Fluoroquinolone pollution of food, water and soil, and bacterial resistance

Rusu, Aura; Hancu, Gabriel; Uivaroşi, Valentina

doi:10.1007/s10311-014-0481-3

Cited by 84 publications

(45 citation statements)

References 61 publications

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“…At the same time for the quantification of the analyte from marketed formulations and in bulk a proper sample preparation procedure is often required when the excepients in formulations (suspensions, lotions, creams) interferes with the analyte 36 . In such cases sample pretreatment is often necessary [27][28][29][30][31][32][33][34][35][36] . Thus possible chromatographic interferences and clogging or detoriation of the column can be avoided.…”

Section: Methodology: 21 Sample Preparationmentioning

confidence: 99%

“…A number of chromatographic techniques have been developed in last two decades for the quantification of newer fluoroquinolones 14-22 from a variety of sample matrices. The introduction of chromatographic techniques has revolutionized the process of detection, separation and quantification of the parent components and the respective metabolites with higher selectivity, sensitivity, precession and accuracy form a variety of sample matrices including biological and environmental matrices [22][23][24][25][26][27][28][29][30][31][32][33][34][35] . Moreover these chromatographic techniques can be derived from available techniques with slight modification or can be developed on the basis of knowledge gathered through experience and physical properties of the analyte under consideration.…”

Section: Available Analytical Techniques For the Quantification Of Qumentioning

confidence: 99%

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Untitled

2016

IJPSR

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ABSTRACT:Fluoroquinolones are the most commonly prescribed synthetic antibacterial agents having improved pharmacokinetic properties and broad spectrum of activity. Due to their broad clinical activity they are the most promising drug for antibacterial chemotherapy. The current study focused on the application of similar chromatographic system for the analysis of a number of fluoroquinolones from bulk, pharmaceutical formulations and biological matrices. We have also summarized how a single chromatographic system can be used for the quantification of a number of fluoroquinoloes from their respective marketed formulation. A detailed systemic survey of the sample preparation techniques, the chromatographic conditions and detection of the respective fluoroquinolones has been presented in this study. In the course of this discussion the advantages and applicability of the high performance liquid chromatographic techniques are also examined.

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Section: Methodology: 21 Sample Preparationmentioning

confidence: 99%

Section: Available Analytical Techniques For the Quantification Of Qumentioning

confidence: 99%

Untitled

2016

IJPSR

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“…This indicates that the unaltered form of this drug can reach surface waters (5,6). LOM is the fourth-most-prescribed FQ in the worldwide (7). It is a second generation FQ.…”

Section: Introductionmentioning

confidence: 99%

Lomefloxacin Degradation: Antimicrobial Activity, Toxicity and Byproducts

Oliveira¹,

Maniero²,

Guimarães³

2015

Journal of Advanced Oxidation Technologies

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Abstract:Lomefloxacin (LOM) is an important antimicrobial drug. It has been detected in aqueous matrices in several countries. Its continuous introduction into the environment is a potential risk to aquatic and terrestrial organisms. The aim of this study was to evaluate the degradation of LOM by photolysis, peroxidation, and peroxidation assisted by ultraviolet radiation; moreover, the residual antimicrobial activity, the toxicity, and the byproducts formed during degradation processes were evaluated. Peroxidation was inefficient for LOM degradation and was not able to reduce antimicrobial activity. Both photolysis and UV/H 2 O 2 were able to degrade more than 95% of LOM in 60 min (radiation dose of 5267 mJ cm -2 ). However, toxicity increased while these processes were being applied. For all processes evaluated, antimicrobial activity was still detected in the solution after 60 min of testing. Four byproducts were identified: m/z 332, 336, 348, and 350.

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“…Thereby, organometallic complexes can be a valuable alternative in the fight against bacterial resistance. 10 , 11 The study of organometallic complexes also includes the development of efficient methods for their analysis. The current paper presents a review of several analytical methods applied in the analysis of silver complexes with antibacterial quinolones.…”

Section: Introductionmentioning

confidence: 99%

Essential Guide of Analysis Methods Applied to Silver Complexes with Antibacterial Quinolones

Rusu¹,

Hancu²,

Imre³

2018

Adv Pharm Bull

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To describe the chemical structure and characterize physico-chemical properties of organometallic complexes it is necessary to use a complex set of analysis methods. Thus, this review has been compiled as a relevant guide which includes the most commonly used methods of analysis in the study of silver complexes with antibacterial quinolones, compounds with promising biological potential. This selection of analysis methods puts on balance the obtained data and the accessibility of the experimental approach. The steps to follow in order to obtain reliable structural information about organometallic complexes of silver, particularly the silver complexes of antibacterial quinolones, are established and presented in the review.

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Fluoroquinolone pollution of food, water and soil, and bacterial resistance

Cited by 84 publications

References 61 publications

Untitled

Untitled

Lomefloxacin Degradation: Antimicrobial Activity, Toxicity and Byproducts

Essential Guide of Analysis Methods Applied to Silver Complexes with Antibacterial Quinolones

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