2021
DOI: 10.1002/mabi.202100024
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Fluoropolymer‐Mediated Intracellular Delivery of miR‐23b for the Osteocyte Differentiation in Osteoblasts

Abstract: Emerging evidence suggests that microRNAs (miRNAs) play key roles in the regulation of multiple biological processes, including the differentiation of osteoblasts. Although miRNA‐based gene therapy holds immense potential in the treatment of a variety of diseases, the intracellular delivery of miRNA remains challenging owing to the lack of efficient and safe gene carriers. In this study, a fluoropolymer (FP) is constructed through the modification of polyamidoamine (PAMAM) using heptafluorobutyric anhydride an… Show more

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Cited by 3 publications
(3 citation statements)
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“…66 Fluoropolymer vectors and guanidinobenzoic acid-based polymers demonstrated successful cytosolic delivery by shielding the positive surface charge and destabilizing the endosomal membrane. 67 Thus, nanocarriers hold promise for facilitating endosomal escape by membrane destabilization.…”
Section: Endosomal Escape Strategies For An Antibiotic Redistributionmentioning
confidence: 99%
“…66 Fluoropolymer vectors and guanidinobenzoic acid-based polymers demonstrated successful cytosolic delivery by shielding the positive surface charge and destabilizing the endosomal membrane. 67 Thus, nanocarriers hold promise for facilitating endosomal escape by membrane destabilization.…”
Section: Endosomal Escape Strategies For An Antibiotic Redistributionmentioning
confidence: 99%
“…[5][6][7] Fluoropolymers include polytetrafluoroethylene, polytrifluoroethylene, polyvinylidene fluoride, polyvinyl fluoride, fluorinated epoxy resin, and so on. [8][9][10][11][12][13] Among them, fluorinated epoxy resin has electrical insulation and low shrinkage, but their high temperature resistance is not suitable for certain applications in special environments. [14][15][16][17][18][19][20] The dielectric properties of fluorinated epoxy resins have also been studied, suggesting that it can be used in related industries such as electronic devices.…”
Section: Introductionmentioning
confidence: 99%
“…These properties make fluoropolymers the material of choice for products such as heat‐resistant cables, chemical‐resistant linings, electronic components, cladding materials, and weather‐resistant films 5–7 . Fluoropolymers include polytetrafluoroethylene, polytrifluoroethylene, polyvinylidene fluoride, polyvinyl fluoride, fluorinated epoxy resin, and so on 8–13 . Among them, fluorinated epoxy resin has electrical insulation and low shrinkage, but their high temperature resistance is not suitable for certain applications in special environments 14–20 .…”
Section: Introductionmentioning
confidence: 99%