Fluorouracil and Leucovorin in Advanced Breast Cancer

Doroshow, James H.; Margolin, Kim; Leong, Lucille; Akman, Steven A.; Morgan, Robert J.; Raschko, James; Hamasaki, Victor; Womack, Eleanor; Newman, Edward M.; Ahn, Chul

doi:10.1007/978-1-4615-2488-5_19

Cited by 1 publication

(1 citation statement)

References 15 publications

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“…[6][7][8][9][10][11][12] Chemotherapy, especially fluorouracil (5-FU), is used as a supplementary treatment for breast cancer and has significantly improved the prognosis of breast cancer patients. [13][14][15][16][17][18] However, the chemotherapy with 5-FU is not always effective, in which some breast cancer cells may survive the 5-FU treatment through enhanced autophagy. Hence, there is a need for suppressing breast cancer cell autophagy during 5-FU treatment.…”

Section: Introductionmentioning

confidence: 99%

Crocetin shifts autophagic cell survival to death of breast cancer cells in chemotherapy

Zhang

2017

Tumour Biol.

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The chemotherapy with fluorouracil is not always effective, in which some breast cancer cells may survive the fluorouracil treatment through enhanced autophagy. Crocetin is the major constituent of saffron, a Chinese traditional herb, which has recently found to have multiple pharmacological effects, including anticancer. However, the effects of Crocetin on the outcome of fluorouracil therapy for breast cancer have not been studied. Here, we showed that fluorouracil treatment inhibited the growth of breast cancer cells, in either a Cell Counting Kit-8 assay or an MTT assay. Inhibition of autophagy further suppressed breast cancer cell growth, suggesting that the breast cancer cells increased autophagic cell survival during fluorouracil treatment. However, Crocetin significantly increased the suppressive effects of fluorouracil on breast cancer cell growth, without affecting either cell apoptosis or autophagy. Inhibition of autophagy at the presence of Crocetin partially abolished the suppressive effects on breast cancer cell growth, suggesting that Crocetin may increase autophagic cell death in fluorouracil-treated breast cancer cells. Furthermore, Crocetin decreased Beclin-1 levels but increased ATG1 levels in fluorouracil-treated breast cancer cells. Together, these data suggest that Crocetin may shift autophagic cell survival to autophagic cell death in fluorouracil-treated breast cancer cells, possibly through modulation of the expression of ATG1 and Beclin-1.

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Section: Introductionmentioning

confidence: 99%

Crocetin shifts autophagic cell survival to death of breast cancer cells in chemotherapy

Zhang

2017

Tumour Biol.

View full text Add to dashboard Cite

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Fluorouracil and Leucovorin in Advanced Breast Cancer

Cited by 1 publication

References 15 publications

Crocetin shifts autophagic cell survival to death of breast cancer cells in chemotherapy

Crocetin shifts autophagic cell survival to death of breast cancer cells in chemotherapy

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