Fluoroquinolone consumption and Escherichia coli resistance in Japan: an ecological study

Terahara, Fumitaka; Nishiura, Hiroshi

doi:10.1186/s12889-019-6804-3

Cited by 31 publications

(27 citation statements)

References 28 publications

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“…However, it must be noted that a high volume of fluoroquinolone prescribing for other conditions ( 52 ) is likely to have a greater impact on fluoroquinolone resistance both in the individual and the community. Indeed, it has been shown that high fluoroquinolone use in general has been associated with an increased prevalence of resistance in E. coli over time in Eastern Asia ( 53 – 56 ).…”

Section: Discussionmentioning

confidence: 99%

Escherichia coli Resistance to Fluoroquinolones in Community-Acquired Uncomplicated Urinary Tract Infection in Women: a Systematic Review

Stapleton

Wagenlehner

Mulgirigama³

et al. 2020

Antimicrob Agents Chemother

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Antibiotic resistance represents a threat to public health, and uncomplicated urinary tract infections (uUTIs) are an example of this concern. This systematic review (PROSPERO ID: CRD42020156674) is the first to determine the prevalence of E. coli resistance to fluoroquinolones in women with community-acquired uUTI. PubMed and Embase searches were conducted, 38 studies fulfilled eligibility criteria and were included in the systematic review. Within Europe, ciprofloxacin resistance in E. coli isolates varied between countries, and increased in some between 2006–8 and 2014–16, specifically in the UK (0.5% to 15.3%), Germany (8.7% to 15.1%), and Spain (22.9% to 30.8%), although methodologies and settings were often not comparable. In Asia there was a substantial increase in ciprofloxacin resistance during 2008–14 from 25% to more than 40%. In North America, resistance to ciprofloxacin also increased between 2008–2017, from 4% to 12%. Data exploring different age groups did not show a consistent relationship with resistance, whereas two studies found that fluoroquinolone resistance was higher in postmenopausal women than premenopausal women. One study indicated a link between fluoroquinolone resistance and uUTI recurrence. These findings may have implications for empirical treatment of uUTI with fluoroquinolones globally, but more data are needed to fully understand regional situations and impact on patient management.

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Section: Discussionmentioning

confidence: 99%

Escherichia coli Resistance to Fluoroquinolones in Community-Acquired Uncomplicated Urinary Tract Infection in Women: a Systematic Review

Stapleton

Wagenlehner

Mulgirigama³

et al. 2020

Antimicrob Agents Chemother

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“…Use of quinolones confers a selection pressure that results in enrichment of a resistant subpopulation of bacteria. In line with this, use of quinolones has been linked to increased occurrence of resistant bacteria in both human and veterinary sectors (Teuber, 2001;Terahara and Nishiura, 2019). The presence of quinolone resistant E. coli (QREC) in the broiler production chain may have a public health implication, but data on these aspects are limited and the implications are therefore unclear.…”

Section: Introductionmentioning

confidence: 99%

Comparative Genome Analyses of Wild Type- and Quinolone Resistant Escherichia coli Indicate Dissemination of QREC in the Norwegian Broiler Breeding Pyramid

et al. 2020

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Quinolones are important antimicrobials for both humans and animals, and resistance toward these compounds is a serious threat to public health. In Norway, quinolone resistant E. coli (QREC) have been detected at low levels in a high proportion of broiler flocks, even without the use of quinolones in rearing of broilers. Due to the pyramidal structure of broiler breeding, QREC isolates may be disseminated from grandparent animals down through the pyramid. However, quinolone resistance can also develop in wild type E. coli through specific chromosomal mutations, and by horizontal acquisition of plasmid-mediated quinolone resistance genes. The goal of this study was to determine whether QREC is disseminated through the broiler breeding pyramid or developed locally at some stage in the broiler production chain. For this purpose, we whole genome sequenced wild type-and QREC isolates from broiler and parent flocks that had been isolated in the Norwegian monitoring program for antimicrobial resistance in feed, food and animals (NORM-VET) between 2006 and 2017, from 22 different production sites. The sequencing data was used for typing of the isolates, phylogenetic analysis and identification of relevant resistance mechanisms. Highly similar QREC isolates were identified within major sequence types from multiple production sites, suggesting dissemination of QREC isolates in the broiler production chain. The occurrence of potential resistance development among the WT E. coli was low, indicating that this may be a rare phenomenon in the Norwegian broiler production. The results indicate that the majority of the observed QREC at the bottom of the broiler production pyramid originates from parent or grandparent animals. These results highlight the importance of surveillance at all levels of the broiler production pyramid and of implementation of proper biosecurity measures to control dissemination of QREC.

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“…Fifth, infection risk depends on both (i) human behaviors that lead to tick bites and (ii) the risk of infection among ticks (and animals) [47–49]. In the present study, we could not distinguish (i) and (ii) nor elucidate the detailed ecological mechanisms behind the observations [50]; this would require cross-disciplinary collaboration among epidemiologists and statisticians as well as entomologists, ecologists, veterinarians, and virologists.…”

Section: Discussionmentioning

confidence: 95%

Spatial epidemiological determinants of severe fever with thrombocytopenia syndrome in Miyazaki, Japan: a GWLR modeling study

Yasuo

Nishiura

2019

BMC Infect Dis

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Background Cases of severe fever with thrombocytopenia syndrome (SFTS) have increasingly been observed in Miyazaki, southwest Japan. It is critical to identify and elucidate the risk factors of infection at community level. In the present study, we aimed to identify areas with a high risk of SFTS virus infection using a geospatial dataset of SFTS cases in Miyazaki. Methods Using 10 × 10-km mesh data and a geographically weighted logistic regression (GWLR) model, we examined the statistical associations between environmental variables and spatial variation in the risk of SFTS. We collected geospatial and population census data as well as forest and agriculture mesh information. Altitude and farmland were selected as two specific variables for predicting the presence of SFTS cases in a given mesh area. Results Using GWLR, the area under the receiver operating characteristic curve (AUC) was estimated at 73.9%, outperforming the classical logistic regression model (72.4%). The sensitivity and specificity of the GWLR model were estimated at 90.9 and 58.7%, respectively. We identified altitude (odds ratio (OR) = 0.996, 95% confidence interval (CI): 0.994–0.999 per one-meter elevation) and farmland (OR = 0.999, 95% CI: 0.998–1.000 per % increase) as useful negative predictors of SFTS cases in Miyazaki. Conclusions Our study findings revealed that the risk of SFTS is high in geographic areas where farmland area begins to diminish and at mid-level altitudes. Our findings can help to improve the efficiency of ecological and animal surveillance in high-risk areas. Using finer geographic resolution, such surveillance can help raise awareness among local residents in areas with a high risk of SFTS. Electronic supplementary material The online version of this article (10.1186/s12879-019-4111-3) contains supplementary material, which is available to authorized users.

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Fluoroquinolone consumption and Escherichia coli resistance in Japan: an ecological study

Cited by 31 publications

References 28 publications

Escherichia coli Resistance to Fluoroquinolones in Community-Acquired Uncomplicated Urinary Tract Infection in Women: a Systematic Review

Escherichia coli Resistance to Fluoroquinolones in Community-Acquired Uncomplicated Urinary Tract Infection in Women: a Systematic Review

Comparative Genome Analyses of Wild Type- and Quinolone Resistant Escherichia coli Indicate Dissemination of QREC in the Norwegian Broiler Breeding Pyramid

Spatial epidemiological determinants of severe fever with thrombocytopenia syndrome in Miyazaki, Japan: a GWLR modeling study

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