Cochrane Database of Systematic Reviews 2005
DOI: 10.1002/14651858.cd004530.pub2
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Fluoroquinolones for treating typhoid and paratyphoid fever (enteric fever)

Abstract: Many trials were small, and methodological quality varied widely. Although enteric fever most commonly affects children, trials in this group were particularly sparse. Insufficient data in all comparisons preclude any firm conclusions to be made regarding superiority of fluoroquinolones over first-line antibiotics in children and adults.

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Cited by 17 publications
(4 citation statements)
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“…Typically trials in typhoid fever are limited by small sample sizes, a recent Cochrane Report has stressed the need for large well-designed trials in enteric fever [29]. The evidence from our trial is strengthened by a sample size of 287 patients with culture confirmed typhoid fever (358 patients randomised), which we believe is so far the largest RCT performed in typhoid fever.…”
Section: Discussionmentioning
confidence: 69%
See 1 more Smart Citation
“…Typically trials in typhoid fever are limited by small sample sizes, a recent Cochrane Report has stressed the need for large well-designed trials in enteric fever [29]. The evidence from our trial is strengthened by a sample size of 287 patients with culture confirmed typhoid fever (358 patients randomised), which we believe is so far the largest RCT performed in typhoid fever.…”
Section: Discussionmentioning
confidence: 69%
“…We performed a MEDLINE search for “azithromycin, clinical trial, typhoid/enteric fever” and used the recent enteric fever Cochrane report [29] to identify 6 clinical trials in the literature. In total, 251 typhoid fever patients were treated with azithromycin.…”
Section: Discussionmentioning
confidence: 99%
“…Although enteric fever is essentially a paediatric disease in South Asia, there is dearth of retrospective and prospective studies done in children with culture proven enteric fever in the global literature [ 22 ]. Furthermore, most studies on enteric fever represent hospitalized subjects and the differences in the clinical features and severity of the disease may also differ substantially from those not requiring hospitalization.…”
mentioning
confidence: 99%
“…Drug resistance in typhoid fever is considered one of the most important factors in determining the morbidity and mortality of the disease. The quinolone group of drugs emerged as the alternative useful drugs for the treatment of multiple drug resistant cases of Salmonella Typhi but unfortunately, ciprofloxacin resistance in the Salmonella Paratyphi A isolates has been reported from various parts of India [16][17][18]. Adverse impact of Nalidixic acid resistant Salmonella Typhi (NARST) strains, with longer duration of fever, higher frequency of hepatomegaly and elevated liver enzymes with increased Minimum Inhibitory Concentration (MIC) of ciprofloxacin have been reported [19].…”
Section: Discussionmentioning
confidence: 99%