Fluorous Linker-Facilitated Chemical Synthesis

Cyclohexane-Based Liquid-Biphasic Systems for Organic Electrochemistry

“…In contrast, the reaction yields were significantly improved when the cyclohexane-based liquid-biphasic system was used. After the electrochemical reaction, the biphasic condition was reformed through cooling to enable the facile separation of the coupled products (7)(8)(9)(10). These results show the possibility of using cyclohexane-based liquid-biphasic systems in organic electrochemistry.…”

“…In addition to the solid-phase technique, the liquid-biphasic technique can also provide a facile separation of compounds by simple liquid-liquid extraction. A representative liquidbiphasic technique is based on the insolubility of perfluorinated hydrocarbons with both polar and less-polar organic solvents, known as fluorous systems [7][8][9][10][11]. In these systems, fluorous compounds, including substrates, products, and catalysts, or designed fluorous platforms, are preferentially dissolved into the fluorous phase to enable their rapid separation.…”

Development of Analytical Methods Utilizing Selectivity of Fluorous Affinity and Their Applications

“…Furthermore, they have a remarkable affinity for one another, which is termed "fluorophilicity", in spite of their lipophobicity and hydrophobicity. Utilizing their fluorous affinities, perfluoroalkyl-containing (fluorous) compounds can be easily distinguished from non-fluorous compounds by using their solvent (e.g., perfluoroalkanes) or material (e.g., perfluoroalkyl-modified silica gel) analogues [1][2][3][4]. Although fluorous separation techniques, such as fluorous biphasic liquid-liquid extraction (F-LLE) and fluorous solid phase extraction (F-SPE), have been conventionally used for enrichment and/or purification in organic biomolecule synthesis, their application to biogenic-related compound analyses has been recently reported [5,6].…”

A Fluorous Biphasic Solvent Extraction System for Lanthanides with a Fluorophilic β-Diketone Type Extractant

“…mostly perfluorinated alkanes, ethers and tertiary amines) have attracted much interest in a wide range of fields in organic chemistry, biochemistry, and material science. [23][24][25][26] The water solubility in fluorous solvents is remarkably low. Fluorous solvents are nontoxic, non-flammable, chemically stable, and immiscible with water.…”