Fluoxetine alters behavioral consistency of aggression and courtship in male Siamese fighting fish, Betta splendens

Dzieweczynski, Teresa L.; Hebert, Olivia L.

doi:10.1016/j.physbeh.2012.06.007

Cited by 95 publications

(54 citation statements)

References 44 publications

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“…Perhaps fluoxetine, through modulation of serotonin levels, stimulates crab activity levels and drives aggressive behaviors. Fluoxetine's effect on serotonin levels appears to increase boldness and potentially other risk behaviors as studies on other species have suggested (Dzieweczynski & Hebert, 2012; Fong & Ford, 2014; Mesquita et al., 2011; Pedetta et al., 2010; Tierney & Mangiamele, 2001). …”

Section: Discussionmentioning

confidence: 88%

“…In the same crab species, 120 μg/L of fluoxetine significantly altered locomotor behaviors (Mesquita, Guilhermino, & Guimaraes, 2011). Several other studies have demonstrated that fluoxetine leads to adverse physiological and behavioral outcomes in aquatic organisms that could alter their functional roles within the community (Bossus, Guler, Short, Morrison, & Ford, 2014; Chen, Zha, Yuan, & Wang, 2015; Dzieweczynski & Hebert, 2012; Munari, Marin, & Matozzo, 2014; Peters & Granek, 2016; Schultz et al., 2011). …”

Section: Introductionmentioning

confidence: 99%

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Prozac in the water: Chronic fluoxetine exposure and predation risk interact to shape behaviors in an estuarine crab

Peters

Granek

Rivera

et al. 2017

Ecology and Evolution

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Predators exert considerable top‐down pressure on ecosystems by directly consuming prey or indirectly influencing their foraging behaviors and habitat use. Prey is, therefore, forced to balance predation risk with resource reward. A growing list of anthropogenic stressors such as rising temperatures and ocean acidification has been shown to influence prey risk behaviors and subsequently alter important ecosystem processes. Yet, limited attention has been paid to the effects of chronic pharmaceutical exposure on risk behavior or as an ecological stressor, despite widespread detection and persistence of these contaminants in aquatic environments. In the laboratory, we simulated estuarine conditions of the shore crab, Hemigrapsus oregonensis, and investigated whether chronic exposure (60 days) to field‐detected concentrations (0, 3, and 30 ng/L) of the antidepressant fluoxetine affected diurnal and nocturnal risk behaviors in the presence of a predator, Cancer productus. We found that exposure to fluoxetine influenced both diurnal and nocturnal prey risk behaviors by increasing foraging and locomotor activity in the presence of predators, particularly during the day when these crabs normally stay hidden. Crabs exposed to fluoxetine were also more aggressive, with a higher frequency of agonistic interactions and increased mortality due to conflicts with conspecifics. These results suggest that exposure to field‐detected concentrations of fluoxetine may alter the trade‐off between resource acquisition and predation risk among crabs in estuaries. This fills an important data gap, highlighting how intra‐ and interspecific behaviors are altered by exposure to field concentrations of pharmaceuticals; such data more explicitly identify potential ecological impacts of emerging contaminants on aquatic ecosystems and can aid water quality management.

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Section: Discussionmentioning

confidence: 88%

Section: Introductionmentioning

confidence: 99%

Prozac in the water: Chronic fluoxetine exposure and predation risk interact to shape behaviors in an estuarine crab

Peters

Granek

Rivera

et al. 2017

Ecology and Evolution

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“…Further, some pharmaceuticals have the potential to alter sociality [33], and thereby schooling tendency. However, despite the potential impact of pharmaceuticals on wildlife behaviour, and the demonstrated importance of animal behaviour for fitness, population dynamics and ecosystem functioning, few studies have investigated the ecological implications of pharmaceutically induced behavioural modifications (but see [32,33,45]). It is a fact that certain behaviours directly affect fitness, and it is therefore probable that pharmaceuticals designed to alter behaviour will influence the fitness of exposed individuals.…”

Section: (C) Potential Ecological Effects Of Pharmaceuticals Via Behamentioning

confidence: 99%

Ecological effects of pharmaceuticals in aquatic systems—impacts through behavioural alterations

Brodin

Piovano

Fick

et al. 2014

Phil. Trans. R. Soc. B

409

257

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The study of animal behaviour is important for both ecology and ecotoxicology, yet research in these two fields is currently developing independently. Here, we synthesize the available knowledge on drug-induced behavioural alterations in fish, discuss potential ecological consequences and report results from an experiment in which we quantify both uptake and behavioural impact of a psychiatric drug on a predatory fish ( Perca fluviatilis ) and its invertebrate prey ( Coenagrion hastulatum ). We show that perch became more active while damselfly behaviour was unaffected, illustrating that behavioural effects of pharmaceuticals can differ between species. Furthermore, we demonstrate that prey consumption can be an important exposure route as on average 46% of the pharmaceutical in ingested prey accumulated in the predator. This suggests that investigations of exposure through bioconcentration, where trophic interactions and subsequent bioaccumulation of exposed individuals are ignored, underestimate exposure. Wildlife may therefore be exposed to higher levels of behaviourally altering pharmaceuticals than predictions based on commonly used exposure assays and pharmaceutical concentrations found in environmental monitoring programmes.

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“…Siamese fighting fish of the veil-tail strain are an ideal subject for ecotoxicology studies using behavioral endpoints because they have well-defined behaviors (Simpson, 1968), consistent individual variation in multiple behaviors including boldness (e.g. Dzieweczynski and Hebert, 2012;Hebert et al, 2014), and few studies have examined the effects of PPCPs on fish from tropical regions (Brooks, 2014). Fluoxetine injected intramuscularly did not alter aggression levels in male Siamese fighting fish in one study (Clotfelter et al, 2007), but decreased aggression in another study (Kania et al, 2012), perhaps because of differences in the type of aggressive stimulus used and duration of exposure.…”

Section: Introductionmentioning

confidence: 99%

“…Fluoxetine injected intramuscularly did not alter aggression levels in male Siamese fighting fish in one study (Clotfelter et al, 2007), but decreased aggression in another study (Kania et al, 2012), perhaps because of differences in the type of aggressive stimulus used and duration of exposure. Male Siamese fighting fish have been shown to be less aggressive (Dzieweczynski and Hebert, 2012), even after as little as 3 h of exposure to 3 µg ml −1 of fluoxetine-treated water (Lynn et al, 2007), and less active (Kohlert et al, 2012) after exposure to fluoxetine via water. Given that it has recently been found that female Siamese fighting fish are less active and explore less after fluoxetine exposure (Dzieweczynski et al, 2016), we hypothesized that similar reductions in behavior would be seen in males.…”

Section: Introductionmentioning

confidence: 99%

Dose-dependent fluoxetine effects on boldness in male Siamese fighting fish

Dzieweczynski

Campbell

Kane

2016

Journal of Experimental Biology

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As the use of pharmaceuticals and personal care products (PPCPs) continues to rise, these compounds enter the environment in increasing frequency. One such PPCP, fluoxetine, has been found in detectable amounts in aquatic ecosystems worldwide, where it may interfere with the behavior of exposed organisms. Fluoxetine exposure has been found to influence boldness and exploration in a range of fish species; however, how it might alter behavior in multiple contexts or over time is rarely examined. To this end, the effects of fluoxetine on boldness over time were studied in male Siamese fighting fish. Three different groups of males (0, 0.5 and 5 µg l −1 fluoxetine) were tested in multiple boldness assays (empty tank, novel environment and shoal) once a week for 3 weeks to collect baseline measures and then at three different time points postexposure. The effects of these varying exposure amounts on behavior were then examined for overall response, consistency and across-context correlations. Unexposed males were bolder in all contexts, were more consistent within a context, and had stronger between-context correlations than exposed males. Fluoxetine had dose-dependent effects on behavior, as males that received the higher dose exhibited greater behavioral effects. This study stresses the potential fitness consequences of fluoxetine exposure and suggests that examining behavioral effects of PPCPs under different dosing regimens and in multiple contexts is important to gain an increased understanding of how exposure affects behavior.

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Fluoxetine alters behavioral consistency of aggression and courtship in male Siamese fighting fish, Betta splendens

Cited by 95 publications

References 44 publications

Prozac in the water: Chronic fluoxetine exposure and predation risk interact to shape behaviors in an estuarine crab

Prozac in the water: Chronic fluoxetine exposure and predation risk interact to shape behaviors in an estuarine crab

Ecological effects of pharmaceuticals in aquatic systems—impacts through behavioural alterations

Dose-dependent fluoxetine effects on boldness in male Siamese fighting fish

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