules form a thermotropic hexagonal columnar (Φh) liquid crystalline (LC) phase. The fluorination of the dodecyl groups of these tapered building blocks enhances dramatically their self-assembly ability. The building blocks based on n = 6 and 8 self-assemble into supramolecular columns solely via the fluorophobic effect. Direct structural characterization of the supramolecular columns obtained via these two molecular recognition processes by a combination of techniques consisting of differential scanning calorimetry, X-ray diffraction, and thermal optical polarized microscopy, and of the columns obtained solely via the fluorophobic effect allowed the construction of molecular models for the supramolecular columns obtained via these two organizing forces. An increase in the column diameter with increasing n and with the complexation of metal salts (i.e., alkali metal trifluoromethanesulfonates) accounts for a structural model in which the uncomplexed and complexed crown ethers are placed side-by-side in the center of the column with the melted tapered side groups radiating toward its periphery. The perfluorinated segments of the building blocks are microsegregated from the perhydrogenated and aromatic segments of the column. The supramolecular columns obtained from building blocks with n = 8 align homeotropically in the Φh LC phase on untreated glass slides, i.e., form single crystal liquid crystals in which the long axes of their columns are perpendicular to the glass surface. Both the self-assembly of supramolecular columns induced solely by the fluorophobic effect and the homeotropic alignment of these columns in their Φh LC phase open extremely interesting new synthetic and technologic opportunities in the area of self-assembly of well-defined supramolecular architectures obtained from monodendrons and other building blocks.

Partial shell-filled core-shell tecto(dendrimers): A strategy to surface differentiated nano-clefts and cusps

“…The close scaling of size (30,33), shape, and quasi-equivalency of surfaces (37)(38)(39) observed between nanoscale biostructures and various dendrimer families͞generational levels is both striking and provocative (30,40). These remarkable similarities suggest a broad strategy based on rational biomimicry as a means for creating a repertoire of structure-controlled, sizevariable, and shape-variable dendrimer assemblies.…”

Dynamic hybrid materials for constitutional self-instructed membranes

“…It has already been shown that cations can template the formation of ion-channel columnar architectures. Seminal work by Percec et al (15)(16)(17)(18)(19)(20) has demonstrated the self-assembly of dendronized crown ethers into ion channels via complexation of cations. The G-quartet, the hydrogen-bonded macrocycle formed by the self-assembly of four guanosines, is stabilized by cations.…”

A Review on Dendrimers and Metallodendrimers, the Important Compounds as Catalyst in Material Chemistry

“…Each repeating units bears a branching point to which two or several new repeating units are attached. Owing to their unique properties such as solubility in water, well defined molecular architecture, and spherical shape, dendrimers and metallodendrimers have found numerous applications in chemical, physical and biological processes [16][17][18].…”